SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3p5n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3p5n RIBOFLAVIN UPTAKE
PROTEIN
(Staphylococcus
aureus) 		5 / 10 LEU A  96
LEU A 116
ALA A 119
PHE A  46
ILE A 171
 None
 1.20A 1g5yC-3p5nA:
2.9		 1g5yC-3p5nA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 3p5n RIBOFLAVIN UPTAKE
PROTEIN
(Staphylococcus
aureus) 		4 / 6 LEU A  52
ALA A  99
LEU A  96
THR A  98
 None
 1.18A 1tyrA-3p5nA:
undetectable		 1tyrA-3p5nA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 3p5n RIBOFLAVIN UPTAKE
PROTEIN
(Staphylococcus
aureus) 		4 / 7 PHE A  95
TYR A 103
TYR A 100
THR A  55
 None
 1.49A 2q6kA-3p5nA:
undetectable		 2q6kA-3p5nA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3p5n RIBOFLAVIN UPTAKE
PROTEIN
(Staphylococcus
aureus) 		4 / 4 PHE A  26
TYR A  75
ILE A  18
LEU A  21
 None
 1.01A 3sudA-3p5nA:
undetectable		 3sudA-3p5nA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 3p5n RIBOFLAVIN UPTAKE
PROTEIN
(Staphylococcus
aureus) 		4 / 8 ILE A 113
LYS A 167
ILE A 173
PHE A 175
 None
RBF  A 190 (-3.2A)
None
None
 0.98A 4hdlA-3p5nA:
undetectable		 4hdlA-3p5nA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 3p5n RIBOFLAVIN UPTAKE
PROTEIN
(Staphylococcus
aureus) 		5 / 9 ALA A  99
PHE A  95
ILE A 173
VAL A 174
VAL A  49
 None
 1.32A 4r20B-3p5nA:
undetectable		 4r20B-3p5nA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 3p5n RIBOFLAVIN UPTAKE
PROTEIN
(Staphylococcus
aureus) 		4 / 4 VAL A 134
ILE A 129
ASN A 164
VAL A 157
 None
None
RBF  A 190 (-3.3A)
None
 1.03A 5ajqA-3p5nA:
undetectable		 5ajqA-3p5nA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 3p5n RIBOFLAVIN UPTAKE
PROTEIN
(Staphylococcus
aureus) 		3 / 3 PRO A  50
ILE A  35
SER A  22
 None
 0.78A 5fsaA-3p5nA:
1.4		 5fsaA-3p5nA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 3p5n RIBOFLAVIN UPTAKE
PROTEIN
(Staphylococcus
aureus) 		3 / 3 PRO A  50
ILE A 166
SER A  22
 None
 0.61A 5fsaA-3p5nA:
1.4		 5fsaA-3p5nA:
17.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3p5n RIBOFLAVIN UPTAKE
PROTEIN
(Staphylococcus
aureus) 		7 / 12 LEU A  42
ASP A  81
GLY A  84
ASN A  88
ASN A 131
ASN A 164
LYS A 167
 RBF  A 190 (-4.6A)
RBF  A 190 (-3.0A)
RBF  A 190 (-3.1A)
RBF  A 190 ( 4.9A)
RBF  A 190 (-3.6A)
RBF  A 190 (-3.3A)
RBF  A 190 (-3.2A)
 0.82A 5kbwA-3p5nA:
24.2		 5kbwA-3p5nA:
33.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3p5n RIBOFLAVIN UPTAKE
PROTEIN
(Staphylococcus
aureus) 		6 / 12 LEU A  42
ASP A  81
GLY A  84
LEU A 127
ASN A 164
LYS A 167
 RBF  A 190 (-4.6A)
RBF  A 190 (-3.0A)
RBF  A 190 (-3.1A)
RBF  A 190 (-4.1A)
RBF  A 190 (-3.3A)
RBF  A 190 (-3.2A)
 1.38A 5kbwA-3p5nA:
24.2		 5kbwA-3p5nA:
33.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3p5n RIBOFLAVIN UPTAKE
PROTEIN
(Staphylococcus
aureus) 		5 / 12 ASP A  81
GLY A  84
ASN A  88
ASN A 131
ASN A 164
 RBF  A 190 (-3.0A)
RBF  A 190 (-3.1A)
RBF  A 190 ( 4.9A)
RBF  A 190 (-3.6A)
RBF  A 190 (-3.3A)
 0.65A 5kbwB-3p5nA:
24.1		 5kbwB-3p5nA:
33.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3p5n RIBOFLAVIN UPTAKE
PROTEIN
(Staphylococcus
aureus) 		5 / 12 ASP A  81
GLY A  84
ASN A  88
ASN A 131
LYS A 167
 RBF  A 190 (-3.0A)
RBF  A 190 (-3.1A)
RBF  A 190 ( 4.9A)
RBF  A 190 (-3.6A)
RBF  A 190 (-3.2A)
 0.73A 5kbwB-3p5nA:
24.1		 5kbwB-3p5nA:
33.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3p5n RIBOFLAVIN UPTAKE
PROTEIN
(Staphylococcus
aureus) 		5 / 12 LEU A  42
GLY A  84
ASN A  88
ASN A 131
ASN A 164
 RBF  A 190 (-4.6A)
RBF  A 190 (-3.1A)
RBF  A 190 ( 4.9A)
RBF  A 190 (-3.6A)
RBF  A 190 (-3.3A)
 0.49A 5kbwB-3p5nA:
24.1		 5kbwB-3p5nA:
33.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3p5n RIBOFLAVIN UPTAKE
PROTEIN
(Staphylococcus
aureus) 		5 / 12 LEU A  42
GLY A  84
ASN A  88
ASN A 131
LYS A 167
 RBF  A 190 (-4.6A)
RBF  A 190 (-3.1A)
RBF  A 190 ( 4.9A)
RBF  A 190 (-3.6A)
RBF  A 190 (-3.2A)
 0.56A 5kbwB-3p5nA:
24.1		 5kbwB-3p5nA:
33.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KC0_A_RBFA303_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3p5n RIBOFLAVIN UPTAKE
PROTEIN
(Staphylococcus
aureus) 		7 / 12 LEU A  42
ASP A  81
GLY A  84
ASN A  88
ASN A 131
ASN A 164
LYS A 167
 RBF  A 190 (-4.6A)
RBF  A 190 (-3.0A)
RBF  A 190 (-3.1A)
RBF  A 190 ( 4.9A)
RBF  A 190 (-3.6A)
RBF  A 190 (-3.3A)
RBF  A 190 (-3.2A)
 1.00A 5kc0A-3p5nA:
24.0		 5kc0A-3p5nA:
31.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KC4_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3p5n RIBOFLAVIN UPTAKE
PROTEIN
(Staphylococcus
aureus) 		7 / 12 LEU A  42
ASP A  81
GLY A  84
ASN A  88
ASN A 131
ASN A 164
LYS A 167
 RBF  A 190 (-4.6A)
RBF  A 190 (-3.0A)
RBF  A 190 (-3.1A)
RBF  A 190 ( 4.9A)
RBF  A 190 (-3.6A)
RBF  A 190 (-3.3A)
RBF  A 190 (-3.2A)
 1.04A 5kc4A-3p5nA:
23.6		 5kc4A-3p5nA:
33.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3p5n RIBOFLAVIN UPTAKE
PROTEIN
(Staphylococcus
aureus) 		8 / 12 LEU A  42
ASP A  81
GLY A  84
ASN A  88
ASN A 131
PHE A 163
ASN A 164
LYS A 167
 RBF  A 190 (-4.6A)
RBF  A 190 (-3.0A)
RBF  A 190 (-3.1A)
RBF  A 190 ( 4.9A)
RBF  A 190 (-3.6A)
RBF  A 190 (-4.5A)
RBF  A 190 (-3.3A)
RBF  A 190 (-3.2A)
 0.95A 5kc4E-3p5nA:
23.4		 5kc4E-3p5nA:
33.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3p5n RIBOFLAVIN UPTAKE
PROTEIN
(Staphylococcus
aureus) 		7 / 12 LEU A  42
ASP A  81
GLY A  84
LEU A 127
PHE A 163
ASN A 164
LYS A 167
 RBF  A 190 (-4.6A)
RBF  A 190 (-3.0A)
RBF  A 190 (-3.1A)
RBF  A 190 (-4.1A)
RBF  A 190 (-4.5A)
RBF  A 190 (-3.3A)
RBF  A 190 (-3.2A)
 1.29A 5kc4E-3p5nA:
23.4		 5kc4E-3p5nA:
33.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 3p5n RIBOFLAVIN UPTAKE
PROTEIN
(Staphylococcus
aureus) 		5 / 12 ILE A 171
LEU A  90
PRO A  60
THR A  55
LEU A  52
 None
 1.22A 5xxiA-3p5nA:
undetectable		 5xxiA-3p5nA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 3p5n RIBOFLAVIN UPTAKE
PROTEIN
(Staphylococcus
aureus) 		5 / 12 VAL A  49
ASP A  48
GLY A  84
ALA A  91
SER A 128
 None
None
RBF  A 190 (-3.1A)
RBF  A 190 (-3.4A)
None
 1.01A 6c2mC-3p5nA:
undetectable		 6c2mC-3p5nA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 3p5n RIBOFLAVIN UPTAKE
PROTEIN
(Staphylococcus
aureus) 		5 / 12 VAL A  49
ASP A  48
GLY A  84
ALA A  91
VAL A 126
 None
None
RBF  A 190 (-3.1A)
RBF  A 190 (-3.4A)
None
 0.97A 6c2mC-3p5nA:
undetectable		 6c2mC-3p5nA:
17.49