SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3p5m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 3p5m ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		5 / 11 ALA A  99
LEU A 108
ILE A 170
ILE A 144
ILE A 159
 None
 1.06A 1dyrA-3p5mA:
undetectable		 1dyrA-3p5mA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)		 3p5m ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		5 / 7 ALA A 136
GLY A 135
GLY A 134
ASN A  78
PHE A 125
 None
 1.11A 2c49B-3p5mA:
undetectable		 2c49B-3p5mA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3p5m ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		3 / 3 SER A  46
HIS A  37
ASP A  18
 None
 0.83A 2oxtA-3p5mA:
undetectable		 2oxtA-3p5mA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3p5m ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		4 / 7 ALA A 107
ALA A 109
THR A  85
LEU A 213
 None
 0.93A 2wx2A-3p5mA:
undetectable		 2wx2A-3p5mA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3p5m ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		4 / 8 ALA A 107
ALA A 109
THR A  85
LEU A 210
 None
 0.96A 2wx2B-3p5mA:
undetectable		 2wx2B-3p5mA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3p5m ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		4 / 8 ALA A 107
ALA A 109
THR A  85
LEU A 213
 None
 1.02A 2wx2B-3p5mA:
undetectable		 2wx2B-3p5mA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 3p5m ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		4 / 8 ALA A 107
ALA A 109
THR A  85
LEU A 210
 None
 0.92A 3khmA-3p5mA:
undetectable		 3khmA-3p5mA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 3p5m ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		4 / 8 ALA A 107
ALA A 109
THR A  85
LEU A 213
 None
 0.94A 3khmA-3p5mA:
undetectable		 3khmA-3p5mA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 3p5m ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		4 / 8 ALA A 107
ALA A 109
THR A  85
LEU A 213
 None
 0.97A 3l4dA-3p5mA:
undetectable		 3l4dA-3p5mA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 3p5m ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		4 / 8 ALA A 107
ALA A 109
THR A  85
LEU A 210
 None
 1.06A 3l4dD-3p5mA:
undetectable		 3l4dD-3p5mA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 3p5m ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		4 / 8 ALA A 107
ALA A 109
THR A  85
LEU A 213
 None
 0.98A 3l4dD-3p5mA:
undetectable		 3l4dD-3p5mA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 3p5m ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		4 / 6 ALA A 136
ALA A 153
LEU A 140
THR A 149
 None
 1.00A 4dtzB-3p5mA:
undetectable		 4dtzB-3p5mA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 3p5m ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		3 / 3 LEU A 205
LYS A 202
THR A 201
 None
 0.61A 4lj0A-3p5mA:
undetectable		 4lj0A-3p5mA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 3p5m ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		5 / 12 LEU A  52
GLY A 103
GLY A  62
ASN A  24
CYH A 110
 None
 1.33A 4x61A-3p5mA:
undetectable		 4x61A-3p5mA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H1E_A_VDXA501_1
(VITAMIN D3 RECEPTOR)		 3p5m ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		5 / 12 PHE A  59
LEU A  52
ILE A  38
VAL A   6
HIS A   8
 None
None
None
EDO  A 252 (-4.3A)
None
 1.41A 5h1eA-3p5mA:
undetectable		 5h1eA-3p5mA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3p5m ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		5 / 12 GLY A 145
SER A 160
ILE A 159
PHE A 121
MET A 152
 None
 1.13A 5igyA-3p5mA:
undetectable		 5igyA-3p5mA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3p5m ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		5 / 12 GLY A 145
SER A 160
ILE A 159
PHE A 121
MET A 152
 None
 1.02A 5ih0A-3p5mA:
undetectable		 5ih0A-3p5mA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 3p5m ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		4 / 6 ARG A  57
ALA A  58
TYR A 120
SER A  61
 None
 1.16A 5phhA-3p5mA:
undetectable		 5phhA-3p5mA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 3p5m ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		5 / 10 ILE A 219
ASP A 133
GLY A 134
ASN A  78
MET A 131
 None
 1.31A 5x66D-3p5mA:
undetectable		 5x66D-3p5mA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3p5m ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		5 / 10 PHE A 121
GLY A 103
ILE A  84
ALA A 109
LEU A 108
 None
 1.44A 5zjiA-3p5mA:
undetectable
5zjiJ-3p5mA:
undetectable		 5zjiA-3p5mA:
12.75
5zjiJ-3p5mA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 3p5m ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		5 / 12 PHE A 233
GLY A  62
VAL A 100
THR A 126
GLY A 129
 None
 1.18A 6brdB-3p5mA:
undetectable		 6brdB-3p5mA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 3p5m ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		5 / 11 PHE A 121
SER A 119
ALA A 115
THR A  53
LEU A  52
 None
 1.44A 6efnA-3p5mA:
2.3		 6efnA-3p5mA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 3p5m ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		5 / 10 LEU A 225
ASP A 133
GLY A 134
ASN A  78
MET A 131
 None
 1.35A 6r2eC-3p5mA:
undetectable		 6r2eC-3p5mA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 3p5m ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		5 / 10 LEU A 225
ASP A 133
GLY A 134
ASN A  78
MET A 131
 None
 1.43A 6r2eD-3p5mA:
undetectable		 6r2eD-3p5mA:
21.10