SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3p1t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 3p1t PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Burkholderia
pseudomallei) 		4 / 8 PHE A 195
LEU A 240
TYR A 199
LEU A  70
 None
 0.81A 2bfpB-3p1tA:
undetectable		 2bfpB-3p1tA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 3p1t PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Burkholderia
pseudomallei) 		3 / 3 LEU A 326
ASN A 322
ARG A 259
 None
 0.86A 2qhfA-3p1tA:
undetectable		 2qhfA-3p1tA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3p1t PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Burkholderia
pseudomallei) 		5 / 9 PHE A 210
LEU A 236
LEU A  72
ALA A 208
PHE A 195
 None
 1.19A 2vcvD-3p1tA:
undetectable		 2vcvD-3p1tA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3p1t PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Burkholderia
pseudomallei) 		5 / 9 PHE A 210
LEU A 236
LEU A  72
ALA A 208
PHE A 195
 None
 1.23A 2vcvE-3p1tA:
undetectable		 2vcvE-3p1tA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3p1t PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Burkholderia
pseudomallei) 		5 / 9 PHE A 210
LEU A 236
LEU A  72
ALA A 208
PHE A 195
 None
 1.19A 2vcvH-3p1tA:
undetectable		 2vcvH-3p1tA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3p1t PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Burkholderia
pseudomallei) 		5 / 9 PHE A 210
LEU A 236
LEU A  72
ALA A 208
PHE A 195
 None
 1.17A 2vcvI-3p1tA:
undetectable		 2vcvI-3p1tA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3p1t PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Burkholderia
pseudomallei) 		4 / 6 LEU A 156
ARG A 181
ILE A 168
ILE A 216
 None
 0.95A 2xkwB-3p1tA:
undetectable		 2xkwB-3p1tA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 3p1t PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Burkholderia
pseudomallei) 		5 / 11 LEU A 325
LEU A 264
VAL A 281
ILE A 316
THR A 289
 None
 1.22A 3jw5A-3p1tA:
undetectable		 3jw5A-3p1tA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 3p1t PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Burkholderia
pseudomallei) 		3 / 3 GLU A 237
LEU A 240
ASP A 241
 None
 0.37A 3ko0T-3p1tA:
undetectable		 3ko0T-3p1tA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 3p1t PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Burkholderia
pseudomallei) 		3 / 3 PRO A 143
SER A 274
ASN A 145
 None
None
TLA  A 343 (-3.3A)
 0.81A 3lslG-3p1tA:
undetectable		 3lslG-3p1tA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 3p1t PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Burkholderia
pseudomallei) 		3 / 3 ALA A  28
VAL A  29
GLN A  34
 None
 0.73A 3of4B-3p1tA:
undetectable		 3of4B-3p1tA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 3p1t PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Burkholderia
pseudomallei) 		5 / 12 ILE A 316
LEU A 326
LEU A 329
VAL A 271
VAL A 281
 None
 1.07A 4c9oB-3p1tA:
undetectable		 4c9oB-3p1tA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 3p1t PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Burkholderia
pseudomallei) 		4 / 6 PHE A 195
SER A 196
ARG A 205
GLY A 203
 None
None
TLA  A 343 ( 4.1A)
None
 1.12A 5o4yF-3p1tA:
undetectable		 5o4yF-3p1tA:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 3p1t PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Burkholderia
pseudomallei) 		4 / 8 PHE A 195
PHE A  63
HIS A  62
SER A 198
 None
 1.02A 6huoC-3p1tA:
undetectable
6huoD-3p1tA:
undetectable		 6huoC-3p1tA:
11.31
6huoD-3p1tA:
15.71