SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pa8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3pa8 TOXIN B
(Clostridioides
difficile) 		5 / 12 GLY A 154
GLY A 111
PHE A 115
GLN A  42
ALA A 196
 621  A 300 ( 3.7A)
621  A 300 (-4.2A)
None
None
None
 1.12A 3dh0B-3pa8A:
3.4		 3dh0B-3pa8A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 3pa8 TOXIN B
(Clostridioides
difficile) 		5 / 12 VAL A  63
ILE A 143
ILE A 180
MET A 184
VAL A 176
 None
 1.15A 3g8iA-3pa8A:
undetectable		 3g8iA-3pa8A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3pa8 TOXIN B
(Clostridioides
difficile) 		5 / 12 LEU A  26
ALA A  50
GLY A 207
SER A 205
LEU A  54
 None
621  A 300 ( 4.1A)
None
None
None
 1.38A 3ou6D-3pa8A:
undetectable		 3ou6D-3pa8A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 3pa8 TOXIN B
(Clostridioides
difficile) 		4 / 6 LEU A 152
ASN A 151
LEU A  41
ILE A  38
 None
IHP  A 257 ( 4.0A)
None
None
 1.13A 4okxA-3pa8A:
undetectable		 4okxA-3pa8A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 3pa8 TOXIN B
(Clostridioides
difficile) 		4 / 7 ILE A  35
LEU A 105
ALA A 139
ILE A  93
 None
 0.66A 4y03A-3pa8A:
undetectable		 4y03A-3pa8A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 3pa8 TOXIN B
(Clostridioides
difficile) 		3 / 3 THR A 167
THR A 117
PHE A 120
 None
 0.79A 5cxvA-3pa8A:
undetectable		 5cxvA-3pa8A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 3pa8 TOXIN B
(Clostridioides
difficile) 		4 / 6 PHE A 107
ASN A 151
LEU A 153
GLY A 109
 None
IHP  A 257 ( 4.0A)
621  A 300 ( 4.8A)
621  A 300 (-4.8A)
 1.15A 5o4yA-3pa8A:
undetectable		 5o4yA-3pa8A:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 3pa8 TOXIN B
(Clostridioides
difficile) 		5 / 12 PRO A  94
ILE A  85
LEU A  20
PHE A  55
SER A  62
 None
 1.23A 6b52A-3pa8A:
undetectable		 6b52A-3pa8A:
22.97