SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3p1z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 3p1z PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aeropyrum
pernix) 		4 / 8 LEU A  36
VAL A  24
GLY A  45
TYR A  32
 None
 0.97A 1jlfA-3p1zA:
undetectable
1jlfB-3p1zA:
undetectable		 1jlfA-3p1zA:
16.38
1jlfB-3p1zA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 3p1z PUTATIVE
UNCHARACTERIZED
PROTEIN
TRNA-SPLICING
ENDONUCLEASE
(Aeropyrum
pernix;
Aeropyrum
pernix) 		3 / 3 PHE B 184
TYR A 110
PRO B 186
 None
 1.01A 1mcnA-3p1zB:
undetectable
1mcnB-3p1zB:
undetectable
1mcnP-3p1zB:
undetectable		 1mcnA-3p1zB:
22.71
1mcnB-3p1zB:
22.71
1mcnP-3p1zB:
1.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 3p1z TRNA-SPLICING
ENDONUCLEASE
(Aeropyrum
pernix) 		5 / 11 ALA B  88
GLU B  83
GLU B  66
ALA B  65
LEU B  62
 None
 1.25A 1mjlA-3p1zB:
undetectable
1mjlB-3p1zB:
undetectable		 1mjlA-3p1zB:
20.00
1mjlB-3p1zB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_1
(PROTEASE RETROPEPSIN)		 3p1z PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aeropyrum
pernix) 		5 / 10 GLY A 139
ALA A 140
ASP A 143
GLY A 102
VAL A 149
 None
 0.98A 1t3rA-3p1zA:
undetectable		 1t3rA-3p1zA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 3p1z PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aeropyrum
pernix) 		5 / 12 GLY A 139
ALA A 140
ASP A 143
GLY A 102
VAL A 149
 None
 0.84A 2fxeA-3p1zA:
undetectable		 2fxeA-3p1zA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 3p1z PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aeropyrum
pernix) 		3 / 3 TYR A 160
VAL A  88
THR A 159
 None
 0.76A 2ygnA-3p1zA:
undetectable		 2ygnA-3p1zA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 3p1z PUTATIVE
UNCHARACTERIZED
PROTEIN
TRNA-SPLICING
ENDONUCLEASE
(Aeropyrum
pernix) 		5 / 10 VAL B 150
ALA B 155
ILE B 181
PRO A 147
ILE A 151
 None
 1.26A 3clbD-3p1zB:
undetectable		 3clbD-3p1zB:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3p1z PUTATIVE
UNCHARACTERIZED
PROTEIN
TRNA-SPLICING
ENDONUCLEASE
(Aeropyrum
pernix;
Aeropyrum
pernix) 		5 / 9 GLN A 170
ASP B 104
ILE B 101
VAL B 138
VAL B 167
 None
 1.23A 3fi0C-3p1zA:
undetectable		 3fi0C-3p1zA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3p1z PUTATIVE
UNCHARACTERIZED
PROTEIN
TRNA-SPLICING
ENDONUCLEASE
(Aeropyrum
pernix) 		5 / 10 VAL B 150
ALA B 155
ILE B 181
PRO A 147
ILE A 151
 None
 1.25A 3hbbD-3p1zB:
undetectable		 3hbbD-3p1zB:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_A_T3A1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 3p1z PUTATIVE
UNCHARACTERIZED
PROTEIN
TRNA-SPLICING
ENDONUCLEASE
(Aeropyrum
pernix) 		5 / 12 VAL B 138
PHE B 136
VAL B 112
PHE B 110
SER A 168
 None
 1.47A 4bvaA-3p1zB:
undetectable		 4bvaA-3p1zB:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 3p1z PUTATIVE
UNCHARACTERIZED
PROTEIN
TRNA-SPLICING
ENDONUCLEASE
(Aeropyrum
pernix) 		3 / 3 TYR B 178
ARG A 167
SER B 177
 None
 1.18A 4dr2I-3p1zB:
undetectable
4dr2J-3p1zB:
undetectable		 4dr2I-3p1zB:
23.04
4dr2J-3p1zB:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 3p1z PUTATIVE
UNCHARACTERIZED
PROTEIN
TRNA-SPLICING
ENDONUCLEASE
(Aeropyrum
pernix) 		5 / 12 LEU B 158
GLY B 156
VAL B 167
ILE A 151
VAL A 149
 None
 1.33A 4okwA-3p1zB:
undetectable		 4okwA-3p1zB:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_1
(ASPARTYL PROTEASE)		 3p1z PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aeropyrum
pernix) 		5 / 9 GLY A 139
ALA A 140
ASP A 143
GLY A 102
VAL A 149
 None
 1.02A 4q1wA-3p1zA:
undetectable		 4q1wA-3p1zA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_0
(HIV-1 PROTEASE)		 3p1z PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aeropyrum
pernix) 		5 / 12 GLY A 139
ALA A 140
ASP A 143
GLY A 102
VAL A 149
 None
 0.74A 6dj1A-3p1zA:
undetectable		 6dj1A-3p1zA:
17.75