SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3p9w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1E7W_A_MTXA301_1 (PTERIDINE REDUCTASE)	3p9w	HUMAN VEGF (Homo sapiens)	5 / 12	PRO B 41 LEU B 108 LEU B 18 LEU B 82 ASP B 86	PRO B 41 ( 1.1A) LEU B 108 ( 0.6A) LEU B 18 ( 0.5A) LEU B 82 ( 0.5A) ASP B 86 ( 0.5A)	1.26A	1e7wA-3p9wB: undetectable	1e7wA-3p9wB: 19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D9L_A_ACTA501_0 (CTD-PEPTIDE RNA-BINDING PROTEIN 16)	3p9w	HUMAN VEGF (Homo sapiens)	4 / 5	ILE B 34 PRO B 52 TYR B 52 TYR B 33	ILE B 34 ( 0.6A) PRO B 52 ( 1.1A) TYR B 52 ( 1.3A) TYR B 33 ( 1.3A)	0.77A	3d9lA-3p9wB: undetectable 3d9lY-3p9wB: undetectable	3d9lA-3p9wB: 16.90 3d9lY-3p9wB: 8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UUN_A_ACTA309_0 (GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN)	3p9w	HUMAN VEGF (Homo sapiens)	4 / 4	LEU B 4 GLY B 104 SER B 103 SER B 102	LEU B 4 ( 0.6A) GLY B 104 ( 0.0A) SER B 103 ( 0.0A) SER B 102 ( 0.0A)	1.18A	5uunA-3p9wB: undetectable	5uunA-3p9wB: 20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C2M_A_SUEA1202_1 (NS3 PROTEASE)	3p9w	HUMAN VEGF (Homo sapiens)	5 / 9	ARG B 38 ALA B 84 VAL B 111 SER B 112 ASP B 86	ARG B 38 ( 0.6A) ALA B 84 ( 0.0A) VAL B 111 ( 0.6A) SER B 112 ( 0.0A) ASP B 86 ( 0.5A)	1.47A	6c2mA-3p9wB: undetectable	6c2mA-3p9wB: 23.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6CJK_B_ACTB302_0 (IMMUNOGLOBULIN FAB HEAVY CHAIN)	3p9w	HUMAN VEGF (Homo sapiens)	3 / 3	TYR B 59 GLY B 65 THR B 68	TYR B 59 ( 1.3A) GLY B 65 ( 0.0A) THR B 68 ( 0.8A)	0.12A	6cjkB-3p9wB: 18.7	6cjkB-3p9wB: 37.63

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1E7W_A_MTXA301_1","PTERIDINE REDUCTASE","3p9w","HUMAN VEGF","Homo sapiens",5,"PRO B  41;LEU B 108;LEU B  18;LEU B  82;ASP B  86","PRO B  41 ( 1.1A);LEU B 108 ( 0.6A);LEU B  18 ( 0.5A);LEU B  82 ( 0.5A);ASP B  86 ( 0.5A)","1.26A","1e7wA-3p9wB:undetectable","1e7wA-3p9wB:19.51"],["3D9L_A_ACTA501_0","CTD-PEPTIDE;RNA-BINDING PROTEIN 16","3p9w","HUMAN VEGF","Homo sapiens",4,"ILE B  34;PRO B  52;TYR B  52;TYR B  33","ILE B  34 ( 0.6A);PRO B  52 ( 1.1A);TYR B  52 ( 1.3A);TYR B  33 ( 1.3A)","0.77A","3d9lA-3p9wB:undetectable;3d9lY-3p9wB:undetectable","3d9lA-3p9wB:16.90;3d9lY-3p9wB:8.13"],["5UUN_A_ACTA309_0","GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN","3p9w","HUMAN VEGF","Homo sapiens",4,"LEU B   4;GLY B 104;SER B 103;SER B 102","LEU B   4 ( 0.6A);GLY B 104 ( 0.0A);SER B 103 ( 0.0A);SER B 102 ( 0.0A)","1.18A","5uunA-3p9wB:undetectable","5uunA-3p9wB:20.16"],["6C2M_A_SUEA1202_1","NS3 PROTEASE","3p9w","HUMAN VEGF","Homo sapiens",5,"ARG B  38;ALA B  84;VAL B 111;SER B 112;ASP B  86","ARG B  38 ( 0.6A);ALA B  84 ( 0.0A);VAL B 111 ( 0.6A);SER B 112 ( 0.0A);ASP B  86 ( 0.5A)","1.47A","6c2mA-3p9wB:undetectable","6c2mA-3p9wB:23.73"],["6CJK_B_ACTB302_0","IMMUNOGLOBULIN FAB HEAVY CHAIN","3p9w","HUMAN VEGF","Homo sapiens",3,"TYR B  59;GLY B  65;THR B  68","TYR B  59 ( 1.3A);GLY B  65 ( 0.0A);THR B  68 ( 0.8A)","0.12A","6cjkB-3p9wB:18.7","6cjkB-3p9wB:37.63"]]