SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3p0u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3p0u NUCLEAR RECEPTOR
SUBFAMILY 2 GROUP C
MEMBER 2
(Homo
sapiens) 		5 / 12 ILE A 506
LEU A 559
ILE A 517
LEU A 566
PRO A 567
 None
 1.04A 1rx8A-3p0uA:
undetectable		 1rx8A-3p0uA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 3p0u NUCLEAR RECEPTOR
SUBFAMILY 2 GROUP C
MEMBER 2
(Homo
sapiens) 		5 / 10 TYR A 513
ILE A 517
ALA A 516
ILE A 506
ILE A 562
 None
 1.27A 2dm6A-3p0uA:
undetectable
2dm6B-3p0uA:
undetectable		 2dm6A-3p0uA:
23.41
2dm6B-3p0uA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 3p0u NUCLEAR RECEPTOR
SUBFAMILY 2 GROUP C
MEMBER 2
(Homo
sapiens) 		4 / 7 LEU A 494
GLU A 444
LEU A 445
MET A 457
 None
 1.22A 2w8yA-3p0uA:
14.1		 2w8yA-3p0uA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3p0u NUCLEAR RECEPTOR
SUBFAMILY 2 GROUP C
MEMBER 2
(Homo
sapiens) 		4 / 5 ILE A 491
THR A 447
PHE A 446
PHE A 582
 None
 1.34A 3em0A-3p0uA:
undetectable		 3em0A-3p0uA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 3p0u NUCLEAR RECEPTOR
SUBFAMILY 2 GROUP C
MEMBER 2
(Homo
sapiens) 		5 / 12 ALA A 512
LEU A 514
LEU A 566
LEU A 569
LEU A 445
 None
 1.16A 3r9cA-3p0uA:
undetectable		 3r9cA-3p0uA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 3p0u NUCLEAR RECEPTOR
SUBFAMILY 2 GROUP C
MEMBER 2
(Homo
sapiens) 		4 / 7 ALA A 425
ILE A 533
LEU A 519
PHE A 520
 None
 1.08A 4uymA-3p0uA:
undetectable		 4uymA-3p0uA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AY6_A_VORA501_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 3p0u NUCLEAR RECEPTOR
SUBFAMILY 2 GROUP C
MEMBER 2
(Homo
sapiens) 		5 / 9 ALA A 502
ALA A 451
THR A 447
LEU A 569
LEU A 514
 None
 1.36A 6ay6A-3p0uA:
undetectable		 6ay6A-3p0uA:
20.48