SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3p4g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
3 / 3 LEU A  50
SER A  47
ASN A  64
None
0.79A 1bx4A-3p4gA:
undetectable
1bx4A-3p4gA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
3 / 3 ASP A 177
ASP A 196
ASP A 139
None
None
MG  A 324 ( 2.9A)
0.59A 1eizA-3p4gA:
undetectable
1eizA-3p4gA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
3 / 3 ASP A 177
ASP A 196
ASP A 139
None
None
MG  A 324 ( 2.9A)
0.57A 1ej0A-3p4gA:
undetectable
1ej0A-3p4gA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
4 / 8 GLY A  94
VAL A  65
GLU A  66
ILE A  96
None
0.85A 1pk7B-3p4gA:
undetectable
1pk7B-3p4gA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 ILE A 164
ILE A 221
VAL A 183
ILE A 187
ILE A 231
None
1.23A 1r5lA-3p4gA:
undetectable
1r5lA-3p4gA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 ASP A 122
GLY A 118
ALA A 117
ILE A 143
GLY A 156
CA  A 404 ( 2.4A)
CA  A 404 (-4.1A)
CA  A 405 (-4.7A)
None
CA  A 406 (-4.0A)
0.99A 1sguB-3p4gA:
undetectable
1sguB-3p4gA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_2
(PROTEASE RETROPEPSIN)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 11 LEU A 162
ALA A 136
ASP A 122
VAL A 124
ILE A 143
None
CA  A 406 (-4.5A)
CA  A 404 ( 2.4A)
None
None
0.85A 1t3rB-3p4gA:
undetectable
1t3rB-3p4gA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
3 / 3 HIS A 305
ASP A 259
ASN A 218
None
CA  A 411 ( 2.3A)
None
0.84A 1wg8B-3p4gA:
undetectable
1wg8B-3p4gA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 9 ASN A 188
ILE A 187
ILE A 164
ASP A 167
GLY A 170
MG  A 326 ( 4.1A)
None
None
MG  A 326 (-2.4A)
None
1.09A 2dtjA-3p4gA:
undetectable
2dtjB-3p4gA:
undetectable
2dtjA-3p4gA:
21.95
2dtjB-3p4gA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_1
(POL POLYPROTEIN)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 ASP A 103
GLY A  99
ALA A  98
VAL A 124
GLY A 137
CA  A 403 ( 2.4A)
CA  A 403 (-4.1A)
CA  A 404 (-4.5A)
None
CA  A 405 (-4.1A)
1.02A 2f80A-3p4gA:
undetectable
2f80A-3p4gA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_1
(POL POLYPROTEIN)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 ASP A 103
GLY A  99
ALA A  98
VAL A 124
GLY A 137
CA  A 403 ( 2.4A)
CA  A 403 (-4.1A)
CA  A 404 (-4.5A)
None
CA  A 405 (-4.1A)
0.97A 2f81A-3p4gA:
undetectable
2f81A-3p4gA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_2
(POL POLYPROTEIN)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 ASP A 103
GLY A  99
ALA A  98
VAL A 124
GLY A 137
CA  A 403 ( 2.4A)
CA  A 403 (-4.1A)
CA  A 404 (-4.5A)
None
CA  A 405 (-4.1A)
0.98A 2f81B-3p4gA:
undetectable
2f81B-3p4gA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_1
(POL POLYPROTEIN)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 ASP A 103
GLY A  99
ALA A  98
VAL A 124
GLY A 137
CA  A 403 ( 2.4A)
CA  A 403 (-4.1A)
CA  A 404 (-4.5A)
None
CA  A 405 (-4.1A)
0.98A 2f8gA-3p4gA:
undetectable
2f8gA-3p4gA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
4 / 7 GLY A 198
THR A 197
ASP A 199
ASN A 178
CA  A 409 (-4.2A)
None
None
None
1.09A 2g70A-3p4gA:
undetectable
2g70A-3p4gA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
4 / 7 GLY A 257
THR A 256
ASP A 258
ASN A 237
CA  A 412 (-4.3A)
None
None
None
1.03A 2g70A-3p4gA:
undetectable
2g70A-3p4gA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
4 / 7 GLY A 198
THR A 197
ASP A 199
ASN A 178
CA  A 409 (-4.2A)
None
None
None
1.07A 2g70B-3p4gA:
undetectable
2g70B-3p4gA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
4 / 7 GLY A 257
THR A 256
ASP A 258
ASN A 237
CA  A 412 (-4.3A)
None
None
None
1.00A 2g70B-3p4gA:
undetectable
2g70B-3p4gA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
4 / 6 GLY A 147
TYR A 125
ASP A 148
ASN A 129
None
None
MG  A 325 (-2.4A)
MG  A 325 ( 4.8A)
1.26A 2g72A-3p4gA:
undetectable
2g72A-3p4gA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
4 / 6 TYR A 106
GLY A 109
TYR A 125
ASP A  91
None
1.26A 2g72A-3p4gA:
undetectable
2g72A-3p4gA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
4 / 6 TYR A 106
GLY A 109
TYR A 125
ASP A 110
None
1.27A 2g72A-3p4gA:
undetectable
2g72A-3p4gA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
4 / 7 GLY A  90
TYR A  87
ASP A  91
ASN A  64
None
1.10A 2g72B-3p4gA:
undetectable
2g72B-3p4gA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 ASP A 122
GLY A 118
ALA A 117
ILE A 143
GLY A 156
CA  A 404 ( 2.4A)
CA  A 404 (-4.1A)
CA  A 405 (-4.7A)
None
CA  A 406 (-4.0A)
0.96A 2hs1A-3p4gA:
undetectable
2hs1A-3p4gA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_1
(PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 11 LEU A 162
ALA A 136
ASP A 122
VAL A 124
ILE A 143
None
CA  A 406 (-4.5A)
CA  A 404 ( 2.4A)
None
None
0.86A 2idwA-3p4gA:
undetectable
2idwA-3p4gA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
4 / 4 ASP A 116
ASP A 141
ASP A 133
GLY A 156
None
CA  A 405 ( 2.4A)
None
CA  A 406 (-4.0A)
1.41A 2igtC-3p4gA:
undetectable
2igtC-3p4gA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 10 ILE A 143
ILE A 145
LEU A 153
ASN A 173
VAL A 168
None
1.15A 2nnhB-3p4gA:
undetectable
2nnhB-3p4gA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 LEU A 202
ASP A 160
ILE A 171
VAL A 183
VAL A 181
None
CA  A 406 ( 2.4A)
None
None
None
0.93A 2nnkB-3p4gA:
undetectable
2nnkB-3p4gA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_1
(PROTEASE RETROPEPSIN)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 ASP A 103
GLY A  99
ALA A  98
VAL A 124
GLY A 137
CA  A 403 ( 2.4A)
CA  A 403 (-4.1A)
CA  A 404 (-4.5A)
None
CA  A 405 (-4.1A)
1.01A 2pynA-3p4gA:
undetectable
2pynA-3p4gA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 ASP A 103
GLY A  99
ALA A  98
VAL A 124
GLY A 137
CA  A 403 ( 2.4A)
CA  A 403 (-4.1A)
CA  A 404 (-4.5A)
None
CA  A 405 (-4.1A)
1.01A 2pynB-3p4gA:
undetectable
2pynB-3p4gA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_3
(PROTEASE RETROPEPSIN)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 ASP A 103
GLY A  99
ALA A  98
VAL A 124
GLY A 137
CA  A 403 ( 2.4A)
CA  A 403 (-4.1A)
CA  A 404 (-4.5A)
None
CA  A 405 (-4.1A)
0.97A 2q63B-3p4gA:
undetectable
2q63B-3p4gA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_3
(PROTEASE RETROPEPSIN)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 ASP A 103
GLY A  99
ALA A  98
VAL A 124
GLY A 137
CA  A 403 ( 2.4A)
CA  A 403 (-4.1A)
CA  A 404 (-4.5A)
None
CA  A 405 (-4.1A)
1.00A 2qakB-3p4gA:
undetectable
2qakB-3p4gA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_2
(PROTEASE RETROPEPSIN)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 ASP A 122
GLY A 118
ALA A 117
ILE A 143
GLY A 156
CA  A 404 ( 2.4A)
CA  A 404 (-4.1A)
CA  A 405 (-4.7A)
None
CA  A 406 (-4.0A)
0.94A 2rkgB-3p4gA:
undetectable
2rkgB-3p4gA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_1
(HIV-1 PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 ASP A 103
GLY A  99
ALA A  98
VAL A 124
GLY A 137
CA  A 403 ( 2.4A)
CA  A 403 (-4.1A)
CA  A 404 (-4.5A)
None
CA  A 405 (-4.1A)
1.01A 2z54A-3p4gA:
undetectable
2z54A-3p4gA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
4 / 8 ILE A 164
ASN A 129
SER A 131
SER A 169
None
MG  A 325 ( 4.8A)
None
None
1.11A 2zw9B-3p4gA:
undetectable
2zw9B-3p4gA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_1
(HIV-1 PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 ASP A 103
GLY A  99
ALA A  98
VAL A 124
GLY A 137
CA  A 403 ( 2.4A)
CA  A 403 (-4.1A)
CA  A 404 (-4.5A)
None
CA  A 405 (-4.1A)
1.05A 3d1zA-3p4gA:
undetectable
3d1zA-3p4gA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_2
(HIV-1 PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 ASP A 103
GLY A  99
ALA A  98
VAL A 124
GLY A 137
CA  A 403 ( 2.4A)
CA  A 403 (-4.1A)
CA  A 404 (-4.5A)
None
CA  A 405 (-4.1A)
1.00A 3d1zB-3p4gA:
undetectable
3d1zB-3p4gA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 ASP A 103
GLY A  99
ALA A  98
VAL A 124
GLY A 137
CA  A 403 ( 2.4A)
CA  A 403 (-4.1A)
CA  A 404 (-4.5A)
None
CA  A 405 (-4.1A)
1.02A 3d20A-3p4gA:
undetectable
3d20A-3p4gA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
3 / 3 ASP A 177
ASP A 196
ASP A 139
None
None
MG  A 324 ( 2.9A)
0.65A 3douA-3p4gA:
undetectable
3douA-3p4gA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_2
(PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 11 ASP A 122
GLY A 118
ALA A 117
ILE A 143
GLY A 156
CA  A 404 ( 2.4A)
CA  A 404 (-4.1A)
CA  A 405 (-4.7A)
None
CA  A 406 (-4.0A)
0.98A 3ebzB-3p4gA:
undetectable
3ebzB-3p4gA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 LEU A 153
GLY A 170
ASP A 179
ILE A 221
ASN A 173
None
None
CA  A 407 ( 2.4A)
None
None
1.23A 3eeoA-3p4gA:
undetectable
3eeoA-3p4gA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 THR A 216
GLY A 198
ASN A 178
ASP A 196
GLY A 257
None
CA  A 409 (-4.2A)
None
None
CA  A 412 (-4.3A)
1.16A 3eeyA-3p4gA:
undetectable
3eeyA-3p4gA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 THR A 216
GLY A 198
ASN A 178
ASP A 196
GLY A 257
None
CA  A 409 (-4.2A)
None
None
CA  A 412 (-4.3A)
1.15A 3eeyB-3p4gA:
undetectable
3eeyB-3p4gA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 THR A 216
GLY A 198
ASN A 178
ASP A 196
GLY A 257
None
CA  A 409 (-4.2A)
None
None
CA  A 412 (-4.3A)
1.16A 3eeyC-3p4gA:
undetectable
3eeyC-3p4gA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 THR A 216
GLY A 198
ASN A 178
ASP A 196
GLY A 257
None
CA  A 409 (-4.2A)
None
None
CA  A 412 (-4.3A)
1.16A 3eeyD-3p4gA:
undetectable
3eeyD-3p4gA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 THR A 216
GLY A 198
ASN A 178
ASP A 196
GLY A 257
None
CA  A 409 (-4.2A)
None
None
CA  A 412 (-4.3A)
1.17A 3eeyE-3p4gA:
undetectable
3eeyE-3p4gA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 THR A 216
GLY A 198
ASN A 178
ASP A 196
GLY A 257
None
CA  A 409 (-4.2A)
None
None
CA  A 412 (-4.3A)
1.18A 3eeyH-3p4gA:
undetectable
3eeyH-3p4gA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 THR A 216
GLY A 198
ASN A 178
ASP A 196
GLY A 257
None
CA  A 409 (-4.2A)
None
None
CA  A 412 (-4.3A)
1.17A 3eeyI-3p4gA:
undetectable
3eeyI-3p4gA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 THR A 216
GLY A 198
ASN A 178
ASP A 196
GLY A 257
None
CA  A 409 (-4.2A)
None
None
CA  A 412 (-4.3A)
1.17A 3eeyJ-3p4gA:
undetectable
3eeyJ-3p4gA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 10 LEU A 162
ALA A 136
ASP A 122
VAL A 124
ILE A 143
None
CA  A 406 (-4.5A)
CA  A 404 ( 2.4A)
None
None
0.93A 3ekpB-3p4gA:
undetectable
3ekpB-3p4gA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 9 ASP A 103
GLY A  99
ALA A  98
VAL A 124
GLY A 137
CA  A 403 ( 2.4A)
CA  A 403 (-4.1A)
CA  A 404 (-4.5A)
None
CA  A 405 (-4.1A)
1.01A 3ektA-3p4gA:
undetectable
3ektA-3p4gA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_2
(PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 11 ASP A 103
GLY A  99
ALA A  98
VAL A 124
GLY A 137
CA  A 403 ( 2.4A)
CA  A 403 (-4.1A)
CA  A 404 (-4.5A)
None
CA  A 405 (-4.1A)
1.00A 3ektD-3p4gA:
undetectable
3ektD-3p4gA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 10 LEU A 162
ALA A 136
ASP A 122
VAL A 124
ILE A 143
None
CA  A 406 (-4.5A)
CA  A 404 ( 2.4A)
None
None
0.89A 3em3B-3p4gA:
undetectable
3em3B-3p4gA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_1
(PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 ASP A 103
GLY A  99
ALA A  98
VAL A 124
GLY A 137
CA  A 403 ( 2.4A)
CA  A 403 (-4.1A)
CA  A 404 (-4.5A)
None
CA  A 405 (-4.1A)
0.99A 3gguA-3p4gA:
undetectable
3gguA-3p4gA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 LEU A 282
ARG A 299
VAL A 246
VAL A 263
LEU A 261
None
1.03A 3gwxB-3p4gA:
undetectable
3gwxB-3p4gA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
3 / 3 ARG A 185
ASP A 207
ASP A 167
None
None
MG  A 326 (-2.4A)
0.92A 3jb2A-3p4gA:
undetectable
3jb2A-3p4gA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_2
(HIV-1 PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 ASP A 103
GLY A  99
ALA A  98
VAL A 124
GLY A 137
CA  A 403 ( 2.4A)
CA  A 403 (-4.1A)
CA  A 404 (-4.5A)
None
CA  A 405 (-4.1A)
0.98A 3lzsB-3p4gA:
undetectable
3lzsB-3p4gA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_1
(HIV-1 PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 ASP A 103
GLY A  99
ALA A  98
VAL A 124
GLY A 137
CA  A 403 ( 2.4A)
CA  A 403 (-4.1A)
CA  A 404 (-4.5A)
None
CA  A 405 (-4.1A)
0.98A 3lzuA-3p4gA:
undetectable
3lzuA-3p4gA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_1
(HIV-1 PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 ASP A 103
GLY A  99
ALA A  98
VAL A 124
GLY A 137
CA  A 403 ( 2.4A)
CA  A 403 (-4.1A)
CA  A 404 (-4.5A)
None
CA  A 405 (-4.1A)
0.98A 3mwsA-3p4gA:
undetectable
3mwsA-3p4gA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_1
(PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 ASP A 103
GLY A  99
ALA A  98
VAL A 124
GLY A 137
CA  A 403 ( 2.4A)
CA  A 403 (-4.1A)
CA  A 404 (-4.5A)
None
CA  A 405 (-4.1A)
1.02A 3ndwA-3p4gA:
undetectable
3ndwA-3p4gA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 10 ASP A 103
GLY A  99
ALA A  98
VAL A 124
GLY A 137
CA  A 403 ( 2.4A)
CA  A 403 (-4.1A)
CA  A 404 (-4.5A)
None
CA  A 405 (-4.1A)
0.99A 3oxwA-3p4gA:
undetectable
3oxwA-3p4gA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_2
(HIV-1 PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 10 LEU A 162
ALA A 136
ASP A 122
VAL A 124
ILE A 143
None
CA  A 406 (-4.5A)
CA  A 404 ( 2.4A)
None
None
0.92A 3oxwB-3p4gA:
undetectable
3oxwB-3p4gA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_2
(HIV-1 PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 10 LEU A 162
ALA A 136
ASP A 122
VAL A 124
ILE A 143
None
CA  A 406 (-4.5A)
CA  A 404 ( 2.4A)
None
None
0.97A 3oxwD-3p4gA:
undetectable
3oxwD-3p4gA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_1
(HIV-1 PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 11 LEU A 162
ALA A 136
ASP A 122
VAL A 124
ILE A 143
None
CA  A 406 (-4.5A)
CA  A 404 ( 2.4A)
None
None
0.86A 3oy4A-3p4gA:
undetectable
3oy4A-3p4gA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_1
(PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 ASP A 103
GLY A  99
ALA A  98
VAL A 124
GLY A 137
CA  A 403 ( 2.4A)
CA  A 403 (-4.1A)
CA  A 404 (-4.5A)
None
CA  A 405 (-4.1A)
1.00A 3pwmA-3p4gA:
undetectable
3pwmA-3p4gA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_A_SALA201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 10 ALA A 117
VAL A 115
TYR A 125
ILE A 105
ILE A 145
CA  A 405 (-4.7A)
None
None
None
None
1.32A 3retA-3p4gA:
undetectable
3retB-3p4gA:
undetectable
3retA-3p4gA:
14.95
3retB-3p4gA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 9 ASP A 122
GLY A 118
ALA A 117
ILE A 143
GLY A 156
CA  A 404 ( 2.4A)
CA  A 404 (-4.1A)
CA  A 405 (-4.7A)
None
CA  A 406 (-4.0A)
0.97A 3s53A-3p4gA:
undetectable
3s53A-3p4gA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 9 ASP A 116
THR A 100
THR A 119
GLY A 137
ASP A 135
None
None
None
CA  A 405 (-4.1A)
None
1.05A 3sfuA-3p4gA:
undetectable
3sfuA-3p4gA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_1
(PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 ASP A 103
GLY A  99
ALA A  98
VAL A 124
GLY A 137
CA  A 403 ( 2.4A)
CA  A 403 (-4.1A)
CA  A 404 (-4.5A)
None
CA  A 405 (-4.1A)
0.99A 3tkwA-3p4gA:
undetectable
3tkwA-3p4gA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 9 LEU A  77
ASP A 122
VAL A 115
LEU A 134
ILE A  96
None
CA  A 404 ( 2.4A)
None
None
None
1.02A 3wsjA-3p4gA:
undetectable
3wsjA-3p4gA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 LEU A 162
ALA A 136
ASP A 122
VAL A 124
ILE A 143
None
CA  A 406 (-4.5A)
CA  A 404 ( 2.4A)
None
None
0.90A 4dqbA-3p4gA:
undetectable
4dqbA-3p4gA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_2
(ASPARTYL PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 9 ASP A 103
GLY A  99
ALA A  98
VAL A 124
GLY A 137
CA  A 403 ( 2.4A)
CA  A 403 (-4.1A)
CA  A 404 (-4.5A)
None
CA  A 405 (-4.1A)
1.00A 4dqcB-3p4gA:
undetectable
4dqcB-3p4gA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_1
(ASPARTYL PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 11 LEU A 162
ALA A 136
ASP A 122
VAL A 124
ILE A 143
None
CA  A 406 (-4.5A)
CA  A 404 ( 2.4A)
None
None
0.98A 4dqeA-3p4gA:
undetectable
4dqeA-3p4gA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_1
(ASPARTYL PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 LEU A 162
ALA A 136
ASP A 122
VAL A 124
ILE A 143
None
CA  A 406 (-4.5A)
CA  A 404 ( 2.4A)
None
None
0.94A 4dqfA-3p4gA:
undetectable
4dqfA-3p4gA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_2
(ASPARTYL PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
6 / 10 LEU A 162
ASP A 167
GLY A 191
ILE A 171
VAL A 181
ILE A 164
None
MG  A 326 (-2.4A)
None
None
None
None
1.49A 4dqfB-3p4gA:
undetectable
4dqfB-3p4gA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_1
(WILD-TYPE HIV-1
PROTEASE DIMER)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 11 LEU A 162
ALA A 136
ASP A 122
VAL A 124
ILE A 143
None
CA  A 406 (-4.5A)
CA  A 404 ( 2.4A)
None
None
0.92A 4dqhA-3p4gA:
undetectable
4dqhA-3p4gA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_1
(PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 11 LEU A 162
ALA A 136
ASP A 122
VAL A 124
ILE A 143
None
CA  A 406 (-4.5A)
CA  A 404 ( 2.4A)
None
None
0.96A 4njtA-3p4gA:
undetectable
4njtA-3p4gA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 10 ASP A 103
GLY A  99
ALA A  98
VAL A 124
GLY A 137
CA  A 403 ( 2.4A)
CA  A 403 (-4.1A)
CA  A 404 (-4.5A)
None
CA  A 405 (-4.1A)
1.01A 4njtB-3p4gA:
undetectable
4njtB-3p4gA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_1
(PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 11 LEU A 162
ALA A 136
ASP A 122
ILE A 105
ILE A 143
None
CA  A 406 (-4.5A)
CA  A 404 ( 2.4A)
None
None
0.95A 4njtC-3p4gA:
undetectable
4njtC-3p4gA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_1
(PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 11 LEU A 162
ALA A 136
ASP A 122
VAL A 124
ILE A 143
None
CA  A 406 (-4.5A)
CA  A 404 ( 2.4A)
None
None
0.93A 4njtC-3p4gA:
undetectable
4njtC-3p4gA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_1
(PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 ASP A 103
GLY A  99
ALA A  98
VAL A 124
GLY A 137
CA  A 403 ( 2.4A)
CA  A 403 (-4.1A)
CA  A 404 (-4.5A)
None
CA  A 405 (-4.1A)
0.98A 4njvA-3p4gA:
undetectable
4njvA-3p4gA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 ASP A 103
GLY A  99
ALA A  98
VAL A 124
GLY A 137
CA  A 403 ( 2.4A)
CA  A 403 (-4.1A)
CA  A 404 (-4.5A)
None
CA  A 405 (-4.1A)
1.02A 4njvD-3p4gA:
undetectable
4njvD-3p4gA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 10 LEU A 208
VAL A 240
LEU A 261
LEU A 254
VAL A 271
None
1.21A 4po0A-3p4gA:
undetectable
4po0A-3p4gA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_1
(ASPARTYL PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 10 ASP A 122
GLY A 118
ALA A 117
ILE A 143
GLY A 156
CA  A 404 ( 2.4A)
CA  A 404 (-4.1A)
CA  A 405 (-4.7A)
None
CA  A 406 (-4.0A)
0.94A 4q1yA-3p4gA:
undetectable
4q1yA-3p4gA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_1
(HIV-1 PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 11 LEU A 162
ALA A 136
ASP A 122
VAL A 124
ILE A 143
None
CA  A 406 (-4.5A)
CA  A 404 ( 2.4A)
None
None
0.94A 4rvjA-3p4gA:
undetectable
4rvjA-3p4gA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_1
(HIV-1 PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 11 LEU A 162
ALA A 136
ASP A 122
VAL A 124
ILE A 143
None
CA  A 406 (-4.5A)
CA  A 404 ( 2.4A)
None
None
0.95A 4rvjC-3p4gA:
undetectable
4rvjC-3p4gA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
3 / 3 ASP A 139
GLY A 158
ASP A 160
MG  A 324 ( 2.9A)
CA  A 407 (-4.2A)
CA  A 406 ( 2.4A)
0.53A 4xdtA-3p4gA:
undetectable
4xdtA-3p4gA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
3 / 3 ASP A 177
GLY A 198
ASP A 200
None
CA  A 409 (-4.2A)
CA  A 408 ( 2.4A)
0.56A 4xdtA-3p4gA:
undetectable
4xdtA-3p4gA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
4 / 6 ASP A 219
GLY A 214
ASP A 213
ASP A 200
CA  A 409 ( 2.4A)
CA  A 409 (-4.5A)
None
CA  A 408 ( 2.4A)
1.24A 5hp1A-3p4gA:
undetectable
5hp1A-3p4gA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
4 / 8 TYR A 285
VAL A 263
TYR A 290
ILE A 306
None
0.92A 5mzrE-3p4gA:
undetectable
5mzrE-3p4gA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
6 / 11 LEU A 195
GLY A 215
GLY A 234
SER A 201
LEU A 202
VAL A 240
None
CA  A 409 (-4.1A)
CA  A 410 (-4.0A)
None
None
None
1.44A 5o96G-3p4gA:
undetectable
5o96G-3p4gA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_1
(PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 ASP A 103
GLY A  99
ALA A  98
VAL A 124
GLY A 137
CA  A 403 ( 2.4A)
CA  A 403 (-4.1A)
CA  A 404 (-4.5A)
None
CA  A 405 (-4.1A)
0.98A 5t2zA-3p4gA:
undetectable
5t2zA-3p4gA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
4 / 7 GLY A 210
GLN A 245
ASP A 207
ASP A 167
None
None
None
MG  A 326 (-2.4A)
1.13A 5vlmE-3p4gA:
undetectable
5vlmE-3p4gA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
4 / 8 VAL A 212
ASP A 213
GLY A 255
LEU A 254
None
None
CA  A 411 (-4.0A)
None
0.82A 5w3jB-3p4gA:
undetectable
5w3jB-3p4gA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 GLY A 118
GLY A  80
ASP A 122
ASN A 121
ASP A 160
CA  A 404 (-4.1A)
CA  A 402 (-4.0A)
CA  A 404 ( 2.4A)
MG  A 324 ( 4.6A)
CA  A 406 ( 2.4A)
1.25A 5yniA-3p4gA:
undetectable
5yniA-3p4gA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 GLY A 215
GLY A 175
ASP A 219
ASN A 218
ASP A 259
CA  A 409 (-4.1A)
CA  A 407 (-4.1A)
CA  A 409 ( 2.4A)
None
CA  A 411 ( 2.3A)
1.29A 5yniA-3p4gA:
undetectable
5yniA-3p4gA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 GLY A 118
GLY A  80
ASP A 122
ASN A 121
ASP A 160
CA  A 404 (-4.1A)
CA  A 402 (-4.0A)
CA  A 404 ( 2.4A)
MG  A 324 ( 4.6A)
CA  A 406 ( 2.4A)
1.27A 5ynmA-3p4gA:
undetectable
5ynmA-3p4gA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 GLY A 137
GLY A  99
ASP A 141
ASN A 140
ASP A 179
CA  A 405 (-4.1A)
CA  A 403 (-4.1A)
CA  A 405 ( 2.4A)
None
CA  A 407 ( 2.4A)
1.33A 5ynmA-3p4gA:
undetectable
5ynmA-3p4gA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 GLY A 215
GLY A 175
ASP A 219
ASN A 218
ASP A 259
CA  A 409 (-4.1A)
CA  A 407 (-4.1A)
CA  A 409 ( 2.4A)
None
CA  A 411 ( 2.3A)
1.31A 5ynmA-3p4gA:
undetectable
5ynmA-3p4gA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 10 GLY A 269
LEU A 267
VAL A 240
VAL A 227
LEU A 261
None
1.08A 6czmA-3p4gA:
undetectable
6czmC-3p4gA:
undetectable
6czmA-3p4gA:
20.54
6czmC-3p4gA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_1
(PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 LEU A  77
VAL A 115
GLY A 109
LEU A 134
ILE A  96
None
1.01A 6dgxB-3p4gA:
undetectable
6dgxB-3p4gA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_1
(PROTEASE)
3p4g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis)
5 / 12 LEU A  77
VAL A 115
GLY A 109
LEU A 134
ILE A  96
None
1.03A 6dh6B-3p4gA:
undetectable
6dh6B-3p4gA:
13.29