SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3p3l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		4 / 7 GLY A 103
THR A 110
HIS A 107
THR A 106
 None
 0.81A 1c9sT-3p3lA:
undetectable
1c9sU-3p3lA:
undetectable		 1c9sT-3p3lA:
10.84
1c9sU-3p3lA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		4 / 7 GLY A 103
THR A 110
HIS A 107
THR A 106
 None
 0.88A 1gtfL-3p3lA:
undetectable
1gtfM-3p3lA:
undetectable		 1gtfL-3p3lA:
10.84
1gtfM-3p3lA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		4 / 8 GLY A 103
THR A 110
HIS A 107
THR A 106
 None
 0.87A 1gtfN-3p3lA:
undetectable
1gtfO-3p3lA:
undetectable		 1gtfN-3p3lA:
10.84
1gtfO-3p3lA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		5 / 11 LEU A 360
ALA A 373
ALA A 371
VAL A 121
LEU A 147
 HEM  A 501 (-4.3A)
None
None
None
None
 1.28A 1hbpA-3p3lA:
undetectable		 1hbpA-3p3lA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		4 / 8 CYH A 355
HIS A  98
LEU A  90
LEU A 236
 HEM  A 501 (-2.4A)
HEM  A 501 ( 3.8A)
HEM  A 501 (-4.2A)
None
 0.87A 1hwiD-3p3lA:
undetectable		 1hwiD-3p3lA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		4 / 8 CYH A 355
HIS A  98
LEU A  90
LEU A 236
 HEM  A 501 (-2.4A)
HEM  A 501 ( 3.8A)
HEM  A 501 (-4.2A)
None
 0.87A 1hwiC-3p3lA:
undetectable		 1hwiC-3p3lA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		3 / 3 ALA A 319
VAL A 321
TRP A  26
 None
 0.95A 1jo4A-3p3lA:
undetectable		 1jo4A-3p3lA:
4.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		3 / 3 ALA A 319
VAL A 321
TRP A  26
 None
 0.95A 1jo4B-3p3lA:
undetectable		 1jo4B-3p3lA:
4.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		3 / 3 ALA A 319
VAL A 321
TRP A  26
 None
 0.93A 1magA-3p3lA:
undetectable		 1magA-3p3lA:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		3 / 3 ALA A 319
VAL A 321
TRP A  26
 None
 0.93A 1magB-3p3lA:
undetectable		 1magB-3p3lA:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		5 / 11 GLU A 205
VAL A 201
ILE A 204
LEU A 101
LEU A 236
 None
 1.34A 1mrqA-3p3lA:
undetectable		 1mrqA-3p3lA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		3 / 3 ALA A 319
VAL A 321
TRP A  26
 None
 0.83A 1nrmA-3p3lA:
undetectable		 1nrmA-3p3lA:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		3 / 3 ALA A 319
VAL A 321
TRP A  26
 None
 0.83A 1nrmB-3p3lA:
undetectable		 1nrmB-3p3lA:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA6_0
(GRAMICIDIN A)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		3 / 3 ALA A 319
VAL A 321
TRP A  26
 None
 0.79A 1nt5A-3p3lA:
undetectable		 1nt5A-3p3lA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB6_0
(GRAMICIDIN A)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		3 / 3 ALA A 319
VAL A 321
TRP A  26
 None
 0.79A 1nt5B-3p3lA:
undetectable		 1nt5B-3p3lA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		4 / 7 SER A 345
ARG A 362
LEU A 365
THR A 358
 None
 1.13A 2f78A-3p3lA:
undetectable		 2f78A-3p3lA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		4 / 5 GLN A  91
PHE A  89
PHE A  85
GLY A 176
 HEM  A 501 (-4.3A)
None
None
None
 0.72A 2qmzA-3p3lA:
undetectable
2qmzB-3p3lA:
undetectable		 2qmzA-3p3lA:
20.92
2qmzB-3p3lA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		4 / 7 THR A 295
GLN A  91
PHE A  89
PHE A  85
 None
HEM  A 501 (-4.3A)
None
None
 0.74A 2qx4A-3p3lA:
undetectable
2qx4B-3p3lA:
undetectable		 2qx4A-3p3lA:
20.92
2qx4B-3p3lA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		4 / 6 GLY A 176
GLN A  91
PHE A  89
PHE A  85
 None
HEM  A 501 (-4.3A)
None
None
 0.72A 2qx6A-3p3lA:
undetectable
2qx6B-3p3lA:
undetectable		 2qx6A-3p3lA:
20.92
2qx6B-3p3lA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		5 / 10 PHE A  89
ALA A 243
THR A 247
LEU A 290
VAL A 393
 None
HEM  A 501 (-3.5A)
HEM  A 501 (-3.6A)
HEM  A 501 (-4.5A)
None
 0.66A 2wuzA-3p3lA:
30.6		 2wuzA-3p3lA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		5 / 10 PHE A  89
ALA A 243
THR A 247
LEU A 290
VAL A 393
 None
HEM  A 501 (-3.5A)
HEM  A 501 (-3.6A)
HEM  A 501 (-4.5A)
None
 0.67A 2wuzB-3p3lA:
29.9		 2wuzB-3p3lA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		4 / 7 PHE A  89
ALA A 243
THR A 247
LEU A 290
 None
HEM  A 501 (-3.5A)
HEM  A 501 (-3.6A)
HEM  A 501 (-4.5A)
 0.87A 2wx2A-3p3lA:
29.8		 2wx2A-3p3lA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		4 / 4 TYR A 163
LEU A 160
LEU A 150
HIS A 145
 None
 1.48A 2x7hB-3p3lA:
undetectable		 2x7hB-3p3lA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		5 / 12 GLN A 251
THR A 247
GLY A 395
LEU A 254
GLU A 390
 HEM  A 501 (-4.6A)
HEM  A 501 (-3.6A)
None
None
None
 1.23A 2zw9B-3p3lA:
undetectable		 2zw9B-3p3lA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		5 / 12 VAL A 292
PHE A 354
VAL A 321
ALA A 294
LEU A  48
 None
EPE  A 409 (-3.8A)
None
HEM  A 501 ( 3.8A)
None
 1.35A 3dh0A-3p3lA:
undetectable		 3dh0A-3p3lA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		3 / 3 ALA A 243
THR A 247
CYH A 355
 HEM  A 501 (-3.5A)
HEM  A 501 (-3.6A)
HEM  A 501 (-2.4A)
 0.43A 3e4eA-3p3lA:
31.2		 3e4eA-3p3lA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		3 / 3 ALA A 243
THR A 247
CYH A 355
 HEM  A 501 (-3.5A)
HEM  A 501 (-3.6A)
HEM  A 501 (-2.4A)
 0.33A 3e4eB-3p3lA:
27.8		 3e4eB-3p3lA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		3 / 3 CYH A 153
PRO A 148
ASP A 164
 None
 0.89A 3hlwB-3p3lA:
undetectable		 3hlwB-3p3lA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		4 / 8 PHE A  89
ALA A 243
THR A 247
LEU A 290
 None
HEM  A 501 (-3.5A)
HEM  A 501 (-3.6A)
HEM  A 501 (-4.5A)
 0.71A 3l4dA-3p3lA:
29.8		 3l4dA-3p3lA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		4 / 8 PHE A  89
ALA A 243
THR A 247
LEU A 290
 None
HEM  A 501 (-3.5A)
HEM  A 501 (-3.6A)
HEM  A 501 (-4.5A)
 0.69A 3l4dD-3p3lA:
18.3		 3l4dD-3p3lA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		4 / 6 GLY A  67
HIS A 353
SER A  66
THR A 295
 None
HEM  A 501 (-3.8A)
None
None
 1.14A 3tj7A-3p3lA:
undetectable
3tj7B-3p3lA:
undetectable		 3tj7A-3p3lA:
18.89
3tj7B-3p3lA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		5 / 12 THR A  20
PHE A  19
LEU A 179
VAL A  75
PHE A 316
 None
 1.48A 3u9fD-3p3lA:
undetectable
3u9fE-3p3lA:
undetectable		 3u9fD-3p3lA:
20.29
3u9fE-3p3lA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		5 / 11 THR A  20
PHE A  19
LEU A 179
VAL A  75
PHE A 316
 None
 1.46A 3u9fN-3p3lA:
undetectable
3u9fO-3p3lA:
undetectable		 3u9fN-3p3lA:
20.29
3u9fO-3p3lA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		3 / 3 ARG A  42
GLU A   8
THR A   7
 None
None
SO4  A 408 (-4.8A)
 0.82A 3v4tA-3p3lA:
undetectable		 3v4tA-3p3lA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		4 / 6 PHE A  68
ALA A 243
THR A 247
LEU A 290
 None
HEM  A 501 (-3.5A)
HEM  A 501 (-3.6A)
HEM  A 501 (-4.5A)
 0.87A 4ejgD-3p3lA:
31.0		 4ejgD-3p3lA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		4 / 8 GLN A  91
PHE A  89
PHE A  85
GLY A 176
 HEM  A 501 (-4.3A)
None
None
None
 0.65A 4fgjA-3p3lA:
undetectable
4fgjB-3p3lA:
undetectable		 4fgjA-3p3lA:
21.12
4fgjB-3p3lA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		4 / 6 GLU A 364
THR A 110
HIS A 107
LEU A 155
 HEM  A 501 (-4.3A)
None
None
None
 1.00A 4pgfA-3p3lA:
undetectable		 4pgfA-3p3lA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		3 / 3 CYH A 153
PRO A 148
ASP A 164
 None
 0.98A 4pm5A-3p3lA:
undetectable		 4pm5A-3p3lA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		4 / 6 ARG A  69
ASP A  97
VAL A  87
ASP A  88
 None
 1.41A 4xqeA-3p3lA:
undetectable		 4xqeA-3p3lA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		4 / 6 ARG A  69
ASP A  97
VAL A  87
ASP A  88
 None
 1.39A 4xqeB-3p3lA:
undetectable		 4xqeB-3p3lA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_2
(CALCINEURIN SUBUNIT
B, VARIANT
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		4 / 4 LEU A  71
MET A  74
VAL A  75
ASN A 181
 None
 0.99A 5b8iB-3p3lA:
0.3		 5b8iB-3p3lA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		4 / 8 GLY A 103
THR A 110
HIS A 107
THR A 106
 None
 0.86A 5eezL-3p3lA:
undetectable
5eezV-3p3lA:
undetectable		 5eezL-3p3lA:
10.84
5eezV-3p3lA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		4 / 8 GLY A 103
THR A 110
HIS A 107
THR A 106
 None
 0.86A 5ef1L-3p3lA:
undetectable
5ef1V-3p3lA:
undetectable		 5ef1L-3p3lA:
10.84
5ef1V-3p3lA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		4 / 8 GLY A 103
THR A 110
HIS A 107
THR A 106
 None
 0.86A 5ef2L-3p3lA:
undetectable
5ef2V-3p3lA:
undetectable		 5ef2L-3p3lA:
10.84
5ef2V-3p3lA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		5 / 12 GLY A  67
ARG A 296
LEU A  71
MET A  74
THR A  43
 None
HEM  A 501 (-2.9A)
None
None
None
 1.39A 5fhzA-3p3lA:
undetectable		 5fhzA-3p3lA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		3 / 3 THR A 293
PRO A 344
ARG A 341
 HEM  A 501 (-4.0A)
None
None
 0.86A 5nd7B-3p3lA:
undetectable		 5nd7B-3p3lA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		4 / 5 VAL A 321
ASP A 325
PRO A 326
ALA A 322
 None
 1.08A 5otrA-3p3lA:
undetectable		 5otrA-3p3lA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		5 / 12 LEU A  47
GLY A 312
VAL A 297
LEU A  64
ILE A  65
 None
 1.02A 6ectA-3p3lA:
undetectable		 6ectA-3p3lA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		5 / 12 LEU A  47
GLY A 312
VAL A 297
LEU A  64
ILE A  65
 None
 1.03A 6ecxA-3p3lA:
undetectable		 6ecxA-3p3lA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 3p3l CYTOCHROME P450
(Streptomyces
thioluteus) 		4 / 5 VAL A 393
PRO A 148
MET A 152
VAL A 166
 None
None
HEM  A 501 ( 3.9A)
None
 1.25A 6ekzA-3p3lA:
undetectable		 6ekzA-3p3lA:
12.00