SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pdf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 3pdf DIPEPTIDYL PEPTIDASE
1
(Homo
sapiens) 		6 / 10 GLN A 228
GLY A 232
SER A 233
PHE A 237
HIS A 381
ALA A 382
 LXV  A 442 (-3.4A)
LXV  A 442 (-3.5A)
None
None
None
LXV  A 442 ( 3.8A)
 0.31A 1stfE-3pdfA:
29.4
1stfI-3pdfA:
undetectable		 1stfE-3pdfA:
19.00
1stfI-3pdfA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 3pdf DIPEPTIDYL PEPTIDASE
1
(Homo
sapiens) 		5 / 12 TYR A 316
ALA A 287
GLY A 291
ILE A 282
ILE A 436
 None
 1.18A 1ve3A-3pdfA:
undetectable		 1ve3A-3pdfA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 3pdf DIPEPTIDYL PEPTIDASE
1
(Homo
sapiens) 		4 / 7 ALA A   4
TYR A  83
TYR A 235
PHE A  80
 None
 1.16A 2ajvH-3pdfA:
undetectable
2ajvL-3pdfA:
undetectable		 2ajvH-3pdfA:
17.94
2ajvL-3pdfA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 3pdf DIPEPTIDYL PEPTIDASE
1
(Homo
sapiens) 		3 / 3 ARG A 226
GLN A 262
PRO A 261
 None
 0.97A 2qhfA-3pdfA:
undetectable		 2qhfA-3pdfA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 3pdf DIPEPTIDYL PEPTIDASE
1
(Homo
sapiens) 		4 / 5 PHE A 113
SER A 268
PHE A  68
ILE A 282
 None
 1.02A 2v0mD-3pdfA:
undetectable		 2v0mD-3pdfA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 3pdf DIPEPTIDYL PEPTIDASE
1
(Homo
sapiens) 		4 / 7 TYR A 321
VAL A 431
TYR A 323
ILE A  63
 None
None
CL  A 443 (-4.7A)
None
 1.13A 2x45B-3pdfA:
3.8		 2x45B-3pdfA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 3pdf DIPEPTIDYL PEPTIDASE
1
(Homo
sapiens) 		4 / 7 TYR A 321
VAL A 431
TYR A 323
ILE A  63
 None
None
CL  A 443 (-4.7A)
None
 1.12A 2x45C-3pdfA:
undetectable		 2x45C-3pdfA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 3pdf DIPEPTIDYL PEPTIDASE
1
(Homo
sapiens) 		4 / 7 GLN A 228
GLY A 232
HIS A 381
TRP A 405
 LXV  A 442 (-3.4A)
LXV  A 442 (-3.5A)
None
None
 0.51A 3ai8A-3pdfA:
29.6		 3ai8A-3pdfA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 3pdf DIPEPTIDYL PEPTIDASE
1
(Homo
sapiens) 		4 / 7 TYR A 321
VAL A 431
TYR A 323
ILE A  63
 None
None
CL  A 443 (-4.7A)
None
 1.07A 3bu1A-3pdfA:
undetectable		 3bu1A-3pdfA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 3pdf DIPEPTIDYL PEPTIDASE
1
(Homo
sapiens) 		3 / 3 ALA A  79
VAL A 102
TRP A  77
 None
 0.85A 3l8lC-3pdfA:
undetectable
3l8lD-3pdfA:
undetectable		 3l8lC-3pdfA:
2.13
3l8lD-3pdfA:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 3pdf DIPEPTIDYL PEPTIDASE
1
(Homo
sapiens) 		5 / 12 PHE A  80
SER A 268
THR A  97
ILE A 282
ALA A 287
 None
 1.18A 3nxuB-3pdfA:
undetectable		 3nxuB-3pdfA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 3pdf DIPEPTIDYL PEPTIDASE
1
(Homo
sapiens) 		4 / 6 LEU A 243
PRO A 437
GLN A 255
PRO A 257
 None
 1.40A 3vkxA-3pdfA:
undetectable		 3vkxA-3pdfA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD506_1
(HEMOLYTIC LECTIN
CEL-III)		 3pdf DIPEPTIDYL PEPTIDASE
1
(Homo
sapiens) 		4 / 5 ASP A 304
GLU A 275
GLY A 273
GLN A 262
 None
 1.42A 3w9tD-3pdfA:
undetectable		 3w9tD-3pdfA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE505_1
(HEMOLYTIC LECTIN
CEL-III)		 3pdf DIPEPTIDYL PEPTIDASE
1
(Homo
sapiens) 		4 / 5 ASP A 304
GLU A 275
GLY A 273
GLN A 262
 None
 1.39A 3w9tE-3pdfA:
undetectable		 3w9tE-3pdfA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG505_1
(HEMOLYTIC LECTIN
CEL-III)		 3pdf DIPEPTIDYL PEPTIDASE
1
(Homo
sapiens) 		4 / 5 ASP A 304
GLU A 275
GLY A 273
GLN A 262
 None
 1.42A 3w9tG-3pdfA:
undetectable		 3w9tG-3pdfA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 3pdf DIPEPTIDYL PEPTIDASE
1
(Homo
sapiens) 		4 / 5 LEU A 335
GLU A 427
LEU A 207
HIS A 343
 None
 1.32A 4xi3B-3pdfA:
undetectable		 4xi3B-3pdfA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3pdf DIPEPTIDYL PEPTIDASE
1
(Homo
sapiens) 		4 / 6 PHE A 278
PRO A 279
THR A 379
ILE A 429
 LXV  A 442 ( 3.8A)
CL  A 443 ( 4.0A)
LXV  A 442 (-4.2A)
None
 1.27A 5ih0A-3pdfA:
1.7		 5ih0A-3pdfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3pdf DIPEPTIDYL PEPTIDASE
1
(Homo
sapiens) 		4 / 5 ILE A 249
ILE A 219
HIS A 217
VAL A 216
 None
 0.98A 5jmnA-3pdfA:
undetectable		 5jmnA-3pdfA:
17.88