SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3p8c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQB_A_RTLA185_0
(RETINOL-BINDING
PROTEIN)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 10 ALA B 243
VAL B 419
MET B 248
TYR B 252
LEU B 375
 None
 1.49A 1aqbA-3p8cB:
undetectable		 1aqbA-3p8cB:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		3 / 3 MET B 144
LEU B 147
SER B 148
 None
 0.52A 1ee2A-3p8cB:
undetectable		 1ee2A-3p8cB:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 THR B 536
ARG B 343
LEU B 375
LEU B 408
LEU B 230
 None
CL  B1131 (-3.8A)
None
None
None
 1.25A 1eiiA-3p8cB:
undetectable		 1eiiA-3p8cB:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 8 MET B1000
ALA B1062
LEU B1088
LEU B1087
 None
 0.83A 1ereE-3p8cB:
undetectable		 1ereE-3p8cB:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 8 MET B1000
ALA B1062
LEU B1088
LEU B1087
 None
 0.84A 1ereF-3p8cB:
undetectable		 1ereF-3p8cB:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 11 LEU B 375
ALA B 378
LEU B 408
HIS B 575
LEU B 539
 None
 1.09A 1g50A-3p8cB:
undetectable		 1g50A-3p8cB:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU B 375
ALA B 378
LEU B 408
HIS B 575
LEU B 539
 None
 1.16A 1gwrA-3p8cB:
undetectable		 1gwrA-3p8cB:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 11 ALA B 243
ALA B 368
MET B 248
TYR B 252
LEU B 375
 None
 1.35A 1hbpA-3p8cB:
undetectable		 1hbpA-3p8cB:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 6 PRO B 736
ASN B 727
TRP B 791
TYR B 830
 None
 1.40A 1hpkA-3p8cB:
undetectable		 1hpkA-3p8cB:
4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 4 GLY B  26
LEU B 583
GLY B  24
ARG B  23
 None
 1.47A 1j7kA-3p8cB:
undetectable		 1j7kA-3p8cB:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3p8c PROBABLE PROTEIN
BRICK1
WISKOTT-ALDRICH
SYNDROME PROTEIN
FAMILY MEMBER 1
(Homo
sapiens) 		4 / 6 ALA E  66
GLU E  65
LEU D  76
LEU D  83
 None
 0.91A 1mt1D-3p8cE:
undetectable
1mt1E-3p8cE:
undetectable		 1mt1D-3p8cE:
24.55
1mt1E-3p8cE:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 PHE B 311
LEU B 273
TYR B 317
LEU B 268
LEU B 189
 None
 1.44A 1p33C-3p8cB:
undetectable		 1p33C-3p8cB:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU B 375
ALA B 378
LEU B 408
HIS B 575
LEU B 539
 None
 1.12A 1pcgA-3p8cB:
undetectable		 1pcgA-3p8cB:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU B 375
ALA B 378
LEU B 408
HIS B 575
LEU B 539
 None
 1.13A 1pcgB-3p8cB:
undetectable		 1pcgB-3p8cB:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE B 541
MET B 412
LEU B 572
PHE B 542
ILE B 405
 None
 1.22A 1rh3A-3p8cB:
undetectable		 1rh3A-3p8cB:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_A_BEZA881_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 3p8c WISKOTT-ALDRICH
SYNDROME PROTEIN
FAMILY MEMBER 1
PROBABLE PROTEIN
BRICK1
ABL INTERACTOR 2
(Homo
sapiens;
Homo
sapiens;
Homo
sapiens) 		5 / 11 LEU D  76
TYR E  63
ILE E  64
ARG E  67
VAL F  97
 None
 1.32A 1tmxA-3p8cD:
undetectable		 1tmxA-3p8cD:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 3p8c ABL INTERACTOR 2
(Homo
sapiens) 		4 / 8 ARG F  84
HIS F  92
SER F  88
ARG F  85
 None
 1.27A 1u1jA-3p8cF:
undetectable		 1u1jA-3p8cF:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU B 682
ARG B 705
THR B 709
LEU B 712
 None
 0.92A 1v54A-3p8cB:
1.9
1v54J-3p8cB:
undetectable		 1v54A-3p8cB:
18.35
1v54J-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 7 LEU B 682
ARG B 705
THR B 709
LEU B 712
 None
 0.82A 1v54N-3p8cB:
1.3
1v54W-3p8cB:
undetectable		 1v54N-3p8cB:
18.35
1v54W-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 7 LEU B 682
ARG B 705
THR B 709
LEU B 712
 None
 0.87A 1v55A-3p8cB:
1.5
1v55J-3p8cB:
undetectable		 1v55A-3p8cB:
18.35
1v55J-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 7 LEU B 375
PHE B 521
MET B 525
VAL B 526
 None
 0.82A 1wrlA-3p8cB:
undetectable
1wrlB-3p8cB:
undetectable		 1wrlA-3p8cB:
6.33
1wrlB-3p8cB:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		3 / 3 LEU B  28
PHE B 296
ARG B 588
 None
 0.83A 1xdkF-3p8cB:
3.5		 1xdkF-3p8cB:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU B 999
LEU B1043
ILE B 910
SER B 860
ALA B 864
 None
 1.04A 2bxqA-3p8cB:
4.3		 2bxqA-3p8cB:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 11 PHE B 687
TYR B 411
THR B 355
ALA B 354
TYR B 691
 None
 1.38A 2cojA-3p8cB:
undetectable
2cojB-3p8cB:
undetectable		 2cojA-3p8cB:
16.52
2cojB-3p8cB:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU B 682
ARG B 705
THR B 709
LEU B 712
 None
 0.98A 2dyrA-3p8cB:
1.4
2dyrJ-3p8cB:
undetectable		 2dyrA-3p8cB:
18.35
2dyrJ-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 7 LEU B 682
ARG B 705
THR B 709
LEU B 712
 None
 0.91A 2dyrN-3p8cB:
1.4
2dyrW-3p8cB:
undetectable		 2dyrN-3p8cB:
18.35
2dyrW-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU B 682
ARG B 705
THR B 709
LEU B 712
 None
 1.00A 2dysA-3p8cB:
undetectable
2dysJ-3p8cB:
undetectable		 2dysA-3p8cB:
18.35
2dysJ-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU B 682
ARG B 705
THR B 709
LEU B 712
 None
 0.82A 2dysN-3p8cB:
1.5
2dysW-3p8cB:
undetectable		 2dysN-3p8cB:
18.35
2dysW-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU B 682
ARG B 705
THR B 709
LEU B 712
 None
 0.92A 2eijA-3p8cB:
1.6
2eijJ-3p8cB:
undetectable		 2eijA-3p8cB:
18.35
2eijJ-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU B 682
ARG B 705
THR B 709
LEU B 712
 None
 0.85A 2eilA-3p8cB:
3.2
2eilJ-3p8cB:
undetectable		 2eilA-3p8cB:
18.35
2eilJ-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 8 LEU B 682
ARG B 705
THR B 709
LEU B 712
 None
 0.84A 2eilN-3p8cB:
1.7
2eilW-3p8cB:
undetectable		 2eilN-3p8cB:
18.35
2eilW-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 5 ARG B 149
MET B 144
THR B 142
LEU B 143
 None
 1.34A 2eimJ-3p8cB:
undetectable		 2eimJ-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 5 ARG B 149
MET B 144
THR B 142
LEU B 143
 None
 1.33A 2eimW-3p8cB:
undetectable		 2eimW-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3p8c ABL INTERACTOR 2
(Homo
sapiens) 		5 / 9 LEU F   4
LEU F   7
LEU F   8
ILE F  12
LEU F  76
 None
 1.22A 2f7aB-3p8cF:
undetectable		 2f7aB-3p8cF:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 10 PHE B1058
ALA B1062
THR B1009
LEU B 904
VAL B 900
 None
 1.04A 2wuzA-3p8cB:
undetectable		 2wuzA-3p8cB:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 10 PHE B1058
ALA B1062
THR B1009
LEU B 904
VAL B 900
 None
 1.03A 2wuzB-3p8cB:
undetectable		 2wuzB-3p8cB:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 3p8c PROBABLE PROTEIN
BRICK1
ABL INTERACTOR 2
(Homo
sapiens;
Homo
sapiens) 		4 / 7 ASP F  98
VAL E  68
ARG E  67
ILE E  64
 None
 1.06A 2yfbA-3p8cF:
3.2		 2yfbA-3p8cF:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 3p8c PROBABLE PROTEIN
BRICK1
ABL INTERACTOR 2
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ASP F  98
VAL E  68
ARG E  67
ILE E  64
 None
 1.11A 2yfbB-3p8cF:
3.1		 2yfbB-3p8cF:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 11 SER B1006
LEU B 866
VAL B 863
ILE B 910
ALA B1041
 None
 1.21A 2zbzA-3p8cB:
undetectable		 2zbzA-3p8cB:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU B 285
SER B 289
VAL B 213
LEU B 253
LEU B 134
 None
 1.24A 2zlcA-3p8cB:
undetectable		 2zlcA-3p8cB:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU B 682
ARG B 705
THR B 709
LEU B 712
 None
 1.02A 2zxwA-3p8cB:
undetectable
2zxwJ-3p8cB:
undetectable		 2zxwA-3p8cB:
18.35
2zxwJ-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 PRO B 188
ILE B 267
LEU B 189
ILE B 138
LEU B 293
 None
 0.96A 3a50D-3p8cB:
1.5		 3a50D-3p8cB:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 8 LEU B 682
ARG B 705
THR B 709
LEU B 712
 None
 0.90A 3ablN-3p8cB:
1.4
3ablW-3p8cB:
undetectable		 3ablN-3p8cB:
18.35
3ablW-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU B 682
ARG B 705
THR B 709
LEU B 712
 None
 1.03A 3abmA-3p8cB:
undetectable
3abmJ-3p8cB:
undetectable		 3abmA-3p8cB:
18.35
3abmJ-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 5 ARG B 149
MET B 144
THR B 142
LEU B 143
 None
 1.33A 3ag2J-3p8cB:
undetectable		 3ag2J-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 7 LEU B 682
ARG B 705
THR B 709
LEU B 712
 None
 0.92A 3ag3A-3p8cB:
1.1
3ag3J-3p8cB:
undetectable		 3ag3A-3p8cB:
18.35
3ag3J-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 5 ARG B 149
MET B 144
THR B 142
LEU B 143
 None
 1.38A 3ag4J-3p8cB:
undetectable		 3ag4J-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 3p8c ABL INTERACTOR 2
NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 6 ASN F  91
SER F  88
HIS B 945
ASP B 944
 None
 1.17A 3aruA-3p8cF:
undetectable		 3aruA-3p8cF:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU B 682
ARG B 705
THR B 709
LEU B 712
 None
 0.98A 3asnA-3p8cB:
1.6
3asnJ-3p8cB:
undetectable		 3asnA-3p8cB:
18.35
3asnJ-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU B 682
ARG B 705
THR B 709
LEU B 712
 None
 0.97A 3asoA-3p8cB:
1.3
3asoJ-3p8cB:
undetectable		 3asoA-3p8cB:
18.35
3asoJ-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 3p8c WISKOTT-ALDRICH
SYNDROME PROTEIN
FAMILY MEMBER 1
PROBABLE PROTEIN
BRICK1
ABL INTERACTOR 2
(Homo
sapiens;
Homo
sapiens;
Homo
sapiens) 		5 / 11 THR F  54
LYS F  51
LEU D  34
THR D  30
ILE E  22
 None
 1.14A 3bexE-3p8cF:
undetectable
3bexF-3p8cF:
undetectable		 3bexE-3p8cF:
20.16
3bexF-3p8cF:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		3 / 3 PRO B 188
PHE B 196
LYS B 191
 None
 1.24A 3bjwG-3p8cB:
undetectable		 3bjwG-3p8cB:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU B 310
ILE B 145
ARG B 149
LEU B 295
PHE B 264
 None
 1.01A 3datA-3p8cB:
undetectable		 3datA-3p8cB:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 5 ASP B 538
ARG B 297
ILE B 541
THR B 139
 None
 1.12A 3eigA-3p8cB:
undetectable		 3eigA-3p8cB:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 THR B 789
LEU B 979
SER B 860
SER B 918
ILE B1039
 None
 1.26A 3frqA-3p8cB:
undetectable		 3frqA-3p8cB:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU B 596
ARG B 594
THR B 701
CYH B 599
LEU B 598
 GOL  B1132 ( 4.3A)
None
None
None
None
 1.30A 3okxB-3p8cB:
undetectable		 3okxB-3p8cB:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU B 375
ALA B 378
LEU B 408
HIS B 575
LEU B 539
 None
 1.17A 3olsB-3p8cB:
undetectable		 3olsB-3p8cB:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU B 375
ALA B 378
LEU B 408
HIS B 575
LEU B 539
 None
 1.11A 3q95A-3p8cB:
undetectable		 3q95A-3p8cB:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 3p8c WISKOTT-ALDRICH
SYNDROME PROTEIN
FAMILY MEMBER 1
PROBABLE PROTEIN
BRICK1
(Homo
sapiens;
Homo
sapiens) 		5 / 7 ILE E  64
ILE E  61
VAL D  73
LEU D  76
SER D  77
 None
 1.33A 3r9vA-3p8cE:
undetectable
3r9vB-3p8cE:
undetectable		 3r9vA-3p8cE:
15.02
3r9vB-3p8cE:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_2
(PROTEASE)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 9 ARG B 343
LEU B 408
ILE B 541
ILE B 405
ILE B 409
 CL  B1131 (-3.8A)
None
None
None
None
 1.04A 3s56B-3p8cB:
undetectable		 3s56B-3p8cB:
6.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 6 GLN B1038
PHE B1097
PRO B1096
LEU B1055
 None
 1.34A 3tgvD-3p8cB:
undetectable		 3tgvD-3p8cB:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		3 / 3 SER B 254
ASP B 135
ASP B  22
 None
 0.86A 3uj7A-3p8cB:
undetectable		 3uj7A-3p8cB:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 3p8c ABL INTERACTOR 2
(Homo
sapiens) 		4 / 6 PRO F  13
GLY F  15
LEU F  68
ASN F  71
 None
 0.86A 3zqtA-3p8cF:
undetectable		 3zqtA-3p8cF:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 6 ILE B 733
PHE B 825
HIS B 858
VAL B 912
 None
 1.15A 4a97I-3p8cB:
0.1		 4a97I-3p8cB:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 6 ILE B 733
PHE B 825
TYR B 792
VAL B 912
 None
 1.21A 4a97I-3p8cB:
0.1		 4a97I-3p8cB:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 TYR B 545
ALA B 548
ILE B 409
GLU B 413
LEU B 385
 None
 1.13A 4azsA-3p8cB:
undetectable		 4azsA-3p8cB:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 TYR B 545
ALA B 548
ILE B 409
GLU B 413
LEU B 385
 None
 1.12A 4aztA-3p8cB:
undetectable		 4aztA-3p8cB:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 TYR B 545
ALA B 548
ILE B 409
GLU B 413
LEU B 385
 None
 1.10A 4azwA-3p8cB:
undetectable		 4azwA-3p8cB:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		3 / 3 LEU B 255
GLU B 381
SER B 376
 None
 0.81A 4ccqA-3p8cB:
undetectable		 4ccqA-3p8cB:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 6 TYR B1116
HIS B1025
HIS B1030
TYR B1018
 None
 1.38A 4df2A-3p8cB:
undetectable		 4df2A-3p8cB:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 11 LEU B1007
SER B1016
LEU B1067
LEU B1103
ILE B1091
 None
 1.21A 4dm8A-3p8cB:
undetectable		 4dm8A-3p8cB:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 8 TYR B 133
ASP B 115
VAL B 107
PHE B 196
 None
 1.07A 4f8hB-3p8cB:
2.2
4f8hC-3p8cB:
2.2		 4f8hB-3p8cB:
14.75
4f8hC-3p8cB:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 8 VAL B 107
PHE B 196
TYR B 133
ASP B 115
 None
 1.09A 4f8hA-3p8cB:
2.3
4f8hE-3p8cB:
2.2		 4f8hA-3p8cB:
14.75
4f8hE-3p8cB:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 7 TYR B  93
ILE B 156
ASP B 172
PHE B  97
 None
 0.90A 4iqqA-3p8cB:
undetectable		 4iqqA-3p8cB:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		3 / 3 LYS B 735
PRO B 736
SER B 737
 None
 0.45A 4k50I-3p8cB:
2.6		 4k50I-3p8cB:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 9 TYR B 140
ILE B 114
GLU B 195
LEU B 268
LEU B 203
 None
 1.04A 4l1xB-3p8cB:
undetectable		 4l1xB-3p8cB:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 3p8c ABL INTERACTOR 2
NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 5 LEU B 143
ASP B  99
ARG B  23
ILE F 141
 None
 1.47A 4mwrA-3p8cB:
undetectable		 4mwrA-3p8cB:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 6 THR B 615
GLN B 554
LEU B 557
GLU B 558
 None
 0.95A 4nc3A-3p8cB:
1.7		 4nc3A-3p8cB:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA601_1
(SERUM ALBUMIN)		 3p8c ABL INTERACTOR 2
PROBABLE PROTEIN
BRICK1
(Homo
sapiens) 		5 / 12 CYH E  43
LEU E  36
VAL F  72
LEU F  68
ARG F  16
 None
 1.40A 4po0A-3p8cE:
undetectable		 4po0A-3p8cE:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDC_A_ASDA404_1
(3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL B 749
GLN B 621
LEU B 628
SER B 625
ALA B 745
 None
 1.36A 4qdcA-3p8cB:
undetectable		 4qdcA-3p8cB:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 11 LEU B  13
ASP B 128
GLN B 494
ALA B 495
ILE B 123
 None
 1.34A 4uuuA-3p8cB:
undetectable
4uuuB-3p8cB:
undetectable		 4uuuA-3p8cB:
9.42
4uuuB-3p8cB:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 7 ASN B 126
PHE B 491
TRP B 490
PHE B 463
 None
 0.83A 4v32C-3p8cB:
undetectable		 4v32C-3p8cB:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 3p8c ABL INTERACTOR 2
(Homo
sapiens) 		3 / 3 LEU F  83
ARG F  85
ARG F  84
 None
 0.94A 4yiaB-3p8cF:
undetectable		 4yiaB-3p8cF:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVX_B_GMRB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU B1087
HIS B1025
SER B1016
LEU B 904
ASN B1080
 None
 1.45A 4yvxB-3p8cB:
undetectable		 4yvxB-3p8cB:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 3p8c WISKOTT-ALDRICH
SYNDROME PROTEIN
FAMILY MEMBER 1
PROBABLE PROTEIN
BRICK1
ABL INTERACTOR 2
(Homo
sapiens;
Homo
sapiens;
Homo
sapiens) 		4 / 8 ILE D  37
LEU D  41
ILE E  25
LEU F  58
 None
 0.75A 4zvcA-3p8cD:
undetectable
4zvcB-3p8cD:
undetectable		 4zvcA-3p8cD:
17.08
4zvcB-3p8cD:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 3p8c WISKOTT-ALDRICH
SYNDROME PROTEIN
FAMILY MEMBER 1
PROBABLE PROTEIN
BRICK1
ABL INTERACTOR 2
(Homo
sapiens;
Homo
sapiens;
Homo
sapiens) 		4 / 8 ILE E  25
LEU F  58
ILE D  37
LEU D  41
 None
 0.74A 4zvcA-3p8cE:
undetectable
4zvcB-3p8cE:
undetectable		 4zvcA-3p8cE:
21.74
4zvcB-3p8cE:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3p8c NCK-ASSOCIATED
PROTEIN 1
ABL INTERACTOR 2
(Homo
sapiens;
Homo
sapiens) 		4 / 7 LYS F 116
ARG B 763
ASP B 760
ILE B 761
 None
 1.01A 5a06B-3p8cF:
undetectable		 5a06B-3p8cF:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3p8c WISKOTT-ALDRICH
SYNDROME PROTEIN
FAMILY MEMBER 1
PROBABLE PROTEIN
BRICK1
(Homo
sapiens;
Homo
sapiens) 		4 / 7 ARG E  44
ASP E  40
ILE D  51
TYR D  47
 None
 1.35A 5a06B-3p8cE:
undetectable		 5a06B-3p8cE:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 7 LEU B 682
ARG B 705
THR B 709
LEU B 712
 None
 0.81A 5b1aA-3p8cB:
1.5
5b1aJ-3p8cB:
undetectable		 5b1aA-3p8cB:
18.35
5b1aJ-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 7 LEU B 682
ARG B 705
THR B 709
LEU B 712
 None
 0.73A 5b1bA-3p8cB:
3.5
5b1bJ-3p8cB:
undetectable		 5b1bA-3p8cB:
18.35
5b1bJ-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 7 LEU B 682
ARG B 705
THR B 709
LEU B 712
 None
 0.79A 5b3sA-3p8cB:
1.4
5b3sJ-3p8cB:
undetectable		 5b3sA-3p8cB:
18.35
5b3sJ-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU B 375
ALA B 378
LEU B 408
HIS B 575
LEU B 539
 None
 1.16A 5dxeB-3p8cB:
undetectable		 5dxeB-3p8cB:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 6 GLY B 911
THR B 908
SER B 915
VAL B 912
HIS B1030
 None
CL  B1130 ( 4.7A)
None
None
None
 1.27A 5ewuB-3p8cB:
undetectable		 5ewuB-3p8cB:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL B 697
ILE B 567
LEU B 557
LEU B 603
ALA B 607
 None
 1.35A 5fctB-3p8cB:
undetectable		 5fctB-3p8cB:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 3p8c WISKOTT-ALDRICH
SYNDROME PROTEIN
FAMILY MEMBER 1
PROBABLE PROTEIN
BRICK1
ABL INTERACTOR 2
(Homo
sapiens;
Homo
sapiens;
Homo
sapiens) 		4 / 4 CYH E  43
LEU F  76
LEU D  55
ALA D  59
 None
 1.08A 5hpuA-3p8cE:
undetectable
5hpuB-3p8cE:
undetectable		 5hpuA-3p8cE:
17.46
5hpuB-3p8cE:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3p8c ABL INTERACTOR 2
NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 8 ILE F 141
GLY B  24
THR B 139
LEU B 111
 None
 0.73A 5hs1A-3p8cF:
undetectable		 5hs1A-3p8cF:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 7 LEU B 682
ARG B 705
THR B 709
LEU B 712
 None
 0.81A 5iy5A-3p8cB:
1.6
5iy5J-3p8cB:
undetectable		 5iy5A-3p8cB:
18.35
5iy5J-3p8cB:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_0
(REGULATORY PROTEIN
TETR)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 ALA B  14
LEU B 136
VAL B 119
CYH B 117
PHE B 121
 None
 1.49A 5vlmC-3p8cB:
undetectable		 5vlmC-3p8cB:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU B 682
ARG B 705
THR B 709
LEU B 712
 None
 1.07A 5x1fA-3p8cB:
1.5
5x1fJ-3p8cB:
undetectable		 5x1fA-3p8cB:
18.35
5x1fJ-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 5 ARG B 149
MET B 144
THR B 142
LEU B 143
 None
 1.33A 5x1fW-3p8cB:
undetectable		 5x1fW-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 7 LEU B 682
ARG B 705
THR B 709
LEU B 712
 None
 0.75A 5xdqN-3p8cB:
1.5
5xdqW-3p8cB:
undetectable		 5xdqN-3p8cB:
18.35
5xdqW-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 7 LEU B 682
ARG B 705
THR B 709
LEU B 712
 None
 0.97A 5xdxA-3p8cB:
3.6
5xdxJ-3p8cB:
undetectable		 5xdxA-3p8cB:
18.35
5xdxJ-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 8 LEU B 682
ARG B 705
THR B 709
LEU B 712
 None
 0.78A 5xdxN-3p8cB:
1.5
5xdxW-3p8cB:
undetectable		 5xdxN-3p8cB:
18.35
5xdxW-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU B 797
GLY B 911
LEU B 866
ILE B 859
LEU B1010
 None
 1.24A 5y2tA-3p8cB:
undetectable		 5y2tA-3p8cB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		3 / 3 LYS B 284
LEU B 280
ARG B 320
 None
 0.89A 5yw0A-3p8cB:
undetectable		 5yw0A-3p8cB:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 8 LEU B 682
ARG B 705
THR B 709
LEU B 712
 None
 0.81A 5zcoA-3p8cB:
1.4
5zcoJ-3p8cB:
undetectable		 5zcoA-3p8cB:
18.35
5zcoJ-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 7 LEU B 682
ARG B 705
THR B 709
LEU B 712
 None
 0.81A 5zcpA-3p8cB:
1.0
5zcpJ-3p8cB:
undetectable		 5zcpA-3p8cB:
18.35
5zcpJ-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 7 LEU B 682
ARG B 705
THR B 709
LEU B 712
 None
 0.83A 5zcqA-3p8cB:
3.6
5zcqJ-3p8cB:
undetectable		 5zcqA-3p8cB:
18.35
5zcqJ-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 8 LEU B 682
ARG B 705
THR B 709
LEU B 712
 None
 0.76A 5zcqN-3p8cB:
1.6
5zcqW-3p8cB:
undetectable		 5zcqN-3p8cB:
18.35
5zcqW-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		3 / 3 VAL B1119
TYR B1120
GLU B1082
 None
 0.99A 5zmqD-3p8cB:
undetectable
5zmqE-3p8cB:
undetectable		 5zmqD-3p8cB:
9.66
5zmqE-3p8cB:
3.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 11 ILE B1051
LEU B1055
LEU B 999
ILE B 910
MET B 907
 None
 1.19A 6fgcA-3p8cB:
undetectable		 6fgcA-3p8cB:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 6 THR B 783
LEU B 787
THR B 717
LEU B 842
 None
 1.23A 6mvxA-3p8cB:
undetectable
6mvxB-3p8cB:
2.9
6mvxC-3p8cB:
2.6		 6mvxA-3p8cB:
13.66
6mvxB-3p8cB:
13.66
6mvxC-3p8cB:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 5 LEU B 682
ARG B 705
THR B 709
LEU B 712
 None
 0.78A 6nmpN-3p8cB:
3.5
6nmpW-3p8cB:
undetectable		 6nmpN-3p8cB:
18.35
6nmpW-3p8cB:
4.26