SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3p1w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 3p1w RABGDI PROTEIN
(Plasmodium
falciparum) 		4 / 8 GLY A  13
GLY A  41
TYR A 417
VAL A 297
 None
 0.79A 1dbbH-3p1wA:
undetectable
1dbbL-3p1wA:
undetectable		 1dbbH-3p1wA:
19.46
1dbbL-3p1wA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 3p1w RABGDI PROTEIN
(Plasmodium
falciparum) 		4 / 8 VAL A 356
ASN A  72
GLY A  40
LEU A  14
 None
 0.89A 1dzmA-3p1wA:
1.8		 1dzmA-3p1wA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 3p1w RABGDI PROTEIN
(Plasmodium
falciparum) 		4 / 6 ASP A 131
TYR A 220
PHE A 151
LEU A 193
 None
 1.17A 2w98A-3p1wA:
undetectable
2w98B-3p1wA:
undetectable		 2w98A-3p1wA:
20.37
2w98B-3p1wA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 3p1w RABGDI PROTEIN
(Plasmodium
falciparum) 		5 / 12 ILE A 311
ALA A  44
ASP A  74
VAL A 394
LEU A  51
 None
 0.99A 2yqzA-3p1wA:
undetectable		 2yqzA-3p1wA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3p1w RABGDI PROTEIN
(Plasmodium
falciparum) 		4 / 4 ILE A 124
GLN A 338
ILE A 347
LEU A 188
 None
 1.26A 3dzyD-3p1wA:
undetectable		 3dzyD-3p1wA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 3p1w RABGDI PROTEIN
(Plasmodium
falciparum) 		4 / 8 TYR A 220
GLU A 133
PHE A 232
ILE A 233
 None
 0.95A 3jz0B-3p1wA:
undetectable		 3jz0B-3p1wA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 3p1w RABGDI PROTEIN
(Plasmodium
falciparum) 		3 / 3 GLN A 326
THR A 327
LEU A 385
 None
 0.67A 3ondA-3p1wA:
undetectable		 3ondA-3p1wA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 3p1w RABGDI PROTEIN
(Plasmodium
falciparum) 		3 / 3 GLN A 326
THR A 327
LEU A 385
 None
 0.66A 3ondB-3p1wA:
undetectable		 3ondB-3p1wA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 3p1w RABGDI PROTEIN
(Plasmodium
falciparum) 		4 / 8 TYR A 286
CYH A 287
ILE A 411
ILE A 277
 None
 1.00A 4afgD-3p1wA:
undetectable
4afgE-3p1wA:
undetectable		 4afgD-3p1wA:
18.50
4afgE-3p1wA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 3p1w RABGDI PROTEIN
(Plasmodium
falciparum) 		5 / 9 LEU A 140
ALA A 134
PHE A 192
THR A 189
LEU A 185
 None
 1.38A 4ltwA-3p1wA:
undetectable		 4ltwA-3p1wA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 3p1w RABGDI PROTEIN
(Plasmodium
falciparum) 		5 / 12 ILE A 242
VAL A  87
LEU A  14
PHE A 246
THR A  93
 None
 1.17A 5bykA-3p1wA:
undetectable		 5bykA-3p1wA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 3p1w RABGDI PROTEIN
(Plasmodium
falciparum) 		4 / 5 VAL A 350
VAL A 104
GLY A 106
PHE A  79
 None
 0.79A 5d4nA-3p1wA:
1.6
5d4nC-3p1wA:
1.8		 5d4nA-3p1wA:
12.00
5d4nC-3p1wA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3p1w RABGDI PROTEIN
(Plasmodium
falciparum) 		4 / 7 ILE A 333
GLN A 331
ALA A 368
THR A 369
 None
 0.75A 6cduC-3p1wA:
undetectable
6cduD-3p1wA:
undetectable		 6cduC-3p1wA:
21.44
6cduD-3p1wA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3p1w RABGDI PROTEIN
(Plasmodium
falciparum) 		4 / 8 ILE A 333
GLN A 331
ALA A 368
THR A 369
 None
 0.74A 6cduD-3p1wA:
undetectable
6cduE-3p1wA:
undetectable		 6cduD-3p1wA:
21.44
6cduE-3p1wA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3p1w RABGDI PROTEIN
(Plasmodium
falciparum) 		4 / 7 ALA A 368
THR A 369
ILE A 333
GLN A 331
 None
 0.81A 6cduF-3p1wA:
undetectable
6cduJ-3p1wA:
undetectable		 6cduF-3p1wA:
21.44
6cduJ-3p1wA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3p1w RABGDI PROTEIN
(Plasmodium
falciparum) 		5 / 9 PRO A 243
GLY A  13
SER A  20
LEU A 259
LEU A  33
 None
 1.48A 6dm0A-3p1wA:
undetectable
6dm0D-3p1wA:
undetectable		 6dm0A-3p1wA:
10.48
6dm0D-3p1wA:
10.48