SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3p5u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 3p5u ACTINIDIN
(Actinidia
arguta) 		5 / 10 PRO A 132
VAL A 128
VAL A  13
ILE A 196
GLY A 168
 None
 1.49A 13gsA-3p5uA:
undetectable		 13gsA-3p5uA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		 3p5u ACTINIDIN
(Actinidia
arguta) 		5 / 9 PRO A 132
VAL A 128
VAL A  13
ILE A 196
GLY A 168
 None
 1.49A 13gsB-3p5uA:
undetectable		 13gsB-3p5uA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 3p5u ACTINIDIN
(Actinidia
arguta) 		3 / 3 ALA A  33
VAL A 167
TRP A   7
 None
 1.00A 1c4dA-3p5uA:
undetectable
1c4dB-3p5uA:
undetectable		 1c4dA-3p5uA:
5.95
1c4dB-3p5uA:
5.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 3p5u ACTINIDIN
(Actinidia
arguta) 		7 / 10 GLN A  19
GLY A  23
SER A  24
PHE A  28
SER A  29
ALA A 163
GLY A  67
 CD  A 221 ( 4.2A)
None
None
None
None
None
None
 1.17A 1stfE-3p5uA:
36.9
1stfI-3p5uA:
undetectable		 1stfE-3p5uA:
48.66
1stfI-3p5uA:
16.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 3p5u ACTINIDIN
(Actinidia
arguta) 		8 / 10 GLN A  19
GLY A  23
SER A  24
TRP A  26
PHE A  28
SER A  29
HIS A 162
ALA A 163
 CD  A 221 ( 4.2A)
None
None
None
None
None
CD  A 221 (-3.3A)
None
 0.39A 1stfE-3p5uA:
36.9
1stfI-3p5uA:
undetectable		 1stfE-3p5uA:
48.66
1stfI-3p5uA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 3p5u ACTINIDIN
(Actinidia
arguta) 		4 / 7 GLN A  19
GLY A  23
HIS A 162
TRP A 184
 CD  A 221 ( 4.2A)
None
CD  A 221 (-3.3A)
None
 0.35A 3ai8A-3p5uA:
27.6		 3ai8A-3p5uA:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3p5u ACTINIDIN
(Actinidia
arguta) 		4 / 7 VAL A 133
VAL A  13
ILE A  40
ARG A 198
 None
 1.19A 3ms9B-3p5uA:
undetectable		 3ms9B-3p5uA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3p5u ACTINIDIN
(Actinidia
arguta) 		4 / 6 TYR A 113
ILE A  78
SER A 134
SER A 213
 None
 1.11A 3pmzD-3p5uA:
undetectable		 3pmzD-3p5uA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3p5u ACTINIDIN
(Actinidia
arguta) 		4 / 6 ILE A 196
ILE A  16
ILE A 166
LEU A 137
 None
 0.78A 4o8fB-3p5uA:
undetectable		 4o8fB-3p5uA:
21.38