SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pam'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3pam TRANSMEMBRANE
PROTEIN
(Bartonella
henselae) 		5 / 12 LEU A 424
PHE A 325
MET A 494
PHE A 444
ILE A 471
 None
 1.49A 1xosA-3pamA:
undetectable		 1xosA-3pamA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3pam TRANSMEMBRANE
PROTEIN
(Bartonella
henselae) 		4 / 7 TYR A 566
GLY A 528
THR A 327
ASN A 525
 None
None
None
EOH  A   1 (-3.6A)
 0.99A 2g70A-3pamA:
undetectable		 2g70A-3pamA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3pam TRANSMEMBRANE
PROTEIN
(Bartonella
henselae) 		4 / 7 TYR A 566
GLY A 528
THR A 327
ASN A 525
 None
None
None
EOH  A   1 (-3.6A)
 0.99A 2g70B-3pamA:
undetectable		 2g70B-3pamA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 3pam TRANSMEMBRANE
PROTEIN
(Bartonella
henselae) 		3 / 3 VAL A 458
GLU A 454
GLU A 455
 None
 0.80A 2nv4A-3pamA:
undetectable		 2nv4A-3pamA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3pam TRANSMEMBRANE
PROTEIN
(Bartonella
henselae) 		5 / 12 THR A 362
VAL A 397
LEU A 394
ILE A 562
TYR A 365
 None
 1.41A 3elzC-3pamA:
undetectable		 3elzC-3pamA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 3pam TRANSMEMBRANE
PROTEIN
(Bartonella
henselae) 		5 / 10 PHE A 446
ILE A 448
ILE A 568
SER A 342
LEU A 466
 None
 1.14A 3o1xA-3pamA:
undetectable		 3o1xA-3pamA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 3pam TRANSMEMBRANE
PROTEIN
(Bartonella
henselae) 		5 / 10 PHE A 446
ILE A 448
ILE A 568
SER A 342
LEU A 466
 None
 1.12A 3qgzA-3pamA:
undetectable		 3qgzA-3pamA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 3pam TRANSMEMBRANE
PROTEIN
(Bartonella
henselae) 		4 / 6 PRO A 505
GLY A 506
ASN A 507
LEU A 542
 None
 0.99A 3zqtA-3pamA:
undetectable		 3zqtA-3pamA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 3pam TRANSMEMBRANE
PROTEIN
(Bartonella
henselae) 		3 / 3 ASP A 535
TRP A 366
SER A 517
 None
 1.00A 4lrhA-3pamA:
undetectable		 4lrhA-3pamA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 3pam TRANSMEMBRANE
PROTEIN
(Bartonella
henselae) 		4 / 7 PHE A 462
ILE A 568
ASN A 416
ARG A 361
 None
 1.21A 4o7gA-3pamA:
undetectable
4o7gB-3pamA:
undetectable		 4o7gA-3pamA:
25.80
4o7gB-3pamA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 3pam TRANSMEMBRANE
PROTEIN
(Bartonella
henselae) 		4 / 7 ASN A 501
SER A 369
ILE A 370
LEU A 371
 None
 1.02A 5u4sA-3pamA:
undetectable		 5u4sA-3pamA:
20.00