SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3paj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 3paj NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE,
CARBOXYLATING
(Vibrio
cholerae) 		5 / 9 THR A 143
LEU A 147
TYR A 136
ALA A 269
LEU A 262
 None
 1.09A 2npnA-3pajA:
undetectable		 2npnA-3pajA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 3paj NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE,
CARBOXYLATING
(Vibrio
cholerae) 		5 / 11 ALA A 197
ILE A 194
ALA A 226
ALA A 228
VAL A 210
 None
 1.04A 2qhfA-3pajA:
undetectable		 2qhfA-3pajA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 3paj NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE,
CARBOXYLATING
(Vibrio
cholerae) 		4 / 6 MET A 241
ASN A 248
LEU A 254
ASP A 274
 None
 1.41A 3lslG-3pajA:
undetectable		 3lslG-3pajA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 3paj NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE,
CARBOXYLATING
(Vibrio
cholerae) 		5 / 6 PHE A 294
ALA A  57
GLY A 107
PRO A 108
VAL A  84
 None
 1.43A 4dubB-3pajA:
undetectable		 4dubB-3pajA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3paj NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE,
CARBOXYLATING
(Vibrio
cholerae) 		4 / 8 SER A 277
GLU A 211
TYR A 181
LYS A 208
 None
 1.06A 4fgzA-3pajA:
undetectable
4fgzB-3pajA:
undetectable		 4fgzA-3pajA:
20.81
4fgzB-3pajA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3paj NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE,
CARBOXYLATING
(Vibrio
cholerae) 		5 / 12 LEU A 147
ALA A 132
ILE A 260
GLY A 279
ALA A 280
 None
 1.14A 4nkvA-3pajA:
undetectable		 4nkvA-3pajA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 3paj NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE,
CARBOXYLATING
(Vibrio
cholerae) 		4 / 7 ARG A  24
GLU A  75
TRP A  72
PRO A  19
 None
 1.48A 6a4iB-3pajA:
undetectable		 6a4iB-3pajA:
25.62