SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3p9n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 3p9n POSSIBLE
METHYLTRANSFERASE
(METHYLASE)
(Mycobacterium
tuberculosis) 		4 / 7 LEU A  89
LEU A  91
SER A  92
VAL A  47
 None
 0.90A 1dvxB-3p9nA:
undetectable		 1dvxB-3p9nA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_1
(HIV-II PROTEASE)		 3p9n POSSIBLE
METHYLTRANSFERASE
(METHYLASE)
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  93
ALA A  94
ILE A  82
GLY A  58
ILE A  86
 None
 0.86A 1hshA-3p9nA:
undetectable		 1hshA-3p9nA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3p9n POSSIBLE
METHYLTRANSFERASE
(METHYLASE)
(Mycobacterium
tuberculosis) 		4 / 6 PHE A  33
ASN A  34
ILE A   5
GLY A   6
 None
 1.08A 1oniA-3p9nA:
undetectable
1oniB-3p9nA:
undetectable		 1oniA-3p9nA:
25.26
1oniB-3p9nA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3p9n POSSIBLE
METHYLTRANSFERASE
(METHYLASE)
(Mycobacterium
tuberculosis) 		4 / 6 PHE A  33
ASN A  34
ILE A   5
GLY A   6
 None
 1.09A 1oniD-3p9nA:
undetectable
1oniF-3p9nA:
undetectable		 1oniD-3p9nA:
25.26
1oniF-3p9nA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 3p9n POSSIBLE
METHYLTRANSFERASE
(METHYLASE)
(Mycobacterium
tuberculosis) 		4 / 7 LEU A  89
LEU A  91
SER A  92
VAL A  47
 None
 0.90A 1tyrB-3p9nA:
undetectable		 1tyrB-3p9nA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_B_SALB503_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 3p9n POSSIBLE
METHYLTRANSFERASE
(METHYLASE)
(Mycobacterium
tuberculosis) 		5 / 10 ALA A  66
LEU A  42
PHE A  33
PHE A  71
LEU A 115
 None
 1.14A 1y7iB-3p9nA:
3.3		 1y7iB-3p9nA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3p9n POSSIBLE
METHYLTRANSFERASE
(METHYLASE)
(Mycobacterium
tuberculosis) 		3 / 3 ALA A  56
THR A   2
PHE A  33
 None
 0.66A 2c6nB-3p9nA:
undetectable		 2c6nB-3p9nA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 3p9n POSSIBLE
METHYLTRANSFERASE
(METHYLASE)
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  53
LEU A  57
ASP A  75
ASP A 119
PRO A 121
 None
 1.14A 2f8lA-3p9nA:
14.5		 2f8lA-3p9nA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 3p9n POSSIBLE
METHYLTRANSFERASE
(METHYLASE)
(Mycobacterium
tuberculosis) 		4 / 8 VAL A 149
VAL A 147
PHE A  33
ALA A  61
 None
 1.06A 2ij7C-3p9nA:
undetectable		 2ij7C-3p9nA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3p9n POSSIBLE
METHYLTRANSFERASE
(METHYLASE)
(Mycobacterium
tuberculosis) 		5 / 12 ASP A  49
LEU A  50
GLY A  53
LEU A  57
ASP A  75
 None
 0.70A 2nxeA-3p9nA:
16.5		 2nxeA-3p9nA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 3p9n POSSIBLE
METHYLTRANSFERASE
(METHYLASE)
(Mycobacterium
tuberculosis) 		5 / 10 ALA A  61
LEU A 178
LEU A 117
LEU A  32
ARG A  29
 None
 1.08A 2xn6A-3p9nA:
undetectable
2xn6B-3p9nA:
undetectable		 2xn6A-3p9nA:
19.32
2xn6B-3p9nA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FGR_A_ACTA22_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2 28 KDA FORM)		 3p9n POSSIBLE
METHYLTRANSFERASE
(METHYLASE)
(Mycobacterium
tuberculosis) 		4 / 4 TRP A 168
ARG A 166
GLU A 182
LEU A 184
 None
 1.48A 3fgrA-3p9nA:
0.0		 3fgrA-3p9nA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_2
(PROTEASE)		 3p9n POSSIBLE
METHYLTRANSFERASE
(METHYLASE)
(Mycobacterium
tuberculosis) 		5 / 11 GLY A  93
ALA A  94
ILE A  82
GLY A  58
ILE A  86
 None
 0.87A 3s45B-3p9nA:
undetectable		 3s45B-3p9nA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 3p9n POSSIBLE
METHYLTRANSFERASE
(METHYLASE)
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  89
VAL A  69
LEU A  57
GLY A  58
ILE A   4
 None
 1.29A 4o5fA-3p9nA:
2.4
4o5fB-3p9nA:
2.2		 4o5fA-3p9nA:
22.86
4o5fB-3p9nA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 3p9n POSSIBLE
METHYLTRANSFERASE
(METHYLASE)
(Mycobacterium
tuberculosis) 		5 / 9 ALA A  61
LEU A 178
LEU A 117
LEU A  32
ARG A  29
 None
 1.27A 4x30A-3p9nA:
undetectable		 4x30A-3p9nA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 3p9n POSSIBLE
METHYLTRANSFERASE
(METHYLASE)
(Mycobacterium
tuberculosis) 		3 / 3 LYS A  25
ARG A 171
VAL A 172
 None
 0.70A 4x3uA-3p9nA:
undetectable
4x3uB-3p9nA:
undetectable		 4x3uA-3p9nA:
16.02
4x3uB-3p9nA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 3p9n POSSIBLE
METHYLTRANSFERASE
(METHYLASE)
(Mycobacterium
tuberculosis) 		4 / 6 LEU A  89
LEU A  91
SER A  92
VAL A  47
 None
 0.94A 5a6iA-3p9nA:
undetectable		 5a6iA-3p9nA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 3p9n POSSIBLE
METHYLTRANSFERASE
(METHYLASE)
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  89
VAL A  69
LEU A  57
GLY A  58
ILE A   4
 None
 1.24A 5b8hA-3p9nA:
2.7
5b8hB-3p9nA:
2.4		 5b8hA-3p9nA:
23.08
5b8hB-3p9nA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 3p9n POSSIBLE
METHYLTRANSFERASE
(METHYLASE)
(Mycobacterium
tuberculosis) 		4 / 7 GLY A  53
SER A  54
GLU A  73
ASP A 119
 None
 0.71A 5ergB-3p9nA:
15.0		 5ergB-3p9nA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3p9n POSSIBLE
METHYLTRANSFERASE
(METHYLASE)
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 119
PRO A 121
GLY A  53
GLU A  73
SER A  74
 None
 0.78A 5hfjA-3p9nA:
3.2		 5hfjA-3p9nA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3p9n POSSIBLE
METHYLTRANSFERASE
(METHYLASE)
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 119
PRO A 121
GLY A  53
GLU A  73
SER A  74
 None
 0.85A 5hfjD-3p9nA:
3.5		 5hfjD-3p9nA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3p9n POSSIBLE
METHYLTRANSFERASE
(METHYLASE)
(Mycobacterium
tuberculosis) 		5 / 12 PRO A 121
GLY A  53
SER A  54
GLU A  73
SER A  74
 None
 0.78A 5hfjD-3p9nA:
3.5		 5hfjD-3p9nA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3p9n POSSIBLE
METHYLTRANSFERASE
(METHYLASE)
(Mycobacterium
tuberculosis) 		6 / 12 ASP A 119
PRO A  17
GLY A  53
SER A  54
GLU A  73
SER A  74
 None
 1.18A 5hfjE-3p9nA:
3.3		 5hfjE-3p9nA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3p9n POSSIBLE
METHYLTRANSFERASE
(METHYLASE)
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 119
PRO A 121
GLY A  53
GLU A  73
SER A  74
 None
 0.78A 5hfjF-3p9nA:
3.4		 5hfjF-3p9nA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3p9n POSSIBLE
METHYLTRANSFERASE
(METHYLASE)
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  82
GLY A  53
VAL A 101
ALA A  79
ALA A  83
 None
 1.16A 5n0oB-3p9nA:
undetectable		 5n0oB-3p9nA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_1
(PROTEASE)		 3p9n POSSIBLE
METHYLTRANSFERASE
(METHYLASE)
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  93
ALA A  94
ILE A  82
GLY A  58
ILE A  86
 None
 0.91A 5t8hA-3p9nA:
undetectable		 5t8hA-3p9nA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 3p9n POSSIBLE
METHYLTRANSFERASE
(METHYLASE)
(Mycobacterium
tuberculosis) 		5 / 12 ASP A  49
LEU A  57
GLY A  58
THR A   2
ALA A 118
 None
 1.08A 5x66F-3p9nA:
undetectable		 5x66F-3p9nA:
21.62