SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3p83'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 3p83 RIBONUCLEASE HII
(Archaeoglobus
fulgidus) 		5 / 9 ILE D  90
PRO D  95
ALA D   3
ILE D   5
THR D 118
 None
 1.43A 1aj6A-3p83D:
undetectable		 1aj6A-3p83D:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 3p83 RIBONUCLEASE HII
(Archaeoglobus
fulgidus) 		4 / 6 LEU D 110
ILE D 106
ASP D 104
PRO D 103
 None
 1.12A 1ditH-3p83D:
undetectable
1ditP-3p83D:
undetectable		 1ditH-3p83D:
24.26
1ditP-3p83D:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 3p83 RIBONUCLEASE HII
(Archaeoglobus
fulgidus) 		5 / 11 VAL D 123
TYR D  99
GLU D 115
GLY D 119
PRO D  95
 None
 0.90A 1i9jH-3p83D:
undetectable
1i9jL-3p83D:
undetectable		 1i9jH-3p83D:
21.74
1i9jL-3p83D:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1122_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3p83 RIBONUCLEASE HII
(Archaeoglobus
fulgidus) 		4 / 7 SER D  38
LYS D  39
VAL D  35
SER D 139
 None
 1.45A 2j9cA-3p83D:
undetectable
2j9cB-3p83D:
undetectable
2j9cC-3p83D:
undetectable		 2j9cA-3p83D:
19.37
2j9cB-3p83D:
19.37
2j9cC-3p83D:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1122_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3p83 RIBONUCLEASE HII
(Archaeoglobus
fulgidus) 		4 / 7 SER D 139
VAL D 135
SER D  38
LYS D  39
 None
 1.27A 2j9cA-3p83D:
undetectable
2j9cB-3p83D:
undetectable
2j9cC-3p83D:
undetectable		 2j9cA-3p83D:
19.37
2j9cB-3p83D:
19.37
2j9cC-3p83D:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 3p83 RIBONUCLEASE HII
(Archaeoglobus
fulgidus) 		5 / 10 ILE D  78
SER D  65
ASN D  68
ILE D  81
GLU D  84
 None
 1.41A 3u6tA-3p83D:
undetectable		 3u6tA-3p83D:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3p83 RIBONUCLEASE HII
(Archaeoglobus
fulgidus) 		4 / 6 VAL D 194
VAL D  13
ILE D  14
TRP D 177
 None
 0.71A 4l1wB-3p83D:
undetectable		 4l1wB-3p83D:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3p83 RIBONUCLEASE HII
(Archaeoglobus
fulgidus) 		4 / 8 LEU D  30
LEU D  33
VAL D  35
ILE D 140
 None
 0.92A 4oj4A-3p83D:
undetectable		 4oj4A-3p83D:
21.20