SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3p7n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 3p7n SENSOR HISTIDINE
KINASE
(Erythrobacter
litoralis) 		4 / 5 LEU A 187
ALA A 185
LEU A 189
SER A 190
 None
 1.10A 1tt6B-3p7nA:
undetectable		 1tt6B-3p7nA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 3p7n SENSOR HISTIDINE
KINASE
(Erythrobacter
litoralis) 		4 / 6 LEU A 102
ALA A 118
LEU A 120
SER A  40
 None
 0.93A 1tz8C-3p7nA:
undetectable
1tz8D-3p7nA:
undetectable		 1tz8C-3p7nA:
18.04
1tz8D-3p7nA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3p7n SENSOR HISTIDINE
KINASE
(Erythrobacter
litoralis) 		5 / 10 LEU A  52
ALA A  54
ILE A  55
ALA A 211
LEU A 120
 None
 1.16A 1xp0A-3p7nA:
undetectable		 1xp0A-3p7nA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 3p7n SENSOR HISTIDINE
KINASE
(Erythrobacter
litoralis) 		5 / 12 LEU A 102
ASN A 107
ILE A  38
THR A 209
LEU A 135
 None
FMN  A 500 (-3.1A)
None
None
None
 1.30A 3a51B-3p7nA:
undetectable		 3a51B-3p7nA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 3p7n SENSOR HISTIDINE
KINASE
(Erythrobacter
litoralis) 		4 / 8 ALA A  79
THR A  88
ILE A 105
THR A  83
 FMN  A 500 ( 4.5A)
FMN  A 500 (-3.7A)
FMN  A 500 (-4.1A)
None
 0.97A 3bpxA-3p7nA:
undetectable
3bpxB-3p7nA:
4.7		 3bpxA-3p7nA:
19.92
3bpxB-3p7nA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3p7n SENSOR HISTIDINE
KINASE
(Erythrobacter
litoralis) 		4 / 5 SER A 210
ARG A 198
ARG A 179
GLU A 130
 None
 1.22A 3k9fA-3p7nA:
undetectable
3k9fB-3p7nA:
undetectable
3k9fC-3p7nA:
undetectable		 3k9fA-3p7nA:
18.80
3k9fB-3p7nA:
18.80
3k9fC-3p7nA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3p7n SENSOR HISTIDINE
KINASE
(Erythrobacter
litoralis) 		4 / 6 MET A 159
ILE A 216
SER A  40
SER A 137
 None
 1.18A 3pmzD-3p7nA:
undetectable		 3pmzD-3p7nA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 3p7n SENSOR HISTIDINE
KINASE
(Erythrobacter
litoralis) 		3 / 3 LEU A 200
HIS A 197
MET A 196
 None
 0.81A 3thrD-3p7nA:
undetectable		 3thrD-3p7nA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 3p7n SENSOR HISTIDINE
KINASE
(Erythrobacter
litoralis) 		4 / 7 GLY A 149
ALA A 151
ALA A 156
ARG A 155
 None
 0.83A 3ur0B-3p7nA:
undetectable		 3ur0B-3p7nA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 3p7n SENSOR HISTIDINE
KINASE
(Erythrobacter
litoralis) 		4 / 8 SER A  40
ALA A 118
LEU A 120
SER A 137
 None
 0.57A 4iklA-3p7nA:
undetectable
4iklB-3p7nA:
undetectable		 4iklA-3p7nA:
18.04
4iklB-3p7nA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_1
(BLUE-LIGHT
PHOTORECEPTOR)		 3p7n SENSOR HISTIDINE
KINASE
(Erythrobacter
litoralis) 		5 / 12 ASN A  74
CYH A  75
ASN A 117
ILE A  91
GLN A 138
 FMN  A 500 (-3.1A)
FMN  A 500 (-3.3A)
FMN  A 500 (-4.1A)
FMN  A 500 (-3.9A)
FMN  A 500 (-3.9A)
 1.12A 4kukA-3p7nA:
19.3		 4kukA-3p7nA:
29.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_1
(BLUE-LIGHT
PHOTORECEPTOR)		 3p7n SENSOR HISTIDINE
KINASE
(Erythrobacter
litoralis) 		9 / 12 VAL A  41
SER A  43
ASN A  50
ASN A  74
CYH A  75
ARG A  76
ASN A 107
ASN A 117
GLN A 138
 None
FMN  A 500 (-3.4A)
FMN  A 500 (-3.9A)
FMN  A 500 (-3.1A)
FMN  A 500 (-3.3A)
FMN  A 500 (-3.8A)
FMN  A 500 (-3.1A)
FMN  A 500 (-4.1A)
FMN  A 500 (-3.9A)
 0.46A 4kukA-3p7nA:
19.3		 4kukA-3p7nA:
29.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_1
(BLUE-LIGHT
PHOTORECEPTOR)		 3p7n SENSOR HISTIDINE
KINASE
(Erythrobacter
litoralis) 		6 / 12 VAL A  41
SER A  43
ASN A  50
ASN A  74
CYH A  75
ASN A 107
 None
FMN  A 500 (-3.4A)
FMN  A 500 (-3.9A)
FMN  A 500 (-3.1A)
FMN  A 500 (-3.3A)
FMN  A 500 (-3.1A)
 1.21A 4kukA-3p7nA:
19.3		 4kukA-3p7nA:
29.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_1
(BLUE-LIGHT
PHOTORECEPTOR)		 3p7n SENSOR HISTIDINE
KINASE
(Erythrobacter
litoralis) 		5 / 12 VAL A 121
ASN A 117
ASN A 107
ASN A  74
LEU A  52
 FMN  A 500 (-4.5A)
FMN  A 500 (-4.1A)
FMN  A 500 (-3.1A)
FMN  A 500 (-3.1A)
None
 1.49A 4kukA-3p7nA:
19.3		 4kukA-3p7nA:
29.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 3p7n SENSOR HISTIDINE
KINASE
(Erythrobacter
litoralis) 		5 / 9 LEU A  78
ILE A  91
ILE A 105
PHE A 134
GLY A 136
 FMN  A 500 (-4.6A)
FMN  A 500 (-3.9A)
FMN  A 500 (-4.1A)
None
FMN  A 500 ( 4.0A)
 0.38A 4kukA-3p7nA:
19.3		 4kukA-3p7nA:
29.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUO_A_RBFA500_1
(BLUE-LIGHT
PHOTORECEPTOR)		 3p7n SENSOR HISTIDINE
KINASE
(Erythrobacter
litoralis) 		9 / 12 VAL A  41
SER A  43
ASN A  50
ASN A  74
CYH A  75
ARG A  76
ASN A 107
ASN A 117
GLN A 138
 None
FMN  A 500 (-3.4A)
FMN  A 500 (-3.9A)
FMN  A 500 (-3.1A)
FMN  A 500 (-3.3A)
FMN  A 500 (-3.8A)
FMN  A 500 (-3.1A)
FMN  A 500 (-4.1A)
FMN  A 500 (-3.9A)
 0.49A 4kuoA-3p7nA:
18.9		 4kuoA-3p7nA:
29.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUO_A_RBFA500_1
(BLUE-LIGHT
PHOTORECEPTOR)		 3p7n SENSOR HISTIDINE
KINASE
(Erythrobacter
litoralis) 		5 / 12 VAL A  41
SER A  43
ASN A  50
CYH A  75
ASN A 117
 None
FMN  A 500 (-3.4A)
FMN  A 500 (-3.9A)
FMN  A 500 (-3.3A)
FMN  A 500 (-4.1A)
 1.05A 4kuoA-3p7nA:
18.9		 4kuoA-3p7nA:
29.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUO_A_RBFA500_1
(BLUE-LIGHT
PHOTORECEPTOR)		 3p7n SENSOR HISTIDINE
KINASE
(Erythrobacter
litoralis) 		5 / 12 VAL A 121
ASN A 117
ASN A 107
ASN A  74
LEU A  52
 FMN  A 500 (-4.5A)
FMN  A 500 (-4.1A)
FMN  A 500 (-3.1A)
FMN  A 500 (-3.1A)
None
 1.49A 4kuoA-3p7nA:
18.9		 4kuoA-3p7nA:
29.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 3p7n SENSOR HISTIDINE
KINASE
(Erythrobacter
litoralis) 		3 / 3 GLU A 169
THR A 193
HIS A 197
 None
 0.82A 4q15A-3p7nA:
undetectable		 4q15A-3p7nA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 3p7n SENSOR HISTIDINE
KINASE
(Erythrobacter
litoralis) 		3 / 3 GLU A 169
THR A 193
HIS A 197
 None
 0.81A 4q15B-3p7nA:
undetectable		 4q15B-3p7nA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3p7n SENSOR HISTIDINE
KINASE
(Erythrobacter
litoralis) 		6 / 12 CYH A  75
ARG A  76
ASN A 107
ASN A 117
GLY A 136
GLN A 138
 FMN  A 500 (-3.3A)
FMN  A 500 (-3.8A)
FMN  A 500 (-3.1A)
FMN  A 500 (-4.1A)
FMN  A 500 ( 4.0A)
FMN  A 500 (-3.9A)
 0.63A 4r38A-3p7nA:
18.7		 4r38A-3p7nA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3p7n SENSOR HISTIDINE
KINASE
(Erythrobacter
litoralis) 		7 / 12 ASN A  74
CYH A  75
ARG A  76
ASN A 107
ASN A 117
GLY A 136
GLN A 138
 FMN  A 500 (-3.1A)
FMN  A 500 (-3.3A)
FMN  A 500 (-3.8A)
FMN  A 500 (-3.1A)
FMN  A 500 (-4.1A)
FMN  A 500 ( 4.0A)
FMN  A 500 (-3.9A)
 0.66A 4r38B-3p7nA:
18.7		 4r38B-3p7nA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3p7n SENSOR HISTIDINE
KINASE
(Erythrobacter
litoralis) 		6 / 12 CYH A  75
ARG A  76
ASN A 107
ASN A 117
GLY A 136
GLN A 138
 FMN  A 500 (-3.3A)
FMN  A 500 (-3.8A)
FMN  A 500 (-3.1A)
FMN  A 500 (-4.1A)
FMN  A 500 ( 4.0A)
FMN  A 500 (-3.9A)
 0.65A 4r38C-3p7nA:
8.1		 4r38C-3p7nA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3p7n SENSOR HISTIDINE
KINASE
(Erythrobacter
litoralis) 		6 / 12 CYH A  75
ARG A  76
ASN A 107
ASN A 117
GLY A 136
GLN A 138
 FMN  A 500 (-3.3A)
FMN  A 500 (-3.8A)
FMN  A 500 (-3.1A)
FMN  A 500 (-4.1A)
FMN  A 500 ( 4.0A)
FMN  A 500 (-3.9A)
 0.66A 4r38D-3p7nA:
18.6		 4r38D-3p7nA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3p7n SENSOR HISTIDINE
KINASE
(Erythrobacter
litoralis) 		6 / 12 CYH A  75
ARG A  76
ILE A 105
ASN A 107
ASN A 117
GLN A 138
 FMN  A 500 (-3.3A)
FMN  A 500 (-3.8A)
FMN  A 500 (-4.1A)
FMN  A 500 (-3.1A)
FMN  A 500 (-4.1A)
FMN  A 500 (-3.9A)
 0.48A 4r3aA-3p7nA:
14.7		 4r3aA-3p7nA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3p7n SENSOR HISTIDINE
KINASE
(Erythrobacter
litoralis) 		8 / 12 LEU A  52
CYH A  75
ARG A  76
ILE A 105
ASN A 107
ASN A 117
GLY A 136
GLN A 138
 None
FMN  A 500 (-3.3A)
FMN  A 500 (-3.8A)
FMN  A 500 (-4.1A)
FMN  A 500 (-3.1A)
FMN  A 500 (-4.1A)
FMN  A 500 ( 4.0A)
FMN  A 500 (-3.9A)
 0.51A 4r3aB-3p7nA:
14.5		 4r3aB-3p7nA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 3p7n SENSOR HISTIDINE
KINASE
(Erythrobacter
litoralis) 		3 / 3 GLU A 169
THR A 193
HIS A 197
 None
 0.75A 4ydqB-3p7nA:
undetectable		 4ydqB-3p7nA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3p7n SENSOR HISTIDINE
KINASE
(Erythrobacter
litoralis) 		4 / 5 SER A 210
ARG A 179
GLU A 130
ARG A 198
 None
 0.96A 5cdqA-3p7nA:
undetectable
5cdqB-3p7nA:
undetectable
5cdqC-3p7nA:
undetectable		 5cdqA-3p7nA:
22.53
5cdqB-3p7nA:
22.18
5cdqC-3p7nA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3p7n SENSOR HISTIDINE
KINASE
(Erythrobacter
litoralis) 		4 / 5 SER A 210
ARG A 179
GLU A 130
ARG A 198
 None
 0.98A 5cdqR-3p7nA:
undetectable
5cdqS-3p7nA:
undetectable
5cdqT-3p7nA:
undetectable		 5cdqR-3p7nA:
22.53
5cdqS-3p7nA:
22.18
5cdqT-3p7nA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 3p7n SENSOR HISTIDINE
KINASE
(Erythrobacter
litoralis) 		4 / 6 LEU A 187
ALA A 185
LEU A 189
SER A 190
 None
 1.04A 5l4iA-3p7nA:
undetectable		 5l4iA-3p7nA:
18.04