SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3p8r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 3p8r GERANYLTRANSTRANSFER
ASE
(Vibrio
cholerae) 		4 / 8 ALA A 286
LEU A 265
LEU A 264
LEU A 272
 None
 0.77A 1ereE-3p8rA:
3.2		 1ereE-3p8rA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 3p8r GERANYLTRANSTRANSFER
ASE
(Vibrio
cholerae) 		4 / 8 ALA A 286
LEU A 265
LEU A 264
LEU A 272
 None
 0.79A 1ereF-3p8rA:
undetectable		 1ereF-3p8rA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 3p8r GERANYLTRANSTRANSFER
ASE
(Vibrio
cholerae) 		4 / 6 ALA A 194
SER A   7
TRP A  19
LEU A 128
 None
 1.23A 1gahA-3p8rA:
undetectable		 1gahA-3p8rA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 3p8r GERANYLTRANSTRANSFER
ASE
(Vibrio
cholerae) 		5 / 12 GLY A  37
VAL A  71
ARG A  46
HIS A  75
ILE A 122
 None
 1.17A 2b25B-3p8rA:
undetectable		 2b25B-3p8rA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 3p8r GERANYLTRANSTRANSFER
ASE
(Vibrio
cholerae) 		6 / 12 GLY A 132
GLY A  54
GLY A 191
GLY A 196
THR A  53
LEU A  49
 None
 1.50A 3elwA-3p8rA:
undetectable		 3elwA-3p8rA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 3p8r GERANYLTRANSTRANSFER
ASE
(Vibrio
cholerae) 		3 / 3 SER A 147
MET A 152
ASP A 207
 None
 0.97A 4mm4B-3p8rA:
undetectable		 4mm4B-3p8rA:
22.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 3p8r GERANYLTRANSTRANSFER
ASE
(Vibrio
cholerae) 		5 / 8 SER A  78
LEU A  79
ASP A  82
MET A 152
GLN A 156
 None
 0.93A 4umjA-3p8rA:
34.8		 4umjA-3p8rA:
52.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 3p8r GERANYLTRANSTRANSFER
ASE
(Vibrio
cholerae) 		4 / 8 SER A  78
LEU A  79
MET A 152
LYS A 179
 None
 0.85A 4umjA-3p8rA:
34.8		 4umjA-3p8rA:
52.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 3p8r GERANYLTRANSTRANSFER
ASE
(Vibrio
cholerae) 		6 / 9 SER A  78
LEU A  79
ASP A  82
MET A 152
GLN A 156
THR A 180
 None
 0.83A 4umjB-3p8rA:
34.8		 4umjB-3p8rA:
52.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 3p8r GERANYLTRANSTRANSFER
ASE
(Vibrio
cholerae) 		5 / 9 SER A  78
LEU A  79
MET A 152
LYS A 179
THR A 180
 None
 0.90A 4umjB-3p8rA:
34.8		 4umjB-3p8rA:
52.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 3p8r GERANYLTRANSTRANSFER
ASE
(Vibrio
cholerae) 		4 / 6 HIS A  75
GLY A  41
GLU A  72
ARG A  44
 None
 0.82A 4zbqA-3p8rA:
3.8		 4zbqA-3p8rA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 3p8r GERANYLTRANSTRANSFER
ASE
(Vibrio
cholerae) 		4 / 6 HIS A  75
GLY A  42
GLU A  72
ARG A  44
 None
 1.13A 4zbqA-3p8rA:
3.8		 4zbqA-3p8rA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3p8r GERANYLTRANSTRANSFER
ASE
(Vibrio
cholerae) 		4 / 7 ALA A 274
ARG A 200
GLY A 199
GLU A 197
 None
 0.96A 5btdA-3p8rA:
undetectable
5btdC-3p8rA:
undetectable
5btdD-3p8rA:
undetectable		 5btdA-3p8rA:
20.63
5btdC-3p8rA:
20.63
5btdD-3p8rA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3p8r GERANYLTRANSTRANSFER
ASE
(Vibrio
cholerae) 		5 / 9 LEU A 190
VAL A  50
VAL A  71
ILE A 122
ASP A  65
 None
 1.24A 5yf9X-3p8rA:
undetectable		 5yf9X-3p8rA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3p8r GERANYLTRANSTRANSFER
ASE
(Vibrio
cholerae) 		5 / 12 ILE A 188
ALA A 187
LEU A  49
ILE A 275
LEU A 203
 None
 0.95A 6a5zL-3p8rA:
undetectable		 6a5zL-3p8rA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3p8r GERANYLTRANSTRANSFER
ASE
(Vibrio
cholerae) 		4 / 8 HIS A  -2
HIS A 262
GLU A 291
GLU A 283
 None
 1.18A 6mn4A-3p8rA:
undetectable		 6mn4A-3p8rA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3p8r GERANYLTRANSTRANSFER
ASE
(Vibrio
cholerae) 		4 / 7 HIS A  -2
HIS A 262
GLU A 291
GLU A 283
 None
 1.12A 6mn4F-3p8rA:
undetectable		 6mn4F-3p8rA:
24.60