SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3p56'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 3p56 RIBONUCLEASE H2
SUBUNIT A
(Homo
sapiens) 		5 / 11 LEU A 153
VAL A  33
VAL A 138
GLY A  32
TYR A 149
 None
 1.29A 1fkpA-3p56A:
2.8		 1fkpA-3p56A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 3p56 RIBONUCLEASE H2
SUBUNIT A
(Homo
sapiens) 		5 / 12 ALA A  48
GLY A  37
LEU A  16
ALA A 189
LEU A  93
 None
 1.42A 1jipA-3p56A:
undetectable		 1jipA-3p56A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 3p56 RIBONUCLEASE H2
SUBUNIT A
(Homo
sapiens) 		4 / 8 LEU A 153
VAL A  33
GLY A  32
TYR A 149
 None
 0.98A 1jlfA-3p56A:
3.6
1jlfB-3p56A:
4.3		 1jlfA-3p56A:
20.60
1jlfB-3p56A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3p56 RIBONUCLEASE H2
SUBUNIT A
(Homo
sapiens) 		5 / 10 LEU A 153
VAL A  33
VAL A 138
GLY A  32
TYR A 149
 None
 1.28A 1lw0A-3p56A:
3.1		 1lw0A-3p56A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3p56 RIBONUCLEASE H2
SUBUNIT A
(Homo
sapiens) 		3 / 3 LYS A  64
TYR A 172
PRO A 173
 None
 1.44A 2j9cC-3p56A:
undetectable		 2j9cC-3p56A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3p56 RIBONUCLEASE H2
SUBUNIT A
(Homo
sapiens) 		5 / 12 LEU A 100
THR A 120
ASP A 119
SER A 156
TYR A 111
 None
 1.36A 2y00B-3p56A:
undetectable		 2y00B-3p56A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)		 3p56 RIBONUCLEASE H2
SUBUNIT A
(Homo
sapiens) 		5 / 10 LEU A 153
VAL A  33
VAL A 138
GLY A  32
TYR A 149
 None
 1.27A 3qipA-3p56A:
3.6		 3qipA-3p56A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 3p56 RIBONUCLEASE H2
SUBUNIT A
(Homo
sapiens) 		4 / 8 VAL A 135
TYR A 127
ILE A 125
GLN A 126
 None
 1.00A 3remA-3p56A:
undetectable		 3remA-3p56A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 3p56 RIBONUCLEASE H2
SUBUNIT A
(Homo
sapiens) 		4 / 8 VAL A 135
TYR A 127
ILE A 125
GLN A 126
 None
 0.98A 3remB-3p56A:
undetectable		 3remB-3p56A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_D_ZMRD1002_2
(NEURAMINIDASE)		 3p56 RIBONUCLEASE H2
SUBUNIT A
(Homo
sapiens) 		4 / 5 LEU A 220
ARG A 235
TRP A 238
ILE A 101
 None
 1.45A 3ticD-3p56A:
undetectable		 3ticD-3p56A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 3p56 RIBONUCLEASE H2
SUBUNIT A
(Homo
sapiens) 		3 / 3 ASN A 112
SER A 115
ARG A 152
 None
 0.70A 5b2qA-3p56A:
2.9		 5b2qA-3p56A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 3p56 RIBONUCLEASE H2
SUBUNIT A
(Homo
sapiens) 		4 / 6 ARG A  13
GLY A  12
SER A  97
LEU A  96
 None
 0.86A 5bphA-3p56A:
undetectable		 5bphA-3p56A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3p56 RIBONUCLEASE H2
SUBUNIT A
(Homo
sapiens) 		5 / 11 LEU A 153
VAL A  33
VAL A 138
GLY A  32
TYR A 149
 None
 1.31A 5hbmA-3p56A:
3.7		 5hbmA-3p56A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 3p56 RIBONUCLEASE H2
SUBUNIT A
(Homo
sapiens) 		3 / 3 HIS A 223
GLU A 222
TRP A 219
 None
 0.81A 5odiD-3p56A:
undetectable		 5odiD-3p56A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 3p56 RIBONUCLEASE H2
SUBUNIT A
(Homo
sapiens) 		3 / 3 HIS A 223
GLU A 222
TRP A 219
 None
 0.76A 5odqD-3p56A:
undetectable		 5odqD-3p56A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 3p56 RIBONUCLEASE H2
SUBUNIT A
(Homo
sapiens) 		3 / 3 HIS A 223
GLU A 222
TRP A 219
 None
 0.76A 5odrD-3p56A:
undetectable		 5odrD-3p56A:
18.58