SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pas'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3pas TETR FAMILY
TRANSCRIPTION
REGULATOR
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 8 SER A  73
ALA A  69
HIS A  89
ILE A  94
 None
 0.81A 1gtnA-3pasA:
undetectable
1gtnB-3pasA:
undetectable		 1gtnA-3pasA:
17.01
1gtnB-3pasA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 3pas TETR FAMILY
TRANSCRIPTION
REGULATOR
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 7 LEU A 101
PHE A 102
THR A 109
ILE A 118
 None
None
ACT  A 211 ( 4.3A)
None
 0.82A 2bdmA-3pasA:
undetectable		 2bdmA-3pasA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3pas TETR FAMILY
TRANSCRIPTION
REGULATOR
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 PHE A 155
MET A 154
ALA A 187
ALA A 189
LEU A  80
 None
 1.26A 2x2nB-3pasA:
undetectable		 2x2nB-3pasA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3pas TETR FAMILY
TRANSCRIPTION
REGULATOR
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 PHE A 155
MET A 154
ALA A 187
ALA A 189
LEU A  80
 None
 1.29A 2x2nC-3pasA:
undetectable		 2x2nC-3pasA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3pas TETR FAMILY
TRANSCRIPTION
REGULATOR
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 PHE A 155
MET A 154
ALA A 187
ALA A 189
LEU A  80
 None
 1.35A 2x2nD-3pasA:
undetectable		 2x2nD-3pasA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3pas TETR FAMILY
TRANSCRIPTION
REGULATOR
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 GLN A  87
LEU A  84
LEU A  80
ALA A  70
ALA A 132
 None
None
None
None
PGO  A 216 ( 4.6A)
 1.11A 3b0wA-3pasA:
2.2		 3b0wA-3pasA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 3pas TETR FAMILY
TRANSCRIPTION
REGULATOR
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 8 LEU A  96
GLY A  95
GLU A 100
ALA A  21
 None
 0.89A 4rjdA-3pasA:
undetectable
4rjdB-3pasA:
undetectable		 4rjdA-3pasA:
14.94
4rjdB-3pasA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 3pas TETR FAMILY
TRANSCRIPTION
REGULATOR
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 PHE A 155
MET A 154
ALA A 187
ALA A 189
LEU A  80
 None
 1.16A 6aycA-3pasA:
undetectable		 6aycA-3pasA:
18.28