SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3p01'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3p01 TWO-COMPONENT
RESPONSE REGULATOR
(Nostoc
sp.
PCC
7120) 		3 / 3 VAL A 304
ALA A 301
HIS A 298
 None
 0.77A 1q23C-3p01A:
undetectable		 1q23C-3p01A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3p01 TWO-COMPONENT
RESPONSE REGULATOR
(Nostoc
sp.
PCC
7120) 		3 / 3 VAL A 304
ALA A 301
HIS A 298
 None
 0.77A 1q23L-3p01A:
undetectable		 1q23L-3p01A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3p01 TWO-COMPONENT
RESPONSE REGULATOR
(Nostoc
sp.
PCC
7120) 		4 / 7 ARG A 290
ALA A 158
ARG A 154
ASP A 292
 None
 1.12A 2e5dA-3p01A:
undetectable
2e5dB-3p01A:
undetectable		 2e5dA-3p01A:
16.83
2e5dB-3p01A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3p01 TWO-COMPONENT
RESPONSE REGULATOR
(Nostoc
sp.
PCC
7120) 		4 / 7 ASP A 292
ARG A 290
ALA A 158
ARG A 154
 None
 1.07A 2e5dA-3p01A:
undetectable
2e5dB-3p01A:
undetectable		 2e5dA-3p01A:
16.83
2e5dB-3p01A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 3p01 TWO-COMPONENT
RESPONSE REGULATOR
(Nostoc
sp.
PCC
7120) 		3 / 3 GLN A 210
THR A 229
TRP A 222
 None
 0.96A 2rctA-3p01A:
undetectable		 2rctA-3p01A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 3p01 TWO-COMPONENT
RESPONSE REGULATOR
(Nostoc
sp.
PCC
7120) 		3 / 3 GLU A 293
PHE A 191
GLN A 159
 None
 0.91A 3r55A-3p01A:
0.8		 3r55A-3p01A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 3p01 TWO-COMPONENT
RESPONSE REGULATOR
(Nostoc
sp.
PCC
7120) 		5 / 12 LEU A 279
LEU A 308
ILE A 209
LEU A 176
LEU A 206
 None
 1.22A 4j24D-3p01A:
undetectable		 4j24D-3p01A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3p01 TWO-COMPONENT
RESPONSE REGULATOR
(Nostoc
sp.
PCC
7120) 		6 / 12 ILE A 183
LEU A 281
LEU A 198
ALA A 301
SER A 300
LEU A 166
 None
 1.21A 4m11B-3p01A:
undetectable		 4m11B-3p01A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 3p01 TWO-COMPONENT
RESPONSE REGULATOR
(Nostoc
sp.
PCC
7120) 		4 / 7 LEU A 289
LEU A 228
LEU A 281
ILE A 244
 None
 1.04A 4okwA-3p01A:
undetectable		 4okwA-3p01A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 3p01 TWO-COMPONENT
RESPONSE REGULATOR
(Nostoc
sp.
PCC
7120) 		5 / 12 LEU A 279
LEU A 308
ILE A 209
LEU A 176
LEU A 206
 None
 1.26A 5toaB-3p01A:
undetectable		 5toaB-3p01A:
22.75