SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3p27'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_B_CAMB502_0
(CYTOCHROME P450-CAM)		 3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
(Saccharomyces
cerevisiae) 		5 / 9 PHE A 401
LEU A 478
VAL A 447
THR A 149
VAL A 495
 None
 1.48A 1dz8B-3p27A:
undetectable		 1dz8B-3p27A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 204
ILE A 219
TRP A 218
 None
 1.14A 1m8eB-3p27A:
undetectable		 1m8eB-3p27A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 319
THR A 365
GLU A 367
GLU A 357
 None
 1.40A 2dttB-3p27A:
undetectable
2dttC-3p27A:
undetectable		 2dttB-3p27A:
13.18
2dttC-3p27A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 303
ALA A 262
ASP A 251
VAL A 171
GLY A 174
ILE A 266
 None
 1.48A 2ienA-3p27A:
undetectable		 2ienA-3p27A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 420
VAL A 421
THR A 475
ASP A 448
 None
 1.00A 2qblA-3p27A:
undetectable		 2qblA-3p27A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 SER A 352
HIS A 175
ASP A 288
 GDP  A 663 (-2.6A)
None
None
 0.80A 2wa2B-3p27A:
undetectable		 2wa2B-3p27A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 377
ILE A 273
ILE A 339
LEU A 333
 None
 0.95A 2xkwB-3p27A:
undetectable		 2xkwB-3p27A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 MET A 315
VAL A 349
ALA A 311
GLU A 357
THR A 380
 None
 1.29A 3dl9B-3p27A:
undetectable		 3dl9B-3p27A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 204
ILE A 219
TRP A 218
 None
 1.09A 3e68A-3p27A:
undetectable		 3e68A-3p27A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 204
ILE A 219
TRP A 218
 None
 1.16A 3e6tB-3p27A:
undetectable		 3e6tB-3p27A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 464
ASP A 466
ASP A 448
 None
 0.47A 3jb2A-3p27A:
undetectable		 3jb2A-3p27A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 492
GLU A 434
ILE A 430
GLY A 428
PHE A 401
 None
 1.01A 3k2hA-3p27A:
undetectable		 3k2hA-3p27A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 492
GLU A 434
ILE A 430
GLY A 428
PHE A 401
 None
 1.00A 3k2hB-3p27A:
undetectable		 3k2hB-3p27A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 MET A 312
GLY A 174
MET A 297
LEU A 308
ILE A 328
 None
 1.47A 3mneA-3p27A:
undetectable		 3mneA-3p27A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 556
HIS A 558
PRO A 521
LEU A 541
 None
 1.21A 3oi8A-3p27A:
undetectable		 3oi8A-3p27A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 407
LEU A 406
GLN A 456
GLY A 423
 None
 1.24A 3pp1A-3p27A:
undetectable		 3pp1A-3p27A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 170
ALA A 384
ALA A 245
THR A 242
 None
 0.84A 3t3sD-3p27A:
undetectable		 3t3sD-3p27A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
(Saccharomyces
cerevisiae) 		5 / 8 PHE A 170
ALA A 384
PHE A 240
ALA A 245
THR A 242
 None
 0.95A 3t3sF-3p27A:
undetectable		 3t3sF-3p27A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 ASP A 338
VAL A 337
GLY A 340
TYR A 335
 None
 1.49A 3w9tA-3p27A:
undetectable		 3w9tA-3p27A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 ASP A 338
VAL A 337
GLY A 340
TYR A 335
 None
 1.48A 3w9tC-3p27A:
undetectable		 3w9tC-3p27A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 ASP A 338
VAL A 337
GLY A 340
TYR A 335
 None
 1.49A 3w9tD-3p27A:
undetectable		 3w9tD-3p27A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 ASP A 338
VAL A 337
GLY A 340
TYR A 335
 None
 1.49A 3w9tE-3p27A:
undetectable		 3w9tE-3p27A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)		 3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 ASP A 338
VAL A 337
GLY A 340
TYR A 335
 None
 1.48A 3w9tF-3p27A:
undetectable		 3w9tF-3p27A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 ASP A 338
VAL A 337
GLY A 340
TYR A 335
 None
 1.49A 3w9tG-3p27A:
undetectable		 3w9tG-3p27A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 SER A 169
LEU A 402
LEU A 406
GLY A 423
PHE A 473
 None
 1.15A 4foxA-3p27A:
undetectable		 4foxA-3p27A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 SER A 169
LEU A 402
LEU A 406
GLY A 423
PHE A 473
 None
 1.11A 4foxB-3p27A:
undetectable		 4foxB-3p27A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
(Saccharomyces
cerevisiae) 		5 / 11 SER A 169
LEU A 402
LEU A 406
GLY A 423
PHE A 473
 None
 1.14A 4foxC-3p27A:
undetectable		 4foxC-3p27A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 SER A 169
LEU A 402
LEU A 406
GLY A 423
PHE A 473
 None
 1.15A 4foxG-3p27A:
undetectable		 4foxG-3p27A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 589
PRO A 579
GLU A 426
TYR A 497
 None
 0.88A 4lb2A-3p27A:
undetectable		 4lb2A-3p27A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 289
LEU A 336
ILE A 339
ASP A 338
 None
 0.87A 4rmjA-3p27A:
2.1		 4rmjA-3p27A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 590
ILE A 606
ILE A 526
ARG A 595
ALA A 536
 None
 0.93A 5e72A-3p27A:
undetectable		 5e72A-3p27A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 305
GLY A 304
SER A 301
ALA A 300
ALA A 272
 None
 0.98A 5n0oB-3p27A:
undetectable		 5n0oB-3p27A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 THR A 248
HIS A 167
ASN A 246
 None
 0.94A 5n4tA-3p27A:
undetectable		 5n4tA-3p27A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 353
ILE A 362
ASP A 190
TYR A 189
 GDP  A 663 (-3.6A)
None
None
None
 0.97A 5vlmC-3p27A:
undetectable		 5vlmC-3p27A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 296
VAL A 171
LEU A 173
ALA A 262
 None
 1.22A 6d8pB-3p27A:
3.0		 6d8pB-3p27A:
20.15