SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3p4s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 8 GLY A  16
GLY A  13
HIS A 510
VAL A 157
 None
FAD  A 601 (-3.2A)
None
FAD  A 601 (-4.1A)
 0.88A 1dbbH-3p4sA:
undetectable
1dbbL-3p4sA:
undetectable		 1dbbH-3p4sA:
16.72
1dbbL-3p4sA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		6 / 12 ILE A 160
VAL A 157
VAL A 189
ALA A 191
ILE A   9
ILE A  32
 None
FAD  A 601 (-4.1A)
None
None
None
None
 1.47A 1epbB-3p4sA:
undetectable		 1epbB-3p4sA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 4 ILE A 331
LEU A 254
VAL A 350
ILE A 348
 None
 0.77A 1fm6D-3p4sA:
undetectable		 1fm6D-3p4sA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 8 LEU A 374
VAL A 188
ASP A 159
VAL A 157
 None
None
None
FAD  A 601 (-4.1A)
 0.92A 1iwiA-3p4sA:
undetectable		 1iwiA-3p4sA:
22.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KF6_A_ACTA703_0
(FUMARATE REDUCTASE
FLAVOPROTEIN)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 4 PHE A 554
ASP A 556
ARG A 562
GLU A 564
 None
 0.50A 1kf6A-3p4sA:
68.6		 1kf6A-3p4sA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		3 / 3 ARG A 529
ILE A 570
TRP A  75
 None
 0.97A 1nodB-3p4sA:
undetectable		 1nodB-3p4sA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		3 / 3 ARG A 105
VAL A 113
TRP A 125
 None
 1.25A 1qw6A-3p4sA:
undetectable		 1qw6A-3p4sA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		3 / 3 ARG A 105
VAL A 113
TRP A 125
 None
 1.29A 1vagA-3p4sA:
undetectable		 1vagA-3p4sA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 6 VAL A 339
THR A 353
SER A 239
PRO A 237
 None
 1.11A 2hdnJ-3p4sA:
undetectable
2hdnK-3p4sA:
undetectable
2hdnL-3p4sA:
undetectable		 2hdnJ-3p4sA:
21.45
2hdnK-3p4sA:
7.10
2hdnL-3p4sA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		3 / 3 ARG A 529
ILE A 570
TRP A  75
 None
 1.01A 2nodB-3p4sA:
undetectable		 2nodB-3p4sA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 5 ALA A  26
ALA A 414
ALA A 187
VAL A 189
 None
 0.92A 2nyrB-3p4sA:
undetectable		 2nyrB-3p4sA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 12 ILE A  32
GLY A  16
ARG A 404
ALA A  22
ALA A  23
 None
 0.99A 2oc8A-3p4sA:
undetectable		 2oc8A-3p4sA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 12 GLY A 456
GLY A 464
GLY A 462
GLU A 461
ILE A 465
 None
 0.83A 2oxtB-3p4sA:
undetectable		 2oxtB-3p4sA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 12 GLY A  50
GLY A  51
MET A 135
ALA A 397
GLY A 117
 FAD  A 601 (-3.3A)
FAD  A 601 (-4.5A)
None
None
None
 0.95A 2pkkA-3p4sA:
3.6		 2pkkA-3p4sA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 11 LEU A 170
ALA A  33
ALA A   8
LEU A 374
GLN A   4
 None
 1.26A 3bszE-3p4sA:
undetectable		 3bszE-3p4sA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 6 ARG A 184
GLY A 420
GLU A 426
GLU A 422
 None
 0.94A 3k9fA-3p4sA:
undetectable
3k9fB-3p4sA:
undetectable
3k9fD-3p4sA:
undetectable		 3k9fA-3p4sA:
21.78
3k9fB-3p4sA:
21.78
3k9fD-3p4sA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 8 ASN A 204
THR A 203
LEU A 242
ALA A  47
 FAD  A 601 ( 4.7A)
FAD  A 601 (-4.7A)
FAD  A 601 (-3.6A)
FAD  A 601 ( 4.1A)
 0.95A 3kp6A-3p4sA:
undetectable		 3kp6A-3p4sA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 4 LEU A  17
GLY A  16
GLY A  13
THR A  45
 None
None
FAD  A 601 (-3.2A)
FAD  A 601 (-2.9A)
 0.95A 3si7A-3p4sA:
undetectable		 3si7A-3p4sA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 4 LEU A 508
GLY A 509
GLY A 511
THR A 209
 None
 0.91A 3si7A-3p4sA:
undetectable		 3si7A-3p4sA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 12 GLN A 230
GLY A 530
ASP A 288
GLU A 227
ALA A 388
 None
 1.23A 3t7sA-3p4sA:
2.1		 3t7sA-3p4sA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		3 / 3 ARG A 114
GLU A 245
THR A 244
 None
3NP  A 602 (-4.5A)
3NP  A 602 (-4.5A)
 0.84A 3v4tA-3p4sA:
undetectable		 3v4tA-3p4sA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_A_T3A1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 12 ARG A 115
PHE A 116
GLY A 118
ARG A 114
GLU A 122
 None
3NP  A 602 (-4.7A)
None
None
None
 1.29A 4bvaA-3p4sA:
3.0		 4bvaA-3p4sA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_B_T3B1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 12 ARG A 115
PHE A 116
GLY A 118
ARG A 114
GLU A 122
 None
3NP  A 602 (-4.7A)
None
None
None
 1.39A 4bvaB-3p4sA:
2.8		 4bvaB-3p4sA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 3p4s FUMARATE REDUCTASE
SUBUNIT D
(Escherichia
coli) 		5 / 12 GLY D  18
ALA D  19
GLY D  21
GLY D  20
LEU D  73
 None
 0.92A 4o3fA-3p4sD:
undetectable		 4o3fA-3p4sD:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 12 TYR A 199
GLY A 196
LEU A 512
LEU A 482
ALA A 458
 None
 1.04A 4wcxC-3p4sA:
4.9		 4wcxC-3p4sA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 6 SER A 382
GLY A 530
ASP A  74
ARG A 529
 None
 0.91A 5cdnR-3p4sA:
2.0
5cdnS-3p4sA:
undetectable		 5cdnR-3p4sA:
23.77
5cdnS-3p4sA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 8 GLU A 461
LEU A 471
MET A 472
LEU A 535
 None
 1.26A 5dxeA-3p4sA:
undetectable		 5dxeA-3p4sA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 7 VAL A 229
THR A 357
MET A 213
VAL A 514
 None
 0.95A 5e4dA-3p4sA:
undetectable
5e4dB-3p4sA:
undetectable		 5e4dA-3p4sA:
15.81
5e4dB-3p4sA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 8 TYR A 356
LEU A 399
LEU A 396
THR A 124
 FAD  A 601 (-4.4A)
FAD  A 601 (-4.1A)
FAD  A 601 (-3.8A)
None
 1.03A 5hs6A-3p4sA:
undetectable		 5hs6A-3p4sA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 5 HIS A 137
VAL A  38
GLY A  13
ALA A  12
 None
FAD  A 601 (-3.9A)
FAD  A 601 (-3.2A)
FAD  A 601 (-3.4A)
 1.04A 5hwaA-3p4sA:
undetectable		 5hwaA-3p4sA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		3 / 3 ARG A 390
HIS A 232
ARG A 287
 FAD  A 601 ( 3.2A)
3NP  A 602 (-4.7A)
3NP  A 602 (-1.4A)
 1.10A 5iaoC-3p4sA:
undetectable		 5iaoC-3p4sA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		3 / 3 ARG A 390
HIS A 232
ARG A 287
 FAD  A 601 ( 3.2A)
3NP  A 602 (-4.7A)
3NP  A 602 (-1.4A)
 1.16A 5iaoF-3p4sA:
undetectable		 5iaoF-3p4sA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		3 / 3 VAL A  86
HIS A  67
VAL A  70
 None
 0.67A 5jmnC-3p4sA:
2.3		 5jmnC-3p4sA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		3 / 3 VAL A 171
GLU A 422
GLU A 426
 None
 0.77A 5jsdB-3p4sA:
undetectable
5jsdC-3p4sA:
undetectable		 5jsdB-3p4sA:
21.73
5jsdC-3p4sA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		3 / 3 VAL A 111
SER A 104
TRP A 103
 None
 1.00A 5jwaA-3p4sA:
10.1		 5jwaA-3p4sA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 6 GLU A 250
ARG A 327
ARG A 114
ARG A 115
 None
 1.20A 5l6eA-3p4sA:
undetectable
5l6eB-3p4sA:
undetectable		 5l6eA-3p4sA:
19.16
5l6eB-3p4sA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 4 GLY A 511
ALA A 195
MET A 459
THR A 357
 None
 0.99A 5n0sB-3p4sA:
undetectable		 5n0sB-3p4sA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		3 / 3 THR A 234
PRO A 343
ARG A 317
 None
 0.46A 5nd7B-3p4sA:
undetectable		 5nd7B-3p4sA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 6 ARG A 390
ALA A 397
LEU A 399
SER A  52
 FAD  A 601 ( 3.2A)
None
FAD  A 601 (-4.1A)
None
 1.12A 5phhA-3p4sA:
undetectable		 5phhA-3p4sA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 4 LEU A 385
GLY A 384
SER A 382
SER A 381
 None
 1.32A 5uunA-3p4sA:
2.6		 5uunA-3p4sA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 4 LEU A 385
GLY A 384
SER A 382
SER A 381
 None
 1.35A 5uunB-3p4sA:
undetectable		 5uunB-3p4sA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 8 ALA A 195
VAL A 208
THR A 203
GLY A 193
 None
None
FAD  A 601 (-4.7A)
FAD  A 601 (-3.3A)
 1.00A 5v0vA-3p4sA:
undetectable		 5v0vA-3p4sA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		3 / 3 ASP A 364
PHE A 375
ARG A 413
 None
 1.04A 5yw0A-3p4sA:
undetectable		 5yw0A-3p4sA:
19.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		3 / 3 TYR A  84
ASN A 366
LEU A 405
 None
 0.33A 6b58A-3p4sA:
63.5		 6b58A-3p4sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B58_A_ACTA606_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 5 PHE A  66
ASP A  83
HIS A  87
THR A 571
 None
 1.32A 6b58A-3p4sA:
63.5		 6b58A-3p4sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B58_A_ACTA606_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 5 PHE A  66
ASP A  83
HIS A  87
THR A 572
 None
 0.39A 6b58A-3p4sA:
63.5		 6b58A-3p4sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		3 / 3 HIS A 232
HIS A 355
ARG A 390
 3NP  A 602 (-4.7A)
FAD  A 601 (-4.3A)
FAD  A 601 ( 3.2A)
 0.60A 6b58A-3p4sA:
63.5		 6b58A-3p4sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B58_C_ACTC608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 5 TYR A 266
LYS A 289
GLN A 292
HIS A 296
TYR A 466
 None
 0.71A 6b58C-3p4sA:
63.6		 6b58C-3p4sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B58_C_ACTC609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 5 PHE A  62
PHE A  66
ASP A  83
HIS A  87
 None
 0.28A 6b58C-3p4sA:
63.6		 6b58C-3p4sA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_I_EY4I500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 5 GLN A  57
VAL A  55
TRP A 125
THR A  91
 None
 1.42A 6cduI-3p4sA:
4.7
6cduJ-3p4sA:
4.7		 6cduI-3p4sA:
19.06
6cduJ-3p4sA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA806_0
(GEPHYRIN)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 4 MET A 213
GLY A 214
HIS A 510
GLY A 210
 None
 1.28A 6fgdA-3p4sA:
2.7		 6fgdA-3p4sA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 4 HIS A  44
LEU A 334
TYR A 338
GLY A 240
 FAD  A 601 (-3.7A)
None
None
None
 1.49A 6n91A-3p4sA:
undetectable		 6n91A-3p4sA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_1
(ADENOSINE DEAMINASE)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 4 HIS A  44
LEU A 334
TYR A 338
GLY A 240
 FAD  A 601 (-3.7A)
None
None
None
 1.48A 6n91B-3p4sA:
undetectable		 6n91B-3p4sA:
9.19