SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3p6b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 3p6b CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 GLU A 132
TRP A 138
LYS A 197
 None
 1.05A 1qu2A-3p6bA:
undetectable		 1qu2A-3p6bA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3p6b CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		4 / 6 LEU A  37
TRP A  50
LEU A 185
PHE A 169
 None
 1.47A 1ru9H-3p6bA:
undetectable
1ru9L-3p6bA:
2.0		 1ru9H-3p6bA:
19.92
1ru9L-3p6bA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 3p6b CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A 190
PHE A 167
ILE A 123
LEU A  99
ASP A 162
 None
 1.28A 3ko0G-3p6bA:
undetectable
3ko0H-3p6bA:
undetectable
3ko0I-3p6bA:
undetectable
3ko0J-3p6bA:
undetectable		 3ko0G-3p6bA:
20.71
3ko0H-3p6bA:
20.71
3ko0I-3p6bA:
20.71
3ko0J-3p6bA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 3p6b CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		5 / 11 LEU A  99
ASP A 162
LEU A 190
PHE A 167
ILE A 123
 None
 1.28A 3ko0A-3p6bA:
undetectable
3ko0B-3p6bA:
undetectable
3ko0I-3p6bA:
undetectable
3ko0J-3p6bA:
undetectable		 3ko0A-3p6bA:
20.71
3ko0B-3p6bA:
20.71
3ko0I-3p6bA:
20.71
3ko0J-3p6bA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3p6b CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		4 / 6 ASN A  73
GLU A  44
GLU A  39
PHE A  42
 CA  A 205 (-3.2A)
None
None
None
 1.49A 4twdG-3p6bA:
undetectable
4twdH-3p6bA:
undetectable		 4twdG-3p6bA:
19.87
4twdH-3p6bA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 3p6b CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 LYS A  74
VAL A  64
ASP A  66
 None
 0.42A 6fgdA-3p6bA:
undetectable		 6fgdA-3p6bA:
18.14