SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3p13'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 3p13 D-RIBOSE PYRANASE
(Staphylococcus
aureus) 		5 / 12 ILE A  90
PHE A  53
GLN A  85
ILE A  75
ASN A  79
 None
 0.90A 1dhfB-3p13A:
undetectable		 1dhfB-3p13A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 3p13 D-RIBOSE PYRANASE
(Staphylococcus
aureus) 		5 / 12 ILE A  90
PHE A  53
ILE A  75
ASN A  79
LEU A  83
 None
 1.17A 1dhfB-3p13A:
undetectable		 1dhfB-3p13A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 3p13 D-RIBOSE PYRANASE
(Staphylococcus
aureus) 		5 / 12 ILE A  90
PHE A  53
GLN A  85
ILE A  75
ASN A  79
 None
 0.96A 1dlsA-3p13A:
undetectable		 1dlsA-3p13A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 3p13 D-RIBOSE PYRANASE
(Staphylococcus
aureus) 		5 / 12 ILE A  75
ALA A  72
LEU A  71
ARG A 118
VAL A  60
 None
 1.16A 1i9gA-3p13A:
undetectable		 1i9gA-3p13A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3p13 D-RIBOSE PYRANASE
(Staphylococcus
aureus) 		4 / 6 ARG A  52
GLN A  82
ASN A  79
ASN A 116
 None
 1.25A 2nyrA-3p13A:
undetectable		 2nyrA-3p13A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3p13 D-RIBOSE PYRANASE
(Staphylococcus
aureus) 		4 / 6 ARG A  52
GLN A  82
ASN A  79
LEU A 130
 None
 0.97A 2nyrA-3p13A:
undetectable		 2nyrA-3p13A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 3p13 D-RIBOSE PYRANASE
(Staphylococcus
aureus) 		5 / 12 ILE A  90
PHE A  53
GLN A  85
ILE A  75
ASN A  79
 None
 1.01A 2w3mA-3p13A:
undetectable		 2w3mA-3p13A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 3p13 D-RIBOSE PYRANASE
(Staphylococcus
aureus) 		5 / 12 ILE A  90
LEU A  61
ILE A  96
ILE A  28
PHE A  53
 None
 1.04A 2ygqA-3p13A:
undetectable		 2ygqA-3p13A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 3p13 D-RIBOSE PYRANASE
(Staphylococcus
aureus) 		5 / 11 VAL A  60
LEU A  44
SER A  14
ILE A  42
ALA A 129
 None
 1.23A 2zbzA-3p13A:
undetectable		 2zbzA-3p13A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 3p13 D-RIBOSE PYRANASE
(Staphylococcus
aureus) 		5 / 12 ILE A  90
PHE A  53
GLN A  85
ILE A  75
ASN A  79
 None
 0.96A 4kebB-3p13A:
undetectable		 4kebB-3p13A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 3p13 D-RIBOSE PYRANASE
(Staphylococcus
aureus) 		3 / 3 LYS A 114
ASN A  29
ASP A  24
 None
 0.84A 4o1eA-3p13A:
undetectable		 4o1eA-3p13A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 3p13 D-RIBOSE PYRANASE
(Staphylococcus
aureus) 		3 / 3 ASN A  79
SER A 126
ARG A  52
 None
 0.68A 5b2qA-3p13A:
undetectable		 5b2qA-3p13A:
6.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3p13 D-RIBOSE PYRANASE
(Staphylococcus
aureus) 		4 / 7 ARG A  52
GLY A 120
THR A 123
GLU A 121
 None
 0.90A 5bs8A-3p13A:
undetectable
5bs8B-3p13A:
undetectable
5bs8C-3p13A:
undetectable		 5bs8A-3p13A:
14.83
5bs8B-3p13A:
21.26
5bs8C-3p13A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3p13 D-RIBOSE PYRANASE
(Staphylococcus
aureus) 		4 / 7 ARG A  52
GLY A 120
THR A 123
GLU A 121
 None
 0.92A 5btaA-3p13A:
undetectable
5btaC-3p13A:
undetectable
5btaD-3p13A:
undetectable		 5btaA-3p13A:
15.01
5btaC-3p13A:
15.01
5btaD-3p13A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3p13 D-RIBOSE PYRANASE
(Staphylococcus
aureus) 		4 / 6 ARG A  52
GLY A 120
THR A 123
GLU A 121
 None
 0.91A 5btaA-3p13A:
undetectable
5btaB-3p13A:
undetectable
5btaC-3p13A:
undetectable		 5btaA-3p13A:
15.01
5btaB-3p13A:
21.26
5btaC-3p13A:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3p13 D-RIBOSE PYRANASE
(Staphylococcus
aureus) 		4 / 6 ARG A  52
GLY A 120
THR A 123
GLU A 121
 None
 0.96A 5btcA-3p13A:
undetectable
5btcC-3p13A:
undetectable
5btcD-3p13A:
undetectable		 5btcA-3p13A:
15.01
5btcC-3p13A:
15.01
5btcD-3p13A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3p13 D-RIBOSE PYRANASE
(Staphylococcus
aureus) 		4 / 6 ARG A  52
GLY A 120
THR A 123
GLU A 121
 None
 0.93A 5btcA-3p13A:
undetectable
5btcB-3p13A:
undetectable
5btcC-3p13A:
undetectable		 5btcA-3p13A:
15.01
5btcB-3p13A:
21.26
5btcC-3p13A:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3p13 D-RIBOSE PYRANASE
(Staphylococcus
aureus) 		4 / 7 ARG A  52
GLY A 120
THR A 123
GLU A 121
 None
 0.90A 5btdA-3p13A:
undetectable
5btdB-3p13A:
undetectable
5btdC-3p13A:
undetectable		 5btdA-3p13A:
14.83
5btdB-3p13A:
21.26
5btdC-3p13A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3p13 D-RIBOSE PYRANASE
(Staphylococcus
aureus) 		4 / 7 ARG A  52
GLY A 120
THR A 123
GLU A 121
 None
 0.92A 5btfA-3p13A:
undetectable
5btfB-3p13A:
undetectable
5btfC-3p13A:
undetectable		 5btfA-3p13A:
15.01
5btfB-3p13A:
21.26
5btfC-3p13A:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3p13 D-RIBOSE PYRANASE
(Staphylococcus
aureus) 		4 / 6 ARG A  52
GLY A 120
THR A 123
GLU A 121
 None
 0.92A 5btgA-3p13A:
undetectable
5btgB-3p13A:
undetectable
5btgC-3p13A:
undetectable		 5btgA-3p13A:
14.83
5btgB-3p13A:
21.26
5btgC-3p13A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 3p13 D-RIBOSE PYRANASE
(Staphylococcus
aureus) 		3 / 3 THR A  27
PRO A  51
ARG A  52
 None
 0.69A 5nd7B-3p13A:
undetectable		 5nd7B-3p13A:
14.38