SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pdt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YVL_B_SAMB602_1 (HYPOTHETICAL PROTEIN)	3pdt	MYOSIN HEAVY CHAIN KINASE A (Dictyostelium discoideum)	3 / 3	GLU A 713 ASP A 663 TYR A 647	None	0.61A	2yvlB-3pdtA: undetectable	2yvlB-3pdtA: 23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V5W_A_8PRA701_2 (G-PROTEIN COUPLED RECEPTOR KINASE 2)	3pdt	MYOSIN HEAVY CHAIN KINASE A (Dictyostelium discoideum)	3 / 3	LEU A 689 MET A 668 ASP A 663	None	0.89A	3v5wA-3pdtA: 4.7	3v5wA-3pdtA: 15.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4ZME_A_ADNA1002_1 (MYOSIN HEAVY CHAIN KINASE A)	3pdt	MYOSIN HEAVY CHAIN KINASE A (Dictyostelium discoideum)	10 / 11	ALA A 587 GLY A 589 VAL A 643 LYS A 645 LEU A 689 GLU A 713 LEU A 715 LEU A 716 PHE A 720 THR A 765	ADP A 811 (-3.3A) ADP A 811 (-2.9A) None ADP A 811 (-2.7A) None None ADP A 811 ( 4.8A) ADP A 811 (-3.8A) ADP A 811 (-3.5A) ADP A 811 (-4.1A)	0.67A	4zmeA-3pdtA: 40.2	4zmeA-3pdtA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4ZME_A_ADNA1002_1 (MYOSIN HEAVY CHAIN KINASE A)	3pdt	MYOSIN HEAVY CHAIN KINASE A (Dictyostelium discoideum)	10 / 11	PHE A 586 ALA A 587 GLY A 589 VAL A 643 LYS A 645 LEU A 689 LEU A 715 LEU A 716 PHE A 720 THR A 765	ADP A 811 (-4.8A) ADP A 811 (-3.3A) ADP A 811 (-2.9A) None ADP A 811 (-2.7A) None ADP A 811 ( 4.8A) ADP A 811 (-3.8A) ADP A 811 (-3.5A) ADP A 811 (-4.1A)	0.32A	4zmeA-3pdtA: 40.2	4zmeA-3pdtA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4ZME_B_ADNB902_1 (MYOSIN HEAVY CHAIN KINASE A)	3pdt	MYOSIN HEAVY CHAIN KINASE A (Dictyostelium discoideum)	9 / 10	ALA A 587 VAL A 643 LYS A 645 LEU A 689 GLU A 713 LEU A 715 LEU A 716 PHE A 720 THR A 765	ADP A 811 (-3.3A) None ADP A 811 (-2.7A) None None ADP A 811 ( 4.8A) ADP A 811 (-3.8A) ADP A 811 (-3.5A) ADP A 811 (-4.1A)	0.67A	4zmeB-3pdtA: 40.1	4zmeB-3pdtA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4ZME_B_ADNB902_1 (MYOSIN HEAVY CHAIN KINASE A)	3pdt	MYOSIN HEAVY CHAIN KINASE A (Dictyostelium discoideum)	9 / 10	PHE A 586 ALA A 587 VAL A 643 LYS A 645 LEU A 689 LEU A 715 LEU A 716 PHE A 720 THR A 765	ADP A 811 (-4.8A) ADP A 811 (-3.3A) None ADP A 811 (-2.7A) None ADP A 811 ( 4.8A) ADP A 811 (-3.8A) ADP A 811 (-3.5A) ADP A 811 (-4.1A)	0.25A	4zmeB-3pdtA: 40.1	4zmeB-3pdtA: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AN0_A_HISA520_0 (HISTIDINOL DEHYDROGENASE)	3pdt	MYOSIN HEAVY CHAIN KINASE A (Dictyostelium discoideum)	4 / 6	ARG A 592 GLU A 593 ALA A 594 LYS A 645	ADP A 811 (-4.1A) None ADP A 811 ( 3.8A) ADP A 811 (-2.7A)	0.48A	6an0A-3pdtA: undetectable	6an0A-3pdtA: 21.41

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2YVL_B_SAMB602_1","HYPOTHETICAL PROTEIN","3pdt","MYOSIN HEAVY CHAIN KINASE A","Dictyostelium discoideum",3,"GLU A 713;ASP A 663;TYR A 647","None","0.61A","2yvlB-3pdtA:undetectable","2yvlB-3pdtA:23.81"],["3V5W_A_8PRA701_2","G-PROTEIN COUPLED RECEPTOR KINASE 2","3pdt","MYOSIN HEAVY CHAIN KINASE A","Dictyostelium discoideum",3,"LEU A 689;MET A 668;ASP A 663","None","0.89A","3v5wA-3pdtA:4.7","3v5wA-3pdtA:15.37"],["4ZME_A_ADNA1002_1","MYOSIN HEAVY CHAIN KINASE A","3pdt","MYOSIN HEAVY CHAIN KINASE A","Dictyostelium discoideum",10,"ALA A 587;GLY A 589;VAL A 643;LYS A 645;LEU A 689;GLU A 713;LEU A 715;LEU A 716;PHE A 720;THR A 765","ADP A 811 (-3.3A);ADP A 811 (-2.9A);None;ADP A 811 (-2.7A);None;None;ADP A 811 ( 4.8A);ADP A 811 (-3.8A);ADP A 811 (-3.5A);ADP A 811 (-4.1A)","0.67A","4zmeA-3pdtA:40.2","4zmeA-3pdtA:100.00"],["4ZME_A_ADNA1002_1","MYOSIN HEAVY CHAIN KINASE A","3pdt","MYOSIN HEAVY CHAIN KINASE A","Dictyostelium discoideum",10,"PHE A 586;ALA A 587;GLY A 589;VAL A 643;LYS A 645;LEU A 689;LEU A 715;LEU A 716;PHE A 720;THR A 765","ADP A 811 (-4.8A);ADP A 811 (-3.3A);ADP A 811 (-2.9A);None;ADP A 811 (-2.7A);None;ADP A 811 ( 4.8A);ADP A 811 (-3.8A);ADP A 811 (-3.5A);ADP A 811 (-4.1A)","0.32A","4zmeA-3pdtA:40.2","4zmeA-3pdtA:100.00"],["4ZME_B_ADNB902_1","MYOSIN HEAVY CHAIN KINASE A","3pdt","MYOSIN HEAVY CHAIN KINASE A","Dictyostelium discoideum",9,"ALA A 587;VAL A 643;LYS A 645;LEU A 689;GLU A 713;LEU A 715;LEU A 716;PHE A 720;THR A 765","ADP A 811 (-3.3A);None;ADP A 811 (-2.7A);None;None;ADP A 811 ( 4.8A);ADP A 811 (-3.8A);ADP A 811 (-3.5A);ADP A 811 (-4.1A)","0.67A","4zmeB-3pdtA:40.1","4zmeB-3pdtA:100.00"],["4ZME_B_ADNB902_1","MYOSIN HEAVY CHAIN KINASE A","3pdt","MYOSIN HEAVY CHAIN KINASE A","Dictyostelium discoideum",9,"PHE A 586;ALA A 587;VAL A 643;LYS A 645;LEU A 689;LEU A 715;LEU A 716;PHE A 720;THR A 765","ADP A 811 (-4.8A);ADP A 811 (-3.3A);None;ADP A 811 (-2.7A);None;ADP A 811 ( 4.8A);ADP A 811 (-3.8A);ADP A 811 (-3.5A);ADP A 811 (-4.1A)","0.25A","4zmeB-3pdtA:40.1","4zmeB-3pdtA:100.00"],["6AN0_A_HISA520_0","HISTIDINOL DEHYDROGENASE","3pdt","MYOSIN HEAVY CHAIN KINASE A","Dictyostelium discoideum",4,"ARG A 592;GLU A 593;ALA A 594;LYS A 645","ADP A 811 (-4.1A);None;ADP A 811 ( 3.8A);ADP A 811 (-2.7A)","0.48A","6an0A-3pdtA:undetectable","6an0A-3pdtA:21.41"]]