SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pdu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3pdu 3-HYDROXYISOBUTYRATE
DEHYDROGENASE FAMILY
PROTEIN
(Geobacter
sulfurreducens) 		4 / 5 SER A 102
THR A 103
GLU A 118
GLY A 139
 None
 0.74A 1icrA-3pduA:
undetectable
1icrB-3pduA:
undetectable		 1icrA-3pduA:
21.20
1icrB-3pduA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3pdu 3-HYDROXYISOBUTYRATE
DEHYDROGENASE FAMILY
PROTEIN
(Geobacter
sulfurreducens) 		4 / 5 GLU A 118
GLY A 139
SER A 102
THR A 103
 None
 0.73A 1icrA-3pduA:
undetectable
1icrB-3pduA:
undetectable		 1icrA-3pduA:
21.20
1icrB-3pduA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3pdu 3-HYDROXYISOBUTYRATE
DEHYDROGENASE FAMILY
PROTEIN
(Geobacter
sulfurreducens) 		4 / 6 SER A 102
THR A 103
GLU A 118
GLY A 139
 None
 0.77A 1icuA-3pduA:
undetectable
1icuB-3pduA:
undetectable		 1icuA-3pduA:
21.20
1icuB-3pduA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3pdu 3-HYDROXYISOBUTYRATE
DEHYDROGENASE FAMILY
PROTEIN
(Geobacter
sulfurreducens) 		4 / 6 GLU A 118
GLY A 139
SER A 102
THR A 103
 None
 0.76A 1icuA-3pduA:
undetectable
1icuB-3pduA:
undetectable		 1icuA-3pduA:
21.20
1icuB-3pduA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3pdu 3-HYDROXYISOBUTYRATE
DEHYDROGENASE FAMILY
PROTEIN
(Geobacter
sulfurreducens) 		4 / 6 SER A 102
THR A 103
GLU A 118
GLY A 139
 None
 0.78A 1icuC-3pduA:
undetectable
1icuD-3pduA:
undetectable		 1icuC-3pduA:
21.20
1icuD-3pduA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3pdu 3-HYDROXYISOBUTYRATE
DEHYDROGENASE FAMILY
PROTEIN
(Geobacter
sulfurreducens) 		4 / 5 SER A 102
THR A 103
GLU A 118
GLY A 139
 None
 0.77A 1icvC-3pduA:
undetectable
1icvD-3pduA:
undetectable		 1icvC-3pduA:
21.20
1icvD-3pduA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3pdu 3-HYDROXYISOBUTYRATE
DEHYDROGENASE FAMILY
PROTEIN
(Geobacter
sulfurreducens) 		4 / 5 GLU A 118
GLY A 139
SER A 102
THR A 103
 None
 0.76A 1icvC-3pduA:
undetectable
1icvD-3pduA:
undetectable		 1icvC-3pduA:
21.20
1icvD-3pduA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3pdu 3-HYDROXYISOBUTYRATE
DEHYDROGENASE FAMILY
PROTEIN
(Geobacter
sulfurreducens) 		4 / 6 SER A 102
THR A 103
GLU A 118
GLY A 139
 None
 0.77A 1kqbA-3pduA:
undetectable
1kqbB-3pduA:
undetectable		 1kqbA-3pduA:
23.59
1kqbB-3pduA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3pdu 3-HYDROXYISOBUTYRATE
DEHYDROGENASE FAMILY
PROTEIN
(Geobacter
sulfurreducens) 		4 / 5 GLU A 118
GLY A 139
SER A 102
THR A 103
 None
 0.78A 1kqbA-3pduA:
undetectable
1kqbB-3pduA:
undetectable		 1kqbA-3pduA:
23.59
1kqbB-3pduA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3pdu 3-HYDROXYISOBUTYRATE
DEHYDROGENASE FAMILY
PROTEIN
(Geobacter
sulfurreducens) 		4 / 6 SER A 102
THR A 103
GLU A 118
GLY A 139
 None
 0.73A 1kqbC-3pduA:
undetectable
1kqbD-3pduA:
undetectable		 1kqbC-3pduA:
23.59
1kqbD-3pduA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3pdu 3-HYDROXYISOBUTYRATE
DEHYDROGENASE FAMILY
PROTEIN
(Geobacter
sulfurreducens) 		4 / 6 GLU A 118
GLY A 139
SER A 102
THR A 103
 None
 0.74A 1kqbC-3pduA:
undetectable
1kqbD-3pduA:
undetectable		 1kqbC-3pduA:
23.59
1kqbD-3pduA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 3pdu 3-HYDROXYISOBUTYRATE
DEHYDROGENASE FAMILY
PROTEIN
(Geobacter
sulfurreducens) 		3 / 3 SER A  95
ASP A  98
ASP A  67
 None
 0.60A 2plwA-3pduA:
6.5		 2plwA-3pduA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 3pdu 3-HYDROXYISOBUTYRATE
DEHYDROGENASE FAMILY
PROTEIN
(Geobacter
sulfurreducens) 		4 / 6 THR A  96
VAL A  97
LEU A 172
SER A 102
 NAP  A 301 (-4.1A)
None
None
None
 1.00A 3b6rB-3pduA:
undetectable		 3b6rB-3pduA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 3pdu 3-HYDROXYISOBUTYRATE
DEHYDROGENASE FAMILY
PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 GLY A   8
GLY A  10
GLY A  14
ARG A  32
LEU A  65
 NAP  A 301 (-3.5A)
NAP  A 301 (-3.6A)
None
NAP  A 301 (-3.3A)
NAP  A 301 (-4.3A)
 0.96A 3ihtA-3pduA:
5.0		 3ihtA-3pduA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 3pdu 3-HYDROXYISOBUTYRATE
DEHYDROGENASE FAMILY
PROTEIN
(Geobacter
sulfurreducens) 		4 / 5 LEU A 154
PHE A 151
PRO A 149
ALA A 147
 None
 1.46A 3vm4A-3pduA:
undetectable		 3vm4A-3pduA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3pdu 3-HYDROXYISOBUTYRATE
DEHYDROGENASE FAMILY
PROTEIN
(Geobacter
sulfurreducens) 		4 / 6 ARG A  72
GLU A 246
ASP A  98
ASP A  99
 None
GOL  A 304 (-4.6A)
None
None
 1.30A 4kcnA-3pduA:
undetectable		 4kcnA-3pduA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 3pdu 3-HYDROXYISOBUTYRATE
DEHYDROGENASE FAMILY
PROTEIN
(Geobacter
sulfurreducens) 		4 / 8 ALA A 279
VAL A 281
SER A 264
GLY A 186
 None
 1.02A 5v0vA-3pduA:
undetectable		 5v0vA-3pduA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 3pdu 3-HYDROXYISOBUTYRATE
DEHYDROGENASE FAMILY
PROTEIN
(Geobacter
sulfurreducens) 		4 / 7 ILE A 177
LEU A 241
PHE A 265
THR A  96
 None
None
None
NAP  A 301 (-4.1A)
 1.01A 5vc0A-3pduA:
undetectable		 5vc0A-3pduA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 3pdu 3-HYDROXYISOBUTYRATE
DEHYDROGENASE FAMILY
PROTEIN
(Geobacter
sulfurreducens) 		5 / 11 PHE A 151
GLY A 155
ILE A 135
ILE A  92
ILE A  62
 None
 1.08A 6gp2B-3pduA:
undetectable		 6gp2B-3pduA:
14.45