SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pdg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3pdg FIBRONECTIN(III)-LIK
E MODULE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 THR A  82
ILE A  19
SER A   6
ILE A   4
VAL A  84
 None
 0.97A 1z9hD-3pdgA:
undetectable		 1z9hD-3pdgA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 3pdg FIBRONECTIN(III)-LIK
E MODULE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ALA A  23
PHE A  36
ALA A  53
PRO A  50
 None
None
None
NA  A  99 (-4.3A)
 0.88A 4du2B-3pdgA:
undetectable		 4du2B-3pdgA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 3pdg FIBRONECTIN(III)-LIK
E MODULE
(Ruminiclostridiu
m
thermocellum) 		4 / 5 ILE A  43
ASN A  64
TYR A  63
ILE A  55
 None
 1.08A 4jtpA-3pdgA:
undetectable		 4jtpA-3pdgA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 3pdg FIBRONECTIN(III)-LIK
E MODULE
(Ruminiclostridiu
m
thermocellum) 		6 / 12 ASP A  18
GLY A  57
ALA A  58
ILE A  21
PRO A   7
VAL A  84
 None
 1.24A 4xdrA-3pdgA:
undetectable		 4xdrA-3pdgA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 3pdg FIBRONECTIN(III)-LIK
E MODULE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 THR A  52
TYR A  51
PRO A  50
THR A  48
 NA  A  99 ( 4.5A)
None
NA  A  99 (-4.3A)
None
 1.31A 5b6iA-3pdgA:
undetectable		 5b6iA-3pdgA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3pdg FIBRONECTIN(III)-LIK
E MODULE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 SER A   6
SER A  22
PHE A  13
 None
 0.97A 5mugA-3pdgA:
undetectable		 5mugA-3pdgA:
21.35