SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pb0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		 3pb0 DIHYDRODIPICOLINATE
SYNTHASE
(Thermotoga
maritima) 		4 / 7 HIS A 117
LEU A  85
THR A  81
THR A  84
 None
 0.94A 1am6A-3pb0A:
undetectable		 1am6A-3pb0A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 3pb0 DIHYDRODIPICOLINATE
SYNTHASE
(Thermotoga
maritima) 		5 / 10 ALA A 276
LEU A 261
ARG A 285
ILE A 265
LEU A 269
 None
 1.41A 1qkuA-3pb0A:
undetectable		 1qkuA-3pb0A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 3pb0 DIHYDRODIPICOLINATE
SYNTHASE
(Thermotoga
maritima) 		5 / 10 ALA A 276
LEU A 261
ARG A 285
ILE A 265
LEU A 269
 None
 1.41A 1qkuB-3pb0A:
undetectable		 1qkuB-3pb0A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 3pb0 DIHYDRODIPICOLINATE
SYNTHASE
(Thermotoga
maritima) 		5 / 10 ALA A 276
LEU A 261
ARG A 285
ILE A 265
LEU A 269
 None
 1.40A 1qkuC-3pb0A:
undetectable		 1qkuC-3pb0A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 3pb0 DIHYDRODIPICOLINATE
SYNTHASE
(Thermotoga
maritima) 		5 / 12 MET A 185
GLY A 201
ALA A 200
ASP A 171
TYR A 196
 None
 1.46A 2avdA-3pb0A:
undetectable		 2avdA-3pb0A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)		 3pb0 DIHYDRODIPICOLINATE
SYNTHASE
(Thermotoga
maritima) 		5 / 12 GLY A 189
VAL A 130
ILE A  73
GLY A   6
VAL A   5
 None
 1.13A 2avsB-3pb0A:
undetectable		 2avsB-3pb0A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3pb0 DIHYDRODIPICOLINATE
SYNTHASE
(Thermotoga
maritima) 		4 / 6 VAL A 205
SER A 188
LEU A 220
HIS A 236
 None
 1.26A 2f8dA-3pb0A:
undetectable		 2f8dA-3pb0A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3pb0 DIHYDRODIPICOLINATE
SYNTHASE
(Thermotoga
maritima) 		4 / 7 MET A 217
GLN A 216
LEU A 239
ASP A 191
 None
 1.01A 2qqcB-3pb0A:
undetectable
2qqcC-3pb0A:
undetectable		 2qqcB-3pb0A:
20.07
2qqcC-3pb0A:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3pb0 DIHYDRODIPICOLINATE
SYNTHASE
(Thermotoga
maritima) 		4 / 7 MET A 217
GLN A 216
LEU A 239
LEU A 246
 None
 0.77A 2qqcB-3pb0A:
undetectable
2qqcC-3pb0A:
undetectable		 2qqcB-3pb0A:
20.07
2qqcC-3pb0A:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3pb0 DIHYDRODIPICOLINATE
SYNTHASE
(Thermotoga
maritima) 		5 / 7 LEU A 239
ASP A 191
LEU A 246
MET A 217
GLN A 216
 None
 1.11A 2qqcA-3pb0A:
undetectable
2qqcF-3pb0A:
undetectable		 2qqcA-3pb0A:
11.45
2qqcF-3pb0A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3pb0 DIHYDRODIPICOLINATE
SYNTHASE
(Thermotoga
maritima) 		4 / 7 LEU A 239
ASP A 191
MET A 217
GLN A 216
 None
 0.97A 2qqcG-3pb0A:
undetectable
2qqcJ-3pb0A:
undetectable		 2qqcG-3pb0A:
11.45
2qqcJ-3pb0A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3pb0 DIHYDRODIPICOLINATE
SYNTHASE
(Thermotoga
maritima) 		4 / 7 LEU A 239
LEU A 246
MET A 217
GLN A 216
 None
 0.75A 2qqcG-3pb0A:
undetectable
2qqcJ-3pb0A:
undetectable		 2qqcG-3pb0A:
11.45
2qqcJ-3pb0A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3pb0 DIHYDRODIPICOLINATE
SYNTHASE
(Thermotoga
maritima) 		4 / 7 LEU A 239
ASP A 191
MET A 217
GLN A 216
 None
 1.00A 2qqcI-3pb0A:
undetectable
2qqcL-3pb0A:
undetectable		 2qqcI-3pb0A:
11.45
2qqcL-3pb0A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3pb0 DIHYDRODIPICOLINATE
SYNTHASE
(Thermotoga
maritima) 		4 / 7 LEU A 239
LEU A 246
MET A 217
GLN A 216
 None
 0.77A 2qqcI-3pb0A:
undetectable
2qqcL-3pb0A:
undetectable		 2qqcI-3pb0A:
11.45
2qqcL-3pb0A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3pb0 DIHYDRODIPICOLINATE
SYNTHASE
(Thermotoga
maritima) 		4 / 7 LEU A 239
ASP A 191
LEU A 246
MET A 217
 None
 1.07A 2qqdA-3pb0A:
undetectable
2qqdE-3pb0A:
undetectable		 2qqdA-3pb0A:
11.45
2qqdE-3pb0A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 3pb0 DIHYDRODIPICOLINATE
SYNTHASE
(Thermotoga
maritima) 		5 / 12 THR A 194
ILE A 206
GLY A   4
GLY A 204
ALA A 222
 None
 1.09A 2yvlA-3pb0A:
undetectable		 2yvlA-3pb0A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_E_C2FE995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 3pb0 DIHYDRODIPICOLINATE
SYNTHASE
(Thermotoga
maritima) 		5 / 11 GLN A  30
THR A   7
GLN A 216
LEU A 242
LEU A 259
 None
 1.47A 3fsuE-3pb0A:
11.4		 3fsuE-3pb0A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 3pb0 DIHYDRODIPICOLINATE
SYNTHASE
(Thermotoga
maritima) 		5 / 12 ASN A  15
GLU A 268
GLU A 266
VAL A 281
GLU A 278
 None
 1.15A 3jayA-3pb0A:
undetectable		 3jayA-3pb0A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3pb0 DIHYDRODIPICOLINATE
SYNTHASE
(Thermotoga
maritima) 		4 / 8 GLY A  98
LEU A 127
ILE A  -4
THR A   0
 None
 0.85A 4em2A-3pb0A:
undetectable		 4em2A-3pb0A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 3pb0 DIHYDRODIPICOLINATE
SYNTHASE
(Thermotoga
maritima) 		5 / 12 ILE A 265
TYR A  23
THR A  44
ASN A 251
ILE A   9
 None
 1.47A 4xe0A-3pb0A:
undetectable		 4xe0A-3pb0A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 3pb0 DIHYDRODIPICOLINATE
SYNTHASE
(Thermotoga
maritima) 		5 / 12 PRO A 214
TYR A  23
THR A  44
ASN A 251
ILE A   9
 None
 1.39A 4xe0A-3pb0A:
undetectable		 4xe0A-3pb0A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3pb0 DIHYDRODIPICOLINATE
SYNTHASE
(Thermotoga
maritima) 		3 / 3 LEU A  38
PHE A   2
ILE A  39
 None
 0.68A 5dzk1-3pb0A:
undetectable
5dzkF-3pb0A:
3.4
5dzkM-3pb0A:
2.6		 5dzk1-3pb0A:
0.67
5dzkF-3pb0A:
22.95
5dzkM-3pb0A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3pb0 DIHYDRODIPICOLINATE
SYNTHASE
(Thermotoga
maritima) 		4 / 5 LEU A  38
PHE A   2
ILE A  39
ILE A 206
 None
 1.04A 5dzk4-3pb0A:
undetectable
5dzkg-3pb0A:
3.4
5dzkm-3pb0A:
2.6
5dzkn-3pb0A:
1.5		 5dzk4-3pb0A:
0.67
5dzkg-3pb0A:
22.95
5dzkm-3pb0A:
22.60
5dzkn-3pb0A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 3pb0 DIHYDRODIPICOLINATE
SYNTHASE
(Thermotoga
maritima) 		4 / 6 GLY A 202
SER A 175
THR A 177
VAL A 186
 None
 1.16A 5ysiA-3pb0A:
undetectable		 5ysiA-3pb0A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AY4_A_TPFA506_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 3pb0 DIHYDRODIPICOLINATE
SYNTHASE
(Thermotoga
maritima) 		5 / 10 TYR A 118
ALA A 152
PHE A 184
ALA A 148
THR A 173
 None
 1.26A 6ay4A-3pb0A:
undetectable		 6ay4A-3pb0A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 3pb0 DIHYDRODIPICOLINATE
SYNTHASE
(Thermotoga
maritima) 		4 / 6 GLN A  30
VAL A  72
LEU A 259
PRO A  12
 None
 1.26A 6brdB-3pb0A:
undetectable		 6brdB-3pb0A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 3pb0 DIHYDRODIPICOLINATE
SYNTHASE
(Thermotoga
maritima) 		4 / 8 GLN A 169
THR A 173
VAL A 174
LYS A 178
 None
 0.87A 6fbvC-3pb0A:
undetectable		 6fbvC-3pb0A:
14.84