SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3p3v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_1
(HIV-II PROTEASE)		 3p3v PTS SYSTEM,
N-ACETYLGALACTOSAMIN
E-SPECIFIC IIB
COMPONENT
(Streptococcus
pyogenes) 		6 / 12 ALA A  35
ASP A  89
ILE A  70
PRO A  99
ILE A   6
ILE A  82
 None
 1.23A 1hshA-3p3vA:
undetectable		 1hshA-3p3vA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3p3v PTS SYSTEM,
N-ACETYLGALACTOSAMIN
E-SPECIFIC IIB
COMPONENT
(Streptococcus
pyogenes) 		5 / 12 ILE A 117
THR A 118
ILE A 108
ASN A 104
ILE A 105
 None
 1.18A 3kpdB-3p3vA:
undetectable		 3kpdB-3p3vA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_1
(PROTEASE)		 3p3v PTS SYSTEM,
N-ACETYLGALACTOSAMIN
E-SPECIFIC IIB
COMPONENT
(Streptococcus
pyogenes) 		6 / 12 ALA A  35
ASP A  89
ILE A  70
PRO A  99
ILE A   6
ILE A  82
 None
 1.19A 3s54A-3p3vA:
undetectable		 3s54A-3p3vA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 3p3v PTS SYSTEM,
N-ACETYLGALACTOSAMIN
E-SPECIFIC IIB
COMPONENT
(Streptococcus
pyogenes) 		5 / 9 ALA A  35
ILE A   6
ILE A 103
ILE A  68
VAL A  67
 None
 1.13A 4nptA-3p3vA:
undetectable		 4nptA-3p3vA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 3p3v PTS SYSTEM,
N-ACETYLGALACTOSAMIN
E-SPECIFIC IIB
COMPONENT
(Streptococcus
pyogenes) 		5 / 8 LEU A  93
ASP A  89
ASN A  36
ALA A  35
VAL A  34
 None
None
PEG  A 202 ( 4.1A)
None
None
 1.27A 4zbqA-3p3vA:
undetectable		 4zbqA-3p3vA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_DIFA601_1
(SERUM ALBUMIN)		 3p3v PTS SYSTEM,
N-ACETYLGALACTOSAMIN
E-SPECIFIC IIB
COMPONENT
(Streptococcus
pyogenes) 		5 / 9 LEU A  93
ASP A  89
ASN A  36
ALA A  35
VAL A  34
 None
None
PEG  A 202 ( 4.1A)
None
None
 1.25A 5dbyA-3p3vA:
undetectable		 5dbyA-3p3vA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_2
(PROTEASE)		 3p3v PTS SYSTEM,
N-ACETYLGALACTOSAMIN
E-SPECIFIC IIB
COMPONENT
(Streptococcus
pyogenes) 		6 / 12 ALA A  35
ASP A  89
ILE A  70
PRO A  99
ILE A   6
ILE A  82
 None
 1.15A 5e5jB-3p3vA:
undetectable		 5e5jB-3p3vA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 3p3v PTS SYSTEM,
N-ACETYLGALACTOSAMIN
E-SPECIFIC IIB
COMPONENT
(Streptococcus
pyogenes) 		4 / 6 ILE A  82
ALA A  90
LEU A  93
ILE A  64
 None
 0.83A 5mvmB-3p3vA:
undetectable
5mvmC-3p3vA:
undetectable		 5mvmB-3p3vA:
17.37
5mvmC-3p3vA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 3p3v PTS SYSTEM,
N-ACETYLGALACTOSAMIN
E-SPECIFIC IIB
COMPONENT
(Streptococcus
pyogenes) 		4 / 6 ASN A  36
ALA A  35
VAL A  39
ASP A  89
 PEG  A 202 ( 4.1A)
None
None
None
 1.13A 5umd2-3p3vA:
undetectable
5umdF-3p3vA:
undetectable		 5umd2-3p3vA:
20.62
5umdF-3p3vA:
20.13