SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3p8k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 3p8k HYDROLASE,
CARBON-NITROGEN
FAMILY
(Staphylococcus
aureus) 		4 / 7 SER A 136
VAL A 141
ILE A 105
ASP A  77
 CL  A 269 (-4.8A)
None
None
CL  A 269 (-3.7A)
 1.24A 2x45B-3p8kA:
undetectable		 2x45B-3p8kA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 3p8k HYDROLASE,
CARBON-NITROGEN
FAMILY
(Staphylococcus
aureus) 		4 / 7 SER A 136
VAL A 141
ILE A 105
ASP A  77
 CL  A 269 (-4.8A)
None
None
CL  A 269 (-3.7A)
 1.23A 2x45C-3p8kA:
undetectable		 2x45C-3p8kA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 3p8k HYDROLASE,
CARBON-NITROGEN
FAMILY
(Staphylococcus
aureus) 		4 / 7 SER A 136
VAL A 141
ILE A 105
ASP A  77
 CL  A 269 (-4.8A)
None
None
CL  A 269 (-3.7A)
 1.23A 3bu1A-3p8kA:
undetectable		 3bu1A-3p8kA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 3p8k HYDROLASE,
CARBON-NITROGEN
FAMILY
(Staphylococcus
aureus) 		5 / 12 ILE A 196
GLY A 197
ALA A 170
PHE A 167
ILE A 216
 None
 1.11A 3jayA-3p8kA:
undetectable		 3jayA-3p8kA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 3p8k HYDROLASE,
CARBON-NITROGEN
FAMILY
(Staphylococcus
aureus) 		5 / 12 ILE A 196
GLY A 197
ALA A 170
PHE A 167
ILE A 216
 None
 1.00A 3jb1A-3p8kA:
undetectable		 3jb1A-3p8kA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 3p8k HYDROLASE,
CARBON-NITROGEN
FAMILY
(Staphylococcus
aureus) 		5 / 9 LEU A  70
ALA A  80
VAL A  98
LEU A 104
ILE A  67
 None
 1.45A 3wsjA-3p8kA:
undetectable		 3wsjA-3p8kA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3p8k HYDROLASE,
CARBON-NITROGEN
FAMILY
(Staphylococcus
aureus) 		4 / 8 ASP A 109
ALA A  95
SER A  82
TYR A 108
 None
 1.08A 4lv9A-3p8kA:
2.4
4lv9B-3p8kA:
undetectable		 4lv9A-3p8kA:
22.29
4lv9B-3p8kA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 3p8k HYDROLASE,
CARBON-NITROGEN
FAMILY
(Staphylococcus
aureus) 		3 / 3 ARG A 176
HIS A 179
SER A 175
 PEG  A 265 (-4.3A)
None
None
 0.96A 4mjwA-3p8kA:
undetectable
4mjwB-3p8kA:
undetectable		 4mjwA-3p8kA:
19.96
4mjwB-3p8kA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 3p8k HYDROLASE,
CARBON-NITROGEN
FAMILY
(Staphylococcus
aureus) 		3 / 3 THR A  94
ASN A  85
SER A  84
 None
CL  A 271 (-3.7A)
None
 0.76A 4tvtA-3p8kA:
undetectable		 4tvtA-3p8kA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3p8k HYDROLASE,
CARBON-NITROGEN
FAMILY
(Staphylococcus
aureus) 		5 / 10 LEU A 237
GLY A 224
VAL A 223
THR A 234
VAL A 215
 None
 1.17A 4yb6A-3p8kA:
undetectable
4yb6D-3p8kA:
undetectable		 4yb6A-3p8kA:
22.22
4yb6D-3p8kA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 3p8k HYDROLASE,
CARBON-NITROGEN
FAMILY
(Staphylococcus
aureus) 		5 / 6 GLY A 202
THR A 201
SER A 200
TYR A 209
GLY A 211
 None
 1.49A 5k4pA-3p8kA:
undetectable		 5k4pA-3p8kA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 3p8k HYDROLASE,
CARBON-NITROGEN
FAMILY
(Staphylococcus
aureus) 		3 / 3 LYS A 253
GLN A 244
ASN A 248
 PEG  A 264 (-4.8A)
None
None
 0.97A 5l2tA-3p8kA:
undetectable		 5l2tA-3p8kA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3p8k HYDROLASE,
CARBON-NITROGEN
FAMILY
(Staphylococcus
aureus) 		5 / 12 ILE A 196
ILE A 165
VAL A 215
ASN A 219
GLU A 241
 None
 1.01A 5lg3E-3p8kA:
undetectable		 5lg3E-3p8kA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA302_0
(AMIDASE)		 3p8k HYDROLASE,
CARBON-NITROGEN
FAMILY
(Staphylococcus
aureus) 		5 / 9 GLU A  41
TYR A  47
LYS A 110
GLU A 119
TYR A 147
 None
None
None
None
PEG  A 265 (-4.5A)
 1.05A 5ny7A-3p8kA:
32.6		 5ny7A-3p8kA:
28.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 3p8k HYDROLASE,
CARBON-NITROGEN
FAMILY
(Staphylococcus
aureus) 		4 / 8 HIS A   0
GLY A  -2
LEU A 135
GLY A 138
 GOL  A 268 (-4.2A)
None
CL  A 269 (-4.1A)
None
 0.87A 6mdqA-3p8kA:
undetectable		 6mdqA-3p8kA:
14.60