SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3p7m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 3p7m MALATE DEHYDROGENASE
(Francisella
tularensis) 		6 / 9 VAL A   9
GLY A  10
ASP A  34
ILE A  35
TYR A  66
ALA A  79
 None
 0.48A 1cetA-3p7mA:
43.6		 1cetA-3p7mA:
46.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3p7m MALATE DEHYDROGENASE
(Francisella
tularensis) 		4 / 8 VAL A 284
GLY A 283
VAL A  74
ILE A 117
 None
 0.82A 2a1mB-3p7mA:
undetectable		 2a1mB-3p7mA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 3p7m MALATE DEHYDROGENASE
(Francisella
tularensis) 		4 / 6 GLN A 241
GLU A 244
LYS A  25
LEU A  27
 None
 0.68A 3h5gA-3p7mA:
undetectable
3h5gC-3p7mA:
undetectable		 3h5gA-3p7mA:
7.58
3h5gC-3p7mA:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 3p7m MALATE DEHYDROGENASE
(Francisella
tularensis) 		4 / 6 LYS A  25
LEU A  27
GLN A 241
GLU A 244
 None
 1.11A 3h5gB-3p7mA:
undetectable
3h5gC-3p7mA:
undetectable		 3h5gB-3p7mA:
7.58
3h5gC-3p7mA:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 3p7m MALATE DEHYDROGENASE
(Francisella
tularensis) 		4 / 4 PRO A 286
THR A 277
GLY A 175
THR A 179
 None
 0.99A 3ib1A-3p7mA:
1.8		 3ib1A-3p7mA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 3p7m MALATE DEHYDROGENASE
(Francisella
tularensis) 		5 / 12 ILE A   6
LEU A 247
GLY A 239
ILE A  76
ASN A 121
 None
 1.08A 4o1eA-3p7mA:
undetectable		 4o1eA-3p7mA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 3p7m MALATE DEHYDROGENASE
(Francisella
tularensis) 		5 / 12 ILE A   6
LEU A 247
GLY A 239
ILE A  76
ASN A 121
 None
 1.11A 4o1eB-3p7mA:
undetectable		 4o1eB-3p7mA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 3p7m MALATE DEHYDROGENASE
(Francisella
tularensis) 		5 / 12 ALA A 151
SER A 150
GLY A 146
ALA A 243
GLY A 239
 None
 0.99A 4r29A-3p7mA:
undetectable		 4r29A-3p7mA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 3p7m MALATE DEHYDROGENASE
(Francisella
tularensis) 		5 / 12 ALA A 151
SER A 150
GLY A 146
ALA A 243
GLY A 239
 None
 0.98A 4r29B-3p7mA:
undetectable		 4r29B-3p7mA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 3p7m MALATE DEHYDROGENASE
(Francisella
tularensis) 		5 / 12 ALA A 151
SER A 150
GLY A 146
ALA A 243
GLY A 239
 None
 1.01A 4r29C-3p7mA:
undetectable		 4r29C-3p7mA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 3p7m MALATE DEHYDROGENASE
(Francisella
tularensis) 		5 / 12 ALA A 151
SER A 150
GLY A 146
ALA A 243
GLY A 239
 None
 0.98A 4r29D-3p7mA:
undetectable		 4r29D-3p7mA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 3p7m MALATE DEHYDROGENASE
(Francisella
tularensis) 		3 / 3 VAL A  31
THR A  63
ARG A  61
 None
 0.76A 5b2sB-3p7mA:
undetectable		 5b2sB-3p7mA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 3p7m MALATE DEHYDROGENASE
(Francisella
tularensis) 		3 / 3 VAL A  31
THR A  63
ARG A  61
 None
 0.79A 5b2tB-3p7mA:
4.0		 5b2tB-3p7mA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 3p7m MALATE DEHYDROGENASE
(Francisella
tularensis) 		3 / 3 LEU A 247
SER A 245
PHE A 246
 None
 0.64A 6fgcA-3p7mA:
3.7		 6fgcA-3p7mA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 3p7m MALATE DEHYDROGENASE
(Francisella
tularensis) 		5 / 12 ILE A 107
VAL A  75
THR A   7
PHE A  33
PRO A  40
 None
 1.19A 6hlpA-3p7mA:
7.2		 6hlpA-3p7mA:
21.59