SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3p5b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_N_TRPN81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3p5b PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens) 		5 / 10 GLY P 117
HIS P 116
THR P  86
HIS P  87
SER P  91
 None
 1.46A 1utdN-3p5bP:
undetectable
1utdO-3p5bP:
undetectable		 1utdN-3p5bP:
19.57
1utdO-3p5bP:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 3p5b LOW DENSITY
LIPOPROTEIN RECEPTOR
VARIANT
(Homo
sapiens) 		5 / 12 ASN L 570
GLY L 552
ILE L 545
SER L 566
VAL L 569
 None
 1.09A 3nk7A-3p5bL:
undetectable		 3nk7A-3p5bL:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3p5b LOW DENSITY
LIPOPROTEIN RECEPTOR
VARIANT
(Homo
sapiens) 		3 / 3 TYR L 511
MET L 510
ILE L 467
 None
 0.92A 4c8bB-3p5bL:
undetectable		 4c8bB-3p5bL:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3p5b LOW DENSITY
LIPOPROTEIN RECEPTOR
VARIANT
(Homo
sapiens) 		3 / 3 ASP L 461
VAL L 415
ASN L 644
 None
 0.70A 4lmnA-3p5bL:
undetectable		 4lmnA-3p5bL:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 3p5b LOW DENSITY
LIPOPROTEIN RECEPTOR
VARIANT
(Homo
sapiens) 		4 / 5 LEU L 590
ALA L 500
THR L 513
ILE L 521
 None
 0.97A 4xe3A-3p5bL:
undetectable		 4xe3A-3p5bL:
21.23