SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3p2m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 3p2m POSSIBLE HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 109
HIS A  95
LEU A  75
ALA A  94
GLY A 117
 None
 1.40A 1cmcA-3p2mA:
undetectable
1cmcB-3p2mA:
undetectable		 1cmcA-3p2mA:
15.96
1cmcB-3p2mA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 3p2m POSSIBLE HYDROLASE
(Mycobacterium
tuberculosis) 		4 / 4 LEU A  61
PRO A  62
LEU A  48
ARG A 231
 None
 1.32A 1hrkB-3p2mA:
2.4		 1hrkB-3p2mA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		 3p2m POSSIBLE HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 9 HIS A  95
ASN A  93
ALA A  46
LEU A  47
LEU A  42
 None
 1.37A 1hwiA-3p2mA:
undetectable		 1hwiA-3p2mA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 3p2m POSSIBLE HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 10 VAL A 283
TRP A 262
LEU A 274
LEU A 291
ALA A 183
 None
 1.42A 1pbcA-3p2mA:
undetectable		 1pbcA-3p2mA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBF_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 3p2m POSSIBLE HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 9 VAL A 283
TRP A 262
LEU A 274
LEU A 291
ALA A 183
 None
 1.41A 1pbfA-3p2mA:
undetectable		 1pbfA-3p2mA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 3p2m POSSIBLE HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 10 ASP A 112
TRP A  97
GLY A 157
GLY A 156
SER A 154
 None
 1.15A 1w76B-3p2mA:
12.0		 1w76B-3p2mA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 3p2m POSSIBLE HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 10 GLY A  89
GLY A  90
SER A 154
PHE A 255
HIS A 309
 None
 1.12A 1w76B-3p2mA:
12.0		 1w76B-3p2mA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 3p2m POSSIBLE HYDROLASE
(Mycobacterium
tuberculosis) 		4 / 4 LEU A  61
PRO A  62
LEU A  48
ARG A 231
 None
 1.22A 2hrcA-3p2mA:
2.5		 2hrcA-3p2mA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 3p2m POSSIBLE HYDROLASE
(Mycobacterium
tuberculosis) 		4 / 4 LEU A  61
PRO A  62
LEU A  48
ARG A 231
 None
 1.38A 2hrcB-3p2mA:
3.2		 2hrcB-3p2mA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3p2m POSSIBLE HYDROLASE
(Mycobacterium
tuberculosis) 		4 / 4 LEU A  61
PRO A  62
LEU A  48
ARG A 231
 None
 1.20A 2pnjB-3p2mA:
3.2		 2pnjB-3p2mA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 3p2m POSSIBLE HYDROLASE
(Mycobacterium
tuberculosis) 		4 / 4 LEU A  61
PRO A  62
LEU A  48
ARG A 231
 None
 1.27A 2qd2A-3p2mA:
3.6		 2qd2A-3p2mA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 3p2m POSSIBLE HYDROLASE
(Mycobacterium
tuberculosis) 		3 / 3 LEU A  61
PRO A  62
ARG A 231
 None
 0.60A 2qd4B-3p2mA:
3.3		 2qd4B-3p2mA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 3p2m POSSIBLE HYDROLASE
(Mycobacterium
tuberculosis) 		3 / 3 LEU A  61
PRO A  62
ARG A 231
 None
 0.61A 2qd5A-3p2mA:
3.5		 2qd5A-3p2mA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3p2m POSSIBLE HYDROLASE
(Mycobacterium
tuberculosis) 		3 / 3 ASN A  93
ARG A 248
ASP A  43
 None
 0.81A 2qe6A-3p2mA:
undetectable		 2qe6A-3p2mA:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3p2m POSSIBLE HYDROLASE
(Mycobacterium
tuberculosis) 		3 / 3 ASN A  93
ARG A 248
ASP A  43
 None
 0.79A 2qe6B-3p2mA:
2.1		 2qe6B-3p2mA:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3p2m POSSIBLE HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 167
PRO A 168
VAL A 171
ILE A 161
ASP A 264
 None
 1.30A 2v95A-3p2mA:
undetectable		 2v95A-3p2mA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3p2m POSSIBLE HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 161
ALA A 165
LEU A 268
ALA A 267
VAL A 179
 None
 1.06A 3dzyA-3p2mA:
undetectable		 3dzyA-3p2mA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3p2m POSSIBLE HYDROLASE
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 140
PRO A 114
SER A 119
GLY A 156
 None
 1.01A 3hcnA-3p2mA:
3.3		 3hcnA-3p2mA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3p2m POSSIBLE HYDROLASE
(Mycobacterium
tuberculosis) 		4 / 4 LEU A  61
PRO A  62
LEU A  48
ARG A 231
 None
 1.21A 3hcoB-3p2mA:
3.5		 3hcoB-3p2mA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 3p2m POSSIBLE HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 7 GLY A  89
GLY A  90
SER A 154
PHE A 282
HIS A 309
 None
 1.18A 3o9mA-3p2mA:
12.8		 3o9mA-3p2mA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 3p2m POSSIBLE HYDROLASE
(Mycobacterium
tuberculosis) 		4 / 7 SER A 310
GLY A 117
ASP A 112
GLU A  44
 None
 0.86A 4koeA-3p2mA:
undetectable
4koeB-3p2mA:
undetectable
4koeD-3p2mA:
3.9		 4koeA-3p2mA:
20.24
4koeB-3p2mA:
20.24
4koeD-3p2mA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3p2m POSSIBLE HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 109
ALA A 144
ALA A  69
VAL A  67
ALA A  74
 None
 0.95A 4x20B-3p2mA:
3.9		 4x20B-3p2mA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 3p2m POSSIBLE HYDROLASE
(Mycobacterium
tuberculosis) 		4 / 6 ARG A 186
ARG A 276
ASP A 178
ASP A 287
 None
 1.36A 4xqeA-3p2mA:
3.4		 4xqeA-3p2mA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 3p2m POSSIBLE HYDROLASE
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 117
ASP A 112
GLU A  44
SER A 310
 None
 0.91A 4z53A-3p2mA:
2.8
4z53B-3p2mA:
2.2		 4z53A-3p2mA:
18.70
4z53B-3p2mA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 3p2m POSSIBLE HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 9 ASN A 236
HIS A  88
TYR A 249
GLY A  91
GLY A  90
 None
 1.31A 5f8yA-3p2mA:
undetectable		 5f8yA-3p2mA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA203_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 3p2m POSSIBLE HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 9 HIS A  88
TYR A 249
GLY A  91
GLY A  90
ASN A 236
 None
 1.28A 5f8yA-3p2mA:
undetectable		 5f8yA-3p2mA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 3p2m POSSIBLE HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 9 HIS A  88
TYR A 249
GLY A  91
GLY A  90
ASN A 236
 None
 1.28A 5f8yB-3p2mA:
undetectable		 5f8yB-3p2mA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB203_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 3p2m POSSIBLE HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 9 ASN A 236
HIS A  88
TYR A 249
GLY A  91
GLY A  90
 None
 1.29A 5f8yB-3p2mA:
undetectable		 5f8yB-3p2mA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 3p2m POSSIBLE HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 157
GLY A 281
VAL A 283
GLY A  90
GLY A  89
 None
 0.95A 5koxA-3p2mA:
undetectable		 5koxA-3p2mA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3p2m POSSIBLE HYDROLASE
(Mycobacterium
tuberculosis) 		4 / 5 GLY A 125
ASN A 126
ASP A 124
ARG A 122
 None
 1.38A 6dwdB-3p2mA:
undetectable
6dwdD-3p2mA:
undetectable		 6dwdB-3p2mA:
24.60
6dwdD-3p2mA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 3p2m POSSIBLE HYDROLASE
(Mycobacterium
tuberculosis) 		4 / 5 PHE A  86
VAL A  67
PRO A 107
VAL A  84
 None
 1.35A 6ekzA-3p2mA:
undetectable		 6ekzA-3p2mA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 3p2m POSSIBLE HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 6 ALA A 183
SER A 154
GLY A 157
ILE A 272
PHE A 298
 None
 1.30A 6f8cA-3p2mA:
undetectable		 6f8cA-3p2mA:
14.33