SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pdw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3pdw UNCHARACTERIZED
HYDROLASE YUTF
(Bacillus
subtilis) 		4 / 7 GLY A 217
THR A 245
THR A 224
ILE A 218
 None
 0.92A 1gtnF-3pdwA:
undetectable
1gtnG-3pdwA:
undetectable		 1gtnF-3pdwA:
16.79
1gtnG-3pdwA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3pdw UNCHARACTERIZED
HYDROLASE YUTF
(Bacillus
subtilis) 		4 / 7 GLY A 217
THR A 245
THR A 224
ILE A 218
 None
 0.92A 1gtnJ-3pdwA:
undetectable
1gtnK-3pdwA:
undetectable		 1gtnJ-3pdwA:
16.79
1gtnK-3pdwA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 3pdw UNCHARACTERIZED
HYDROLASE YUTF
(Bacillus
subtilis) 		4 / 7 GLU A  69
GLU A  68
GLU A 105
MET A  76
 None
 1.11A 1linA-3pdwA:
undetectable		 1linA-3pdwA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 3pdw UNCHARACTERIZED
HYDROLASE YUTF
(Bacillus
subtilis) 		4 / 4 LEU A 204
THR A 203
ILE A 258
HIS A 262
 None
None
None
ACY  A 269 (-4.0A)
 1.18A 2jfaB-3pdwA:
undetectable		 2jfaB-3pdwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 3pdw UNCHARACTERIZED
HYDROLASE YUTF
(Bacillus
subtilis) 		3 / 3 ARG A 124
VAL A 119
THR A 147
 None
 0.80A 2nmzA-3pdwA:
undetectable		 2nmzA-3pdwA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 3pdw UNCHARACTERIZED
HYDROLASE YUTF
(Bacillus
subtilis) 		3 / 3 ARG A 124
VAL A 119
THR A 147
 None
 0.77A 2nnkA-3pdwA:
undetectable		 2nnkA-3pdwA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3pdw UNCHARACTERIZED
HYDROLASE YUTF
(Bacillus
subtilis) 		5 / 12 LEU A 204
VAL A 206
ILE A 258
LEU A  34
PHE A  30
 None
 0.98A 3datA-3pdwA:
undetectable		 3datA-3pdwA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3pdw UNCHARACTERIZED
HYDROLASE YUTF
(Bacillus
subtilis) 		5 / 12 LEU A 204
VAL A 206
ILE A 258
LEU A  34
PHE A  30
 None
 0.98A 3fl9B-3pdwA:
undetectable		 3fl9B-3pdwA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3pdw UNCHARACTERIZED
HYDROLASE YUTF
(Bacillus
subtilis) 		5 / 11 LEU A 204
VAL A 206
ILE A 258
LEU A  34
PHE A  30
 None
 0.96A 3fl9C-3pdwA:
undetectable		 3fl9C-3pdwA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3pdw UNCHARACTERIZED
HYDROLASE YUTF
(Bacillus
subtilis) 		5 / 12 LEU A 204
VAL A 206
ILE A 258
LEU A  34
PHE A  30
 None
 1.01A 3fl9G-3pdwA:
undetectable		 3fl9G-3pdwA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3pdw UNCHARACTERIZED
HYDROLASE YUTF
(Bacillus
subtilis) 		5 / 9 LEU A 204
VAL A 206
ILE A 258
LEU A  34
PHE A  30
 None
 0.93A 3fl9H-3pdwA:
undetectable		 3fl9H-3pdwA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 3pdw UNCHARACTERIZED
HYDROLASE YUTF
(Bacillus
subtilis) 		5 / 10 LEU A 204
VAL A 206
ILE A 258
LEU A  34
PHE A  30
 None
 0.97A 3jw5B-3pdwA:
undetectable		 3jw5B-3pdwA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 3pdw UNCHARACTERIZED
HYDROLASE YUTF
(Bacillus
subtilis) 		3 / 3 ARG A 124
VAL A 119
THR A 147
 None
 0.79A 3k4vA-3pdwA:
undetectable		 3k4vA-3pdwA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 3pdw UNCHARACTERIZED
HYDROLASE YUTF
(Bacillus
subtilis) 		3 / 3 ARG A 124
VAL A 119
THR A 147
 None
 0.83A 3k4vD-3pdwA:
undetectable		 3k4vD-3pdwA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 3pdw UNCHARACTERIZED
HYDROLASE YUTF
(Bacillus
subtilis) 		3 / 3 ARG A 124
VAL A 119
THR A 147
 None
 0.86A 3nduD-3pdwA:
undetectable		 3nduD-3pdwA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 3pdw UNCHARACTERIZED
HYDROLASE YUTF
(Bacillus
subtilis) 		3 / 3 ARG A 124
VAL A 119
THR A 147
 None
 0.78A 3pwrA-3pdwA:
undetectable		 3pwrA-3pdwA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 3pdw UNCHARACTERIZED
HYDROLASE YUTF
(Bacillus
subtilis) 		3 / 3 ARG A 124
VAL A 119
THR A 147
 None
 0.82A 3tl9A-3pdwA:
undetectable		 3tl9A-3pdwA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 3pdw UNCHARACTERIZED
HYDROLASE YUTF
(Bacillus
subtilis) 		3 / 3 ASP A 239
LYS A 237
ASP A 240
 None
 0.70A 4a7tA-3pdwA:
undetectable		 4a7tA-3pdwA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3pdw UNCHARACTERIZED
HYDROLASE YUTF
(Bacillus
subtilis) 		5 / 12 GLU A  96
ASP A 150
SER A  49
ASN A  47
ILE A 122
 None
GOL  A 267 (-3.5A)
None
GOL  A 267 (-4.1A)
None
 1.42A 4djfA-3pdwA:
undetectable		 4djfA-3pdwA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3pdw UNCHARACTERIZED
HYDROLASE YUTF
(Bacillus
subtilis) 		5 / 12 GLY A 164
GLY A 149
ILE A 151
VAL A 172
GLN A 177
 None
 1.23A 4fglA-3pdwA:
2.7
4fglB-3pdwA:
undetectable		 4fglA-3pdwA:
23.27
4fglB-3pdwA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 3pdw UNCHARACTERIZED
HYDROLASE YUTF
(Bacillus
subtilis) 		5 / 12 LEU A  13
GLY A  15
VAL A 206
MET A 205
ILE A  24
 None
GOL  A 268 (-3.2A)
None
None
None
 1.41A 4oktA-3pdwA:
undetectable		 4oktA-3pdwA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_B_PARB500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 3pdw UNCHARACTERIZED
HYDROLASE YUTF
(Bacillus
subtilis) 		5 / 9 PHE A 180
SER A 168
SER A 146
GLU A  96
ASP A 123
 None
 1.50A 4qb9B-3pdwA:
0.0		 4qb9B-3pdwA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3pdw UNCHARACTERIZED
HYDROLASE YUTF
(Bacillus
subtilis) 		5 / 8 THR A 198
LEU A  42
VAL A  31
LEU A  34
ILE A  11
 None
 1.09A 4r38A-3pdwA:
undetectable		 4r38A-3pdwA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3pdw UNCHARACTERIZED
HYDROLASE YUTF
(Bacillus
subtilis) 		5 / 9 THR A 198
LEU A  42
VAL A  31
LEU A  34
ILE A  11
 None
 1.08A 4r38C-3pdwA:
undetectable		 4r38C-3pdwA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3pdw UNCHARACTERIZED
HYDROLASE YUTF
(Bacillus
subtilis) 		5 / 11 VAL A 172
GLN A 177
GLY A 164
GLY A 149
ILE A 151
 None
 1.15A 4zvmA-3pdwA:
undetectable
4zvmB-3pdwA:
undetectable		 4zvmA-3pdwA:
23.27
4zvmB-3pdwA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 3pdw UNCHARACTERIZED
HYDROLASE YUTF
(Bacillus
subtilis) 		5 / 9 LEU A 251
VAL A 206
HIS A 246
TRP A 254
ILE A  11
 None
None
None
ACY  A 269 ( 4.5A)
None
 1.20A 5om2A-3pdwA:
undetectable
5om2B-3pdwA:
undetectable		 5om2A-3pdwA:
14.39
5om2B-3pdwA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 3pdw UNCHARACTERIZED
HYDROLASE YUTF
(Bacillus
subtilis) 		3 / 3 ARG A  32
LYS A  35
TYR A  41
 None
 1.20A 6gnaA-3pdwA:
undetectable		 6gnaA-3pdwA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 3pdw UNCHARACTERIZED
HYDROLASE YUTF
(Bacillus
subtilis) 		3 / 3 ARG A  32
LYS A  35
TYR A  41
 None
 1.20A 6gnbA-3pdwA:
undetectable		 6gnbA-3pdwA:
19.33