SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3p91'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3p91 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Entamoeba
histolytica) 		5 / 12 ILE A  80
VAL A 101
LEU A  92
VAL A  18
ILE A  54
 None
 1.00A 1epbA-3p91A:
undetectable		 1epbA-3p91A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3p91 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Entamoeba
histolytica) 		5 / 12 PHE A  14
LEU A  52
VAL A  39
PHE A  30
VAL A  17
 None
 1.34A 1q23B-3p91A:
undetectable		 1q23B-3p91A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3p91 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Entamoeba
histolytica) 		5 / 12 PHE A  14
LEU A  52
VAL A  39
PHE A  30
VAL A  17
 None
 1.37A 1q23C-3p91A:
undetectable		 1q23C-3p91A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3p91 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Entamoeba
histolytica) 		5 / 10 PHE A  14
LEU A  52
VAL A  39
PHE A  30
VAL A  17
 None
 1.36A 1q23E-3p91A:
undetectable		 1q23E-3p91A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3p91 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Entamoeba
histolytica) 		5 / 11 PHE A  14
LEU A  52
VAL A  39
PHE A  30
VAL A  17
 None
 1.35A 1q23I-3p91A:
undetectable		 1q23I-3p91A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3p91 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Entamoeba
histolytica) 		5 / 10 PHE A  14
LEU A  52
VAL A  39
PHE A  30
VAL A  17
 None
 1.31A 1q23K-3p91A:
undetectable		 1q23K-3p91A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3p91 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Entamoeba
histolytica) 		3 / 3 ALA A 216
THR A 149
PHE A 248
 None
 0.74A 2c6nB-3p91A:
undetectable		 2c6nB-3p91A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_B_RBVB601_1
(RNA POLYMERASE)		 3p91 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Entamoeba
histolytica) 		5 / 9 ASP A  31
THR A  28
ASN A  29
GLY A  71
LEU A 117
 None
 1.33A 3sfuB-3p91A:
undetectable		 3sfuB-3p91A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3p91 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Entamoeba
histolytica) 		5 / 10 PHE A  14
LEU A  52
VAL A  39
PHE A  30
VAL A  17
 None
 1.33A 3u9fI-3p91A:
undetectable		 3u9fI-3p91A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3p91 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Entamoeba
histolytica) 		5 / 12 PHE A  14
LEU A  52
VAL A  39
PHE A  30
VAL A  17
 None
 1.28A 3u9fJ-3p91A:
undetectable
3u9fK-3p91A:
undetectable		 3u9fJ-3p91A:
22.85
3u9fK-3p91A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3p91 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Entamoeba
histolytica) 		5 / 10 PHE A  14
LEU A  52
VAL A  39
PHE A  30
VAL A  17
 None
 1.28A 3u9fR-3p91A:
undetectable		 3u9fR-3p91A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 3p91 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Entamoeba
histolytica) 		5 / 9 PHE A   4
ILE A  68
LEU A 119
GLY A  71
ASN A  29
 None
 1.37A 4eb4C-3p91A:
undetectable		 4eb4C-3p91A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 3p91 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Entamoeba
histolytica) 		4 / 5 PHE A   4
ILE A  37
GLY A  36
THR A  56
 None
 0.99A 4ejjC-3p91A:
undetectable		 4ejjC-3p91A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3p91 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Entamoeba
histolytica) 		5 / 11 ILE A  37
ALA A   6
LEU A  90
PHE A  14
LEU A  77
 None
 1.25A 4i1nA-3p91A:
undetectable		 4i1nA-3p91A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3p91 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Entamoeba
histolytica) 		5 / 12 ILE A  37
ALA A   6
LEU A  90
PHE A  14
LEU A  77
 None
 1.20A 4rgcA-3p91A:
undetectable		 4rgcA-3p91A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3p91 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Entamoeba
histolytica) 		4 / 6 GLY A 241
LEU A 221
PHE A  59
PHE A  62
 None
 1.03A 6h7lA-3p91A:
undetectable		 6h7lA-3p91A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3p91 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Entamoeba
histolytica) 		4 / 6 GLY A 241
LEU A 221
PHE A  59
PHE A  62
 None
 1.02A 6h7lB-3p91A:
undetectable		 6h7lB-3p91A:
16.28