SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3p4x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3p4x REVERSE GYRASE
HELICASE-LIKE DOMAIN
(Thermotoga
maritima) 		4 / 7 ILE A 229
PHE A 270
LEU A 274
ASP A 216
 None
 0.98A 1yc2E-3p4xA:
undetectable		 1yc2E-3p4xA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 3p4x REVERSE GYRASE
HELICASE-LIKE DOMAIN
(Thermotoga
maritima) 		4 / 7 ALA A 468
GLY A 470
ARG A 286
PHE A 308
 None
 0.77A 2wq5A-3p4xA:
undetectable		 2wq5A-3p4xA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 3p4x REVERSE GYRASE
HELICASE-LIKE DOMAIN
(Thermotoga
maritima) 		4 / 4 GLY A 322
VAL A 361
GLY A 385
THR A 386
 None
 0.85A 3ib2A-3p4xA:
undetectable		 3ib2A-3p4xA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 3p4x REVERSE GYRASE
HELICASE-LIKE DOMAIN
(Thermotoga
maritima) 		5 / 12 LEU A 269
LEU A 268
ILE A 229
ILE A 228
LEU A 274
 None
 1.22A 4j24B-3p4xA:
undetectable		 4j24B-3p4xA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 3p4x REVERSE GYRASE
HELICASE-LIKE DOMAIN
(Thermotoga
maritima) 		3 / 3 VAL A 284
ARG A 263
PRO A 267
 None
 0.80A 5koxA-3p4xA:
undetectable		 5koxA-3p4xA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 3p4x REVERSE GYRASE
HELICASE-LIKE DOMAIN
(Thermotoga
maritima) 		5 / 12 ALA A 316
LYS A 300
GLU A 303
LEU A 305
GLU A 306
 None
 1.19A 5nwuA-3p4xA:
undetectable		 5nwuA-3p4xA:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 3p4x REVERSE GYRASE
HELICASE-LIKE DOMAIN
(Thermotoga
maritima) 		5 / 12 PHE A 109
PHE A 199
VAL A  91
PHE A  67
VAL A 254
 None
 1.23A 6ap6A-3p4xA:
undetectable		 6ap6A-3p4xA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 3p4x REVERSE GYRASE
HELICASE-LIKE DOMAIN
(Thermotoga
maritima) 		5 / 12 PHE A 109
PHE A 199
VAL A  91
PHE A  67
VAL A 254
 None
 1.24A 6ap6B-3p4xA:
undetectable		 6ap6B-3p4xA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		 3p4x REVERSE GYRASE
HELICASE-LIKE DOMAIN
(Thermotoga
maritima) 		5 / 11 ILE A  90
THR A  80
THR A 108
LEU A 115
PHE A  71
 None
ADP  A 800 (-4.2A)
ADP  A 800 (-3.4A)
None
ADP  A 800 (-4.6A)
 1.31A 6hupA-3p4xA:
undetectable
6hupB-3p4xA:
undetectable		 6hupA-3p4xA:
11.89
6hupB-3p4xA:
11.23