SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3p8t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		3 / 3 GLU A 101
HIS A 110
ASP A  52
 None
 0.81A 1i9gA-3p8tA:
undetectable		 1i9gA-3p8tA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 8 ILE A  77
GLY A 219
SER A  75
ARG A  99
 None
 0.86A 1mrjA-3p8tA:
undetectable		 1mrjA-3p8tA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		5 / 9 PHE A  34
LEU A 117
GLY A 262
VAL A 129
ILE A 121
 None
 1.29A 2a1oB-3p8tA:
undetectable		 2a1oB-3p8tA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 7 TRP A 202
LYS A 232
PRO A  51
ALA A 236
 None
 1.35A 2ejgB-3p8tA:
4.6		 2ejgB-3p8tA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 7 ILE A  45
GLN A  81
LEU A 255
LEU A 247
 None
 0.92A 2qqcB-3p8tA:
undetectable
2qqcC-3p8tA:
undetectable		 2qqcB-3p8tA:
17.25
2qqcC-3p8tA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 7 LEU A 255
LEU A 247
ILE A  45
GLN A  81
 None
 0.94A 2qqcA-3p8tA:
undetectable
2qqcF-3p8tA:
0.2		 2qqcA-3p8tA:
11.34
2qqcF-3p8tA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 7 LEU A 255
LEU A 247
ILE A  45
GLN A  81
 None
 0.94A 2qqcG-3p8tA:
undetectable
2qqcJ-3p8tA:
0.3		 2qqcG-3p8tA:
11.34
2qqcJ-3p8tA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 7 LEU A 255
LEU A 247
ILE A  45
GLN A  81
 None
 0.91A 2qqcI-3p8tA:
undetectable
2qqcL-3p8tA:
undetectable		 2qqcI-3p8tA:
11.34
2qqcL-3p8tA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 8 ILE A  45
GLN A  81
LEU A 255
LEU A 247
 None
 0.90A 2qqcH-3p8tA:
0.1
2qqcK-3p8tA:
undetectable		 2qqcH-3p8tA:
17.25
2qqcK-3p8tA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_1
(PHOSPHOLIPASE A2)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 5 VAL A 287
PHE A 284
ARG A 103
ARG A 109
 None
 1.39A 3bjwE-3p8tA:
undetectable		 3bjwE-3p8tA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 6 VAL A 287
PHE A 284
ARG A 103
ARG A 109
 None
 1.23A 3bjwF-3p8tA:
undetectable		 3bjwF-3p8tA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		3 / 3 TYR A 194
ASP A 118
HIS A  74
 None
 0.87A 3e23A-3p8tA:
undetectable		 3e23A-3p8tA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_B_ACTB600_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 5 ARG A  99
HIS A 110
ALA A  54
GLU A 215
 None
 1.32A 3mbgB-3p8tA:
0.0
3mbgC-3p8tA:
0.0		 3mbgB-3p8tA:
16.78
3mbgC-3p8tA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC600_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 5 GLU A 215
ARG A  99
HIS A 110
ALA A  54
 None
 1.29A 3mbgB-3p8tA:
0.0
3mbgC-3p8tA:
0.0		 3mbgB-3p8tA:
16.78
3mbgC-3p8tA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 8 GLU A 145
TYR A 211
PHE A 271
ARG A 142
 None
 0.99A 3mjrD-3p8tA:
undetectable		 3mjrD-3p8tA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_A_ACRA701_1
(ALPHA-GLUCOSIDASE)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		5 / 12 ASP A 173
ILE A 208
ILE A 186
ARG A 191
ASP A  52
 None
 1.28A 3phaA-3p8tA:
undetectable		 3phaA-3p8tA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_A_ACRA701_1
(ALPHA-GLUCOSIDASE)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		5 / 12 ASP A 173
ILE A 208
ILE A 186
ASP A 206
ASP A  52
 None
 1.45A 3phaA-3p8tA:
undetectable		 3phaA-3p8tA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		6 / 12 ASP A 173
ILE A 208
ILE A 186
ASP A 206
ARG A 191
ASP A  52
 None
 1.48A 3phaB-3p8tA:
undetectable		 3phaB-3p8tA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB664_1
(ALPHA-GLUCOSIDASE)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		5 / 12 ASP A 173
ILE A 208
ILE A 186
ARG A 191
ASP A  52
 None
 1.29A 3pocB-3p8tA:
undetectable		 3pocB-3p8tA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 7 ILE A 263
GLY A 264
SER A 217
LEU A 209
 None
 0.83A 3v7pA-3p8tA:
undetectable		 3v7pA-3p8tA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		5 / 12 LEU A  94
ILE A  21
VAL A 265
LEU A 268
VAL A 216
 None
 1.21A 3w68C-3p8tA:
undetectable		 3w68C-3p8tA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 7 ASP A 195
ASP A  52
ASP A 118
GLU A 192
 None
 1.11A 4feuB-3p8tA:
2.0		 4feuB-3p8tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 7 ASP A 195
ASP A  52
GLU A 215
ASP A  47
 None
 1.16A 4feuB-3p8tA:
2.0		 4feuB-3p8tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 8 ASP A 195
ASP A  52
ASP A 118
GLU A 192
 None
 1.12A 4feuD-3p8tA:
1.9		 4feuD-3p8tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 8 ASP A 195
ASP A  52
ASP A 118
GLU A 192
 None
 1.05A 4feuF-3p8tA:
undetectable		 4feuF-3p8tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 8 ASP A 195
ASP A  52
GLU A 215
ASP A  47
 None
 1.18A 4feuF-3p8tA:
undetectable		 4feuF-3p8tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 7 ASP A 195
ASP A  52
ASP A 118
GLU A 192
 None
 1.12A 4fevB-3p8tA:
0.5		 4fevB-3p8tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 7 ASP A 195
ASP A  52
ASP A 118
GLU A 192
 None
 1.11A 4fevD-3p8tA:
undetectable		 4fevD-3p8tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 7 ASP A 195
ASP A  52
GLU A 215
ASP A  47
 None
 1.18A 4fevD-3p8tA:
undetectable		 4fevD-3p8tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 7 ASP A 195
ASP A  52
ASP A 118
GLU A 192
 None
 1.10A 4fevF-3p8tA:
1.8		 4fevF-3p8tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 7 ASP A 195
ASP A  52
GLU A 215
ASP A  47
 None
 1.17A 4fevF-3p8tA:
1.8		 4fevF-3p8tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 7 ASP A 195
ASP A  52
ASP A 118
GLU A 192
 None
 1.12A 4fewB-3p8tA:
undetectable		 4fewB-3p8tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 8 ASP A 195
ASP A  52
ASP A 118
GLU A 192
 None
 1.14A 4fewD-3p8tA:
1.9		 4fewD-3p8tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 8 ASP A 195
ASP A  52
GLU A 215
ASP A  47
 None
 1.18A 4fewD-3p8tA:
1.9		 4fewD-3p8tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 8 ASP A 195
ASP A  52
ASP A 118
GLU A 192
 None
 1.15A 4fewF-3p8tA:
undetectable		 4fewF-3p8tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 8 ASP A 195
ASP A  52
GLU A 215
ASP A  47
 None
 1.18A 4fewF-3p8tA:
undetectable		 4fewF-3p8tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 7 ASP A 195
ASP A  52
ASP A 118
GLU A 192
 None
 1.14A 4fexB-3p8tA:
undetectable		 4fexB-3p8tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 7 ASP A 195
ASP A  52
GLU A 215
ASP A  47
 None
 1.22A 4fexB-3p8tA:
undetectable		 4fexB-3p8tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		5 / 12 ARG A 131
GLU A 134
ARG A  32
VAL A 187
VAL A 160
 None
 1.47A 4ffwA-3p8tA:
undetectable		 4ffwA-3p8tA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 8 ASP A 195
ASP A  52
ASP A 118
GLU A 192
 None
 1.11A 4gkhB-3p8tA:
1.9		 4gkhB-3p8tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 8 ASP A 195
ASP A  52
ASP A 118
GLU A 192
 None
 1.13A 4gkhD-3p8tA:
0.7		 4gkhD-3p8tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 8 ASP A 195
ASP A  52
ASP A 118
GLU A 192
 None
 1.14A 4gkhF-3p8tA:
1.8		 4gkhF-3p8tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 8 ASP A 195
ASP A  52
GLU A 215
ASP A  47
 None
 1.18A 4gkhF-3p8tA:
1.8		 4gkhF-3p8tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 7 ASP A 195
ASP A  52
ASP A 118
GLU A 192
 None
 1.13A 4gkhG-3p8tA:
1.9		 4gkhG-3p8tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 7 ASP A 195
ASP A  52
GLU A 215
ASP A  47
 None
 1.17A 4gkhG-3p8tA:
1.9		 4gkhG-3p8tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 6 ASP A 195
ASP A  52
ASP A 118
GLU A 192
 None
 1.13A 4gkhJ-3p8tA:
1.9		 4gkhJ-3p8tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 8 ASP A 195
ASP A  52
ASP A 118
GLU A 192
 None
 1.10A 4gkhC-3p8tA:
undetectable
4gkhK-3p8tA:
1.8		 4gkhC-3p8tA:
20.13
4gkhK-3p8tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 8 ASP A 195
ASP A  52
ASP A 118
GLU A 192
 None
 1.15A 4gkiA-3p8tA:
1.9		 4gkiA-3p8tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 8 ASP A 195
ASP A  52
GLU A 215
ASP A  47
 None
 1.18A 4gkiA-3p8tA:
1.9		 4gkiA-3p8tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 8 ASP A 195
ASP A  52
ASP A 118
GLU A 192
 None
 1.12A 4gkiC-3p8tA:
1.9		 4gkiC-3p8tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 8 ASP A 195
ASP A  52
ASP A 118
GLU A 192
 None
 1.12A 4gkiE-3p8tA:
1.8
4gkiG-3p8tA:
1.9		 4gkiE-3p8tA:
20.13
4gkiG-3p8tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 8 ASP A 195
ASP A  52
GLU A 215
ASP A  47
 None
 1.15A 4gkiE-3p8tA:
1.8
4gkiG-3p8tA:
1.9		 4gkiE-3p8tA:
20.13
4gkiG-3p8tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 8 LEU A  94
LEU A 117
VAL A 265
ILE A  21
 None
 0.94A 4oj4A-3p8tA:
undetectable		 4oj4A-3p8tA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 7 GLU A 120
ARG A 191
GLY A 219
GLY A 260
 None
 0.77A 4rdxA-3p8tA:
15.3		 4rdxA-3p8tA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		3 / 3 GLU A 101
HIS A 110
ASP A  52
 None
 0.84A 5c0oG-3p8tA:
undetectable		 5c0oG-3p8tA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		5 / 12 ILE A  58
GLU A  56
GLY A  55
ASN A  97
THR A  46
 None
 1.41A 5fhzD-3p8tA:
undetectable		 5fhzD-3p8tA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		4 / 8 GLU A 227
VAL A 230
GLY A 253
LEU A 255
 None
 0.82A 5sxtB-3p8tA:
undetectable		 5sxtB-3p8tA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		5 / 10 ARG A  99
GLU A 101
HIS A 110
GLU A 215
ARG A 109
 None
 1.19A 6bniA-3p8tA:
28.0		 6bniA-3p8tA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		5 / 10 ARG A  99
GLU A 101
PHE A 114
ARG A 267
ILE A 278
 None
 1.13A 6bniA-3p8tA:
28.0		 6bniA-3p8tA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		8 / 10 ASN A  97
ARG A  99
GLU A 101
HIS A 110
PHE A 114
GLU A 215
GLY A 264
ILE A 278
 None
 0.75A 6bniA-3p8tA:
28.0		 6bniA-3p8tA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		5 / 10 ARG A  99
GLU A 101
HIS A 110
GLU A 215
ARG A 109
 None
 1.17A 6bniB-3p8tA:
27.9		 6bniB-3p8tA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		5 / 10 ARG A  99
GLU A 101
PHE A 114
ARG A 267
ILE A 278
 None
 1.07A 6bniB-3p8tA:
27.9		 6bniB-3p8tA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		8 / 10 ASN A  97
ARG A  99
GLU A 101
HIS A 110
PHE A 114
GLU A 215
GLY A 264
ILE A 278
 None
 0.69A 6bniB-3p8tA:
27.9		 6bniB-3p8tA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		5 / 12 ASP A 173
ILE A 208
ILE A 186
ARG A 191
ASP A  52
 None
 1.28A 6ca1A-3p8tA:
undetectable		 6ca1A-3p8tA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		5 / 12 ASP A 173
ILE A 208
ILE A 186
ASP A 206
ASP A  52
 None
 1.43A 6ca1A-3p8tA:
undetectable		 6ca1A-3p8tA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		5 / 12 ASP A 173
ILE A 208
ILE A 186
ARG A 191
ASP A  52
 None
 1.30A 6ca1B-3p8tA:
undetectable		 6ca1B-3p8tA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		5 / 12 ASP A 173
ILE A 208
ILE A 186
ASP A 206
ASP A  52
 None
 1.44A 6ca1B-3p8tA:
undetectable		 6ca1B-3p8tA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		5 / 12 ASP A 173
ILE A 208
ILE A 186
ARG A 191
ASP A  52
 None
 1.26A 6ca3B-3p8tA:
undetectable		 6ca3B-3p8tA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		5 / 12 ASP A 173
ILE A 208
ILE A 186
ASP A 206
ASP A  52
 None
 1.39A 6ca3B-3p8tA:
undetectable		 6ca3B-3p8tA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN
(Pyrococcus
abyssi) 		3 / 3 ARG A  99
HIS A 110
ARG A 267
 None
 1.16A 6dwdD-3p8tA:
undetectable		 6dwdD-3p8tA:
20.83