SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pbi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 3pbi INVASION PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 167
GLY A 172
ALA A 177
GLN A 200
ASP A  37
 None
 1.28A 1i9gA-3pbiA:
undetectable		 1i9gA-3pbiA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3pbi INVASION PROTEIN
(Mycobacterium
tuberculosis) 		4 / 8 PRO A 168
THR A 232
PHE A 193
ASP A 173
 None
 1.22A 1p7lC-3pbiA:
undetectable		 1p7lC-3pbiA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3pbi INVASION PROTEIN
(Mycobacterium
tuberculosis) 		4 / 8 PRO A 168
THR A 232
PHE A 193
ASP A 173
 None
 1.21A 1p7lD-3pbiA:
undetectable		 1p7lD-3pbiA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 3pbi INVASION PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 THR A 203
VAL A 226
VAL A 235
ASP A 190
 None
 1.01A 1p7rA-3pbiA:
undetectable		 1p7rA-3pbiA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3pbi INVASION PROTEIN
(Mycobacterium
tuberculosis) 		4 / 8 PRO A 168
THR A 232
PHE A 193
ASP A 173
 None
 1.20A 1rg9A-3pbiA:
undetectable		 1rg9A-3pbiA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3pbi INVASION PROTEIN
(Mycobacterium
tuberculosis) 		4 / 8 PRO A 168
THR A 232
PHE A 193
ASP A 173
 None
 1.19A 1rg9B-3pbiA:
undetectable		 1rg9B-3pbiA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3pbi INVASION PROTEIN
(Mycobacterium
tuberculosis) 		4 / 8 PRO A 168
THR A 232
PHE A 193
ASP A 173
 None
 1.21A 1rg9C-3pbiA:
undetectable		 1rg9C-3pbiA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3pbi INVASION PROTEIN
(Mycobacterium
tuberculosis) 		4 / 8 PRO A 168
THR A 232
PHE A 193
ASP A 173
 None
 1.20A 1rg9D-3pbiA:
undetectable		 1rg9D-3pbiA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)		 3pbi INVASION PROTEIN
(Mycobacterium
tuberculosis) 		5 / 11 THR A  69
THR A  67
ARG A 118
GLY A  74
ALA A 161
 None
 1.18A 2f162-3pbiA:
undetectable		 2f162-3pbiA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 3pbi INVASION PROTEIN
(Mycobacterium
tuberculosis) 		5 / 11 THR A  69
THR A  67
ARG A 118
GLY A  74
ALA A 161
 None
 1.17A 2f16N-3pbiA:
undetectable		 2f16N-3pbiA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 3pbi INVASION PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 173
THR A 232
PRO A 233
 None
 0.72A 2pynB-3pbiA:
undetectable		 2pynB-3pbiA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3pbi INVASION PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 ASN A  57
ARG A 169
ASP A 142
 None
 0.93A 2qe6A-3pbiA:
undetectable		 2qe6A-3pbiA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3pbi INVASION PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 ASN A  57
ARG A 169
ASP A 142
 None
 0.94A 2qe6B-3pbiA:
undetectable		 2qe6B-3pbiA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WB9_A_CYSA301_0
(GLUTATHIONE
TRANSFERASE SIGMA
CLASS)		 3pbi INVASION PROTEIN
(Mycobacterium
tuberculosis) 		4 / 5 TYR A 241
GLY A 189
ARG A 188
TYR A 205
 None
 1.08A 2wb9A-3pbiA:
undetectable		 2wb9A-3pbiA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3pbi INVASION PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  46
ASP A 151
ALA A 214
ILE A 167
LEU A 191
 None
 1.04A 3dauA-3pbiA:
undetectable		 3dauA-3pbiA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 3pbi INVASION PROTEIN
(Mycobacterium
tuberculosis) 		5 / 11 THR A  69
THR A  67
ARG A 118
GLY A  74
ALA A 161
 None
 1.20A 3mg0N-3pbiA:
undetectable		 3mg0N-3pbiA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 3pbi INVASION PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 127
ASP A 151
SER A 153
HIS A 201
 None
 1.33A 4arcA-3pbiA:
undetectable		 4arcA-3pbiA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3pbi INVASION PROTEIN
(Mycobacterium
tuberculosis) 		5 / 11 THR A  69
THR A  67
ARG A 118
GLY A  74
ALA A 161
 None
 1.26A 4qvlV-3pbiA:
undetectable
4qvlb-3pbiA:
undetectable		 4qvlV-3pbiA:
21.14
4qvlb-3pbiA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3pbi INVASION PROTEIN
(Mycobacterium
tuberculosis) 		5 / 11 THR A  69
THR A  67
ARG A 118
GLY A  74
ALA A 161
 None
 1.25A 4qvlH-3pbiA:
undetectable
4qvlN-3pbiA:
undetectable		 4qvlH-3pbiA:
21.14
4qvlN-3pbiA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3pbi INVASION PROTEIN
(Mycobacterium
tuberculosis) 		5 / 11 THR A  69
THR A  67
ARG A 118
GLY A  74
ALA A 161
 None
 1.25A 4qvwV-3pbiA:
undetectable
4qvwb-3pbiA:
undetectable		 4qvwV-3pbiA:
21.14
4qvwb-3pbiA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3pbi INVASION PROTEIN
(Mycobacterium
tuberculosis) 		5 / 11 THR A  69
THR A  67
ARG A 118
GLY A  74
ALA A 161
 None
 1.25A 4qvwH-3pbiA:
undetectable
4qvwN-3pbiA:
undetectable		 4qvwH-3pbiA:
21.14
4qvwN-3pbiA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3pbi INVASION PROTEIN
(Mycobacterium
tuberculosis) 		5 / 11 THR A  69
THR A  67
ARG A 118
GLY A  74
ALA A 161
 None
 1.27A 4qw0V-3pbiA:
undetectable
4qw0b-3pbiA:
undetectable		 4qw0V-3pbiA:
21.14
4qw0b-3pbiA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3pbi INVASION PROTEIN
(Mycobacterium
tuberculosis) 		5 / 11 THR A  69
THR A  67
ARG A 118
GLY A  74
ALA A 161
 None
 1.26A 4qw0H-3pbiA:
undetectable
4qw0N-3pbiA:
undetectable		 4qw0H-3pbiA:
21.14
4qw0N-3pbiA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3pbi INVASION PROTEIN
(Mycobacterium
tuberculosis) 		5 / 11 THR A  69
THR A  67
ARG A 118
GLY A  74
ALA A 161
 None
 1.24A 4qw3V-3pbiA:
undetectable
4qw3b-3pbiA:
undetectable		 4qw3V-3pbiA:
21.14
4qw3b-3pbiA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3pbi INVASION PROTEIN
(Mycobacterium
tuberculosis) 		5 / 11 THR A  69
THR A  67
ARG A 118
GLY A  74
ALA A 161
 None
 1.24A 4qw3H-3pbiA:
undetectable
4qw3N-3pbiA:
undetectable		 4qw3H-3pbiA:
21.14
4qw3N-3pbiA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 3pbi INVASION PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 THR A 232
GLY A 199
TYR A 175
GLY A 197
 None
 0.76A 4rdxA-3pbiA:
undetectable		 4rdxA-3pbiA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 3pbi INVASION PROTEIN
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 199
ASN A 176
ASP A 173
ALA A  54
PRO A  49
 None
 1.14A 4xj7C-3pbiA:
undetectable
4xj7D-3pbiA:
undetectable		 4xj7C-3pbiA:
24.53
4xj7D-3pbiA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3pbi INVASION PROTEIN
(Mycobacterium
tuberculosis) 		5 / 11 THR A  69
THR A  67
ARG A 118
GLY A  74
ALA A 161
 None
 1.25A 5cz7H-3pbiA:
undetectable
5cz7N-3pbiA:
undetectable		 5cz7H-3pbiA:
21.14
5cz7N-3pbiA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3pbi INVASION PROTEIN
(Mycobacterium
tuberculosis) 		5 / 11 THR A  69
THR A  67
ARG A 118
GLY A  74
ALA A 161
 None
 1.25A 5d0xV-3pbiA:
undetectable
5d0xb-3pbiA:
undetectable		 5d0xV-3pbiA:
21.14
5d0xb-3pbiA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3pbi INVASION PROTEIN
(Mycobacterium
tuberculosis) 		5 / 11 THR A  69
THR A  67
ARG A 118
GLY A  74
ALA A 161
 None
 1.25A 5d0xH-3pbiA:
undetectable
5d0xN-3pbiA:
undetectable		 5d0xH-3pbiA:
21.14
5d0xN-3pbiA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3pbi INVASION PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 THR A  69
THR A  67
ARG A 118
GLY A  74
ALA A 161
 None
 1.25A 5l5zV-3pbiA:
undetectable
5l5zb-3pbiA:
undetectable		 5l5zV-3pbiA:
21.14
5l5zb-3pbiA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3pbi INVASION PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 THR A  69
THR A  67
ARG A 118
GLY A  74
ALA A 161
 None
 1.25A 5l5zH-3pbiA:
undetectable
5l5zN-3pbiA:
undetectable		 5l5zH-3pbiA:
21.14
5l5zN-3pbiA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3pbi INVASION PROTEIN
(Mycobacterium
tuberculosis) 		5 / 11 THR A  69
THR A  67
ARG A 118
GLY A  74
ALA A 161
 None
 1.26A 5l66V-3pbiA:
undetectable
5l66b-3pbiA:
undetectable		 5l66V-3pbiA:
21.14
5l66b-3pbiA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3pbi INVASION PROTEIN
(Mycobacterium
tuberculosis) 		5 / 11 THR A  69
THR A  67
ARG A 118
GLY A  74
ALA A 161
 None
 1.26A 5l66H-3pbiA:
undetectable
5l66N-3pbiA:
undetectable		 5l66H-3pbiA:
21.14
5l66N-3pbiA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 3pbi INVASION PROTEIN
(Mycobacterium
tuberculosis) 		5 / 7 GLY A 230
GLY A 195
PRO A 196
GLY A 197
GLY A 198
 None
 0.98A 6ag0A-3pbiA:
undetectable		 6ag0A-3pbiA:
20.00