SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3p9z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 3p9z UROPORPHYRINOGEN III
COSYNTHASE (HEMD)
(Helicobacter
pylori) 		3 / 3 LEU A  49
LEU A  53
SER A  56
 None
 0.69A 1tlmA-3p9zA:
undetectable		 1tlmA-3p9zA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3p9z UROPORPHYRINOGEN III
COSYNTHASE (HEMD)
(Helicobacter
pylori) 		4 / 8 ALA A 206
ILE A 188
ILE A 186
HIS A   8
 None
 0.89A 2zm8A-3p9zA:
undetectable		 2zm8A-3p9zA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3p9z UROPORPHYRINOGEN III
COSYNTHASE (HEMD)
(Helicobacter
pylori) 		4 / 8 ALA A 206
ILE A 188
ILE A 186
HIS A 169
 None
 0.79A 2zm8A-3p9zA:
undetectable		 2zm8A-3p9zA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3p9z UROPORPHYRINOGEN III
COSYNTHASE (HEMD)
(Helicobacter
pylori) 		4 / 8 ALA A 206
ILE A 188
ILE A 186
HIS A   8
 None
 0.89A 2zmaA-3p9zA:
undetectable		 2zmaA-3p9zA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3p9z UROPORPHYRINOGEN III
COSYNTHASE (HEMD)
(Helicobacter
pylori) 		4 / 8 ALA A 206
ILE A 188
ILE A 186
HIS A 169
 None
 0.81A 2zmaA-3p9zA:
undetectable		 2zmaA-3p9zA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 3p9z UROPORPHYRINOGEN III
COSYNTHASE (HEMD)
(Helicobacter
pylori) 		4 / 6 LEU A 126
GLY A 130
LEU A 122
SER A 121
 None
None
MLI  A 301 (-4.9A)
None
 0.93A 3aiaA-3p9zA:
undetectable		 3aiaA-3p9zA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3p9z UROPORPHYRINOGEN III
COSYNTHASE (HEMD)
(Helicobacter
pylori) 		4 / 8 VAL A 110
LEU A 126
ILE A 101
MET A  88
 None
 0.82A 3u5kA-3p9zA:
undetectable		 3u5kA-3p9zA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3p9z UROPORPHYRINOGEN III
COSYNTHASE (HEMD)
(Helicobacter
pylori) 		4 / 8 VAL A 110
LEU A 126
ILE A 101
MET A  88
 None
 0.78A 3u5kC-3p9zA:
undetectable		 3u5kC-3p9zA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3p9z UROPORPHYRINOGEN III
COSYNTHASE (HEMD)
(Helicobacter
pylori) 		4 / 8 VAL A 110
LEU A 126
ILE A 101
MET A  88
 None
 0.72A 3u5kD-3p9zA:
undetectable		 3u5kD-3p9zA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3p9z UROPORPHYRINOGEN III
COSYNTHASE (HEMD)
(Helicobacter
pylori) 		4 / 7 LEU A 113
ALA A 136
LEU A  28
LEU A  38
 None
 0.68A 4z90F-3p9zA:
undetectable
4z90G-3p9zA:
undetectable
4z90H-3p9zA:
undetectable
4z90J-3p9zA:
undetectable		 4z90F-3p9zA:
18.83
4z90G-3p9zA:
18.83
4z90H-3p9zA:
18.83
4z90J-3p9zA:
18.83