SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3p4e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Vibrio
cholerae) 		3 / 3 VAL A  89
ALA A  90
HIS A 191
 None
 0.54A 1q23C-3p4eA:
undetectable		 1q23C-3p4eA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Vibrio
cholerae) 		3 / 3 VAL A  89
ALA A  90
HIS A 191
 None
 0.53A 1q23H-3p4eA:
undetectable		 1q23H-3p4eA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Vibrio
cholerae) 		3 / 3 VAL A  89
ALA A  90
HIS A 191
 None
 0.59A 1q23G-3p4eA:
undetectable		 1q23G-3p4eA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Vibrio
cholerae) 		3 / 3 VAL A  89
ALA A  90
HIS A 191
 None
 0.62A 1q23L-3p4eA:
undetectable		 1q23L-3p4eA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Vibrio
cholerae) 		3 / 3 VAL A  89
ALA A  90
HIS A 191
 None
 0.54A 1q23J-3p4eA:
undetectable		 1q23J-3p4eA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Vibrio
cholerae) 		4 / 5 LEU A 104
LEU A  96
CYH A 131
THR A  34
 None
 1.42A 2oaxD-3p4eA:
undetectable		 2oaxD-3p4eA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Vibrio
cholerae) 		5 / 11 ALA A  90
VAL A  68
GLY A 130
ILE A 127
VAL A 157
 None
 1.15A 2uxpB-3p4eA:
undetectable		 2uxpB-3p4eA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Vibrio
cholerae) 		5 / 11 VAL A 343
LEU A 261
VAL A 260
ILE A 333
ALA A 184
 None
 1.22A 2zbzA-3p4eA:
undetectable		 2zbzA-3p4eA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Vibrio
cholerae) 		4 / 8 ASN A 193
SER A 246
HIS A 247
ARG A 259
 CIT  A 503 (-3.9A)
None
None
None
 1.07A 3kp2A-3p4eA:
undetectable
3kp2B-3p4eA:
undetectable		 3kp2A-3p4eA:
19.53
3kp2B-3p4eA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Vibrio
cholerae) 		5 / 12 ASP A 108
ASN A  94
ALA A 128
GLY A 126
ILE A 228
 AMP  A 501 (-3.0A)
None
None
None
None
 1.06A 3ku1G-3p4eA:
undetectable		 3ku1G-3p4eA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Vibrio
cholerae) 		4 / 5 LEU A  61
ARG A  36
ILE A 139
PHE A 105
 None
 1.23A 3ln1D-3p4eA:
undetectable		 3ln1D-3p4eA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Vibrio
cholerae) 		5 / 12 VAL A  93
PRO A  53
ILE A 139
VAL A  39
ARG A  36
 None
 1.30A 3p6gA-3p4eA:
undetectable		 3p6gA-3p4eA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)		 3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Vibrio
cholerae) 		6 / 12 LEU A 104
VAL A  60
ILE A 170
GLY A 100
ILE A  97
VAL A 162
 None
 1.50A 3tl9B-3p4eA:
undetectable		 3tl9B-3p4eA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Vibrio
cholerae) 		4 / 4 SER A 187
ASP A  87
ASP A  82
ALA A 224
 None
 1.36A 3uj6A-3p4eA:
undetectable		 3uj6A-3p4eA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Vibrio
cholerae) 		4 / 7 ILE A 248
GLY A 303
SER A 187
PHE A 280
 None
 0.89A 3v7pA-3p4eA:
undetectable		 3v7pA-3p4eA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Vibrio
cholerae) 		4 / 8 ILE A 124
ILE A 127
PHE A 106
GLY A 159
 AMP  A 501 (-4.4A)
None
None
None
 0.80A 4acbC-3p4eA:
undetectable		 4acbC-3p4eA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Vibrio
cholerae) 		4 / 8 GLY A 233
LEU A 236
ILE A 237
ILE A 245
 None
None
None
EDO  A 504 (-4.7A)
 0.76A 4em2A-3p4eA:
undetectable		 4em2A-3p4eA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Vibrio
cholerae) 		4 / 7 LEU A 222
PRO A 190
LEU A  74
TYR A 195
 None
 1.01A 4z4fA-3p4eA:
undetectable		 4z4fA-3p4eA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Vibrio
cholerae) 		4 / 6 THR A 217
GLY A 219
GLU A 220
ILE A  84
 None
 0.81A 5kmfA-3p4eA:
undetectable
5kmfC-3p4eA:
undetectable		 5kmfA-3p4eA:
22.97
5kmfC-3p4eA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Vibrio
cholerae) 		4 / 7 LEU A 222
PRO A 190
LEU A  74
TYR A 195
 None
 0.99A 5t7bA-3p4eA:
undetectable		 5t7bA-3p4eA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Vibrio
cholerae) 		5 / 11 ALA A 315
ASP A 180
VAL A 302
ILE A 305
ILE A 269
 None
 1.08A 5y80A-3p4eA:
undetectable		 5y80A-3p4eA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Vibrio
cholerae) 		3 / 3 ILE A  86
ASN A  94
CYH A 161
 None
 0.92A 6bp4A-3p4eA:
undetectable		 6bp4A-3p4eA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Vibrio
cholerae) 		5 / 12 LEU A  96
GLY A 135
ALA A 134
ILE A  86
VAL A  93
 None
 0.96A 6dh0A-3p4eA:
undetectable		 6dh0A-3p4eA:
14.02