SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pdx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 3pdx TYROSINE
AMINOTRANSFERASE
(Mus
musculus) 		3 / 3 LEU A 198
HIS A 229
LYS A 232
 None
 0.90A 1y7iA-3pdxA:
2.6		 1y7iA-3pdxA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3pdx TYROSINE
AMINOTRANSFERASE
(Mus
musculus) 		5 / 11 LEU A 363
ILE A 378
HIS A 441
PHE A 383
PHE A 437
 None
 1.18A 1zz1A-3pdxA:
3.3		 1zz1A-3pdxA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_1
(POL POLYPROTEIN)		 3pdx TYROSINE
AMINOTRANSFERASE
(Mus
musculus) 		5 / 12 LEU A 331
GLY A 325
ALA A 326
VAL A  93
ILE A 330
 None
 0.91A 2avvD-3pdxA:
undetectable		 2avvD-3pdxA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 3pdx TYROSINE
AMINOTRANSFERASE
(Mus
musculus) 		4 / 4 LEU A  87
PRO A  88
LEU A 283
ARG A 281
 None
None
LLP  A 280 ( 4.5A)
None
 1.30A 2hrcA-3pdxA:
undetectable		 2hrcA-3pdxA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3pdx TYROSINE
AMINOTRANSFERASE
(Mus
musculus) 		5 / 12 LEU A 357
VAL A 425
PHE A 345
ASN A  86
ASN A 349
 None
 1.46A 2y00A-3pdxA:
undetectable		 2y00A-3pdxA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3pdx TYROSINE
AMINOTRANSFERASE
(Mus
musculus) 		4 / 8 LEU A 278
THR A 334
ALA A 326
ALA A  96
 None
 0.84A 3ax9B-3pdxA:
undetectable		 3ax9B-3pdxA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3pdx TYROSINE
AMINOTRANSFERASE
(Mus
musculus) 		3 / 3 GLY A 143
GLY A 277
GLY A 290
 LLP  A 280 ( 3.1A)
None
None
 0.39A 3bogC-3pdxA:
undetectable		 3bogC-3pdxA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3pdx TYROSINE
AMINOTRANSFERASE
(Mus
musculus) 		3 / 3 GLY A 143
GLY A 277
GLY A 290
 LLP  A 280 ( 3.1A)
None
None
 0.42A 3bogD-3pdxA:
undetectable		 3bogD-3pdxA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3pdx TYROSINE
AMINOTRANSFERASE
(Mus
musculus) 		4 / 8 THR A 334
LEU A 331
ALA A 326
ALA A  96
 None
 0.95A 3ns1L-3pdxA:
undetectable		 3ns1L-3pdxA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_2
(PROTEASE)		 3pdx TYROSINE
AMINOTRANSFERASE
(Mus
musculus) 		5 / 11 LEU A 331
GLY A 325
ALA A 326
VAL A  93
ILE A 330
 None
 0.89A 3nu3B-3pdxA:
undetectable		 3nu3B-3pdxA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_1
(PROTEASE)		 3pdx TYROSINE
AMINOTRANSFERASE
(Mus
musculus) 		5 / 12 LEU A 331
GLY A 325
ALA A 326
VAL A  93
ILE A 330
 None
 0.87A 3nu5A-3pdxA:
undetectable		 3nu5A-3pdxA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_2
(PROTEASE)		 3pdx TYROSINE
AMINOTRANSFERASE
(Mus
musculus) 		5 / 12 LEU A 331
GLY A 325
ALA A 326
VAL A  93
ILE A 330
 None
 0.87A 3nu5B-3pdxA:
undetectable		 3nu5B-3pdxA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_2
(PROTEASE)		 3pdx TYROSINE
AMINOTRANSFERASE
(Mus
musculus) 		5 / 9 LEU A 331
GLY A 325
ALA A 326
VAL A  93
ILE A 330
 None
 0.91A 3nujB-3pdxA:
undetectable		 3nujB-3pdxA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)		 3pdx TYROSINE
AMINOTRANSFERASE
(Mus
musculus) 		5 / 9 LEU A 331
GLY A 325
ALA A 326
VAL A  93
ILE A 330
 None
 0.97A 3oxvC-3pdxA:
undetectable		 3oxvC-3pdxA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_1
(PROTEASE)		 3pdx TYROSINE
AMINOTRANSFERASE
(Mus
musculus) 		5 / 12 LEU A 331
GLY A 325
ALA A 326
VAL A  93
ILE A 330
 None
 0.94A 3pwmA-3pdxA:
undetectable		 3pwmA-3pdxA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_3
(PROTEASE)		 3pdx TYROSINE
AMINOTRANSFERASE
(Mus
musculus) 		5 / 12 LEU A 331
GLY A 325
ALA A 326
VAL A  93
ILE A 330
 None
 0.91A 3pwrB-3pdxA:
undetectable		 3pwrB-3pdxA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 3pdx TYROSINE
AMINOTRANSFERASE
(Mus
musculus) 		4 / 5 ILE A 113
PRO A 111
SER A 117
GLY A 114
 None
 1.01A 3tkdB-3pdxA:
undetectable		 3tkdB-3pdxA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 3pdx TYROSINE
AMINOTRANSFERASE
(Mus
musculus) 		4 / 5 ILE A 113
PRO A 111
SER A 117
GLY A 114
 None
 1.01A 3tkdA-3pdxA:
undetectable		 3tkdA-3pdxA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3pdx TYROSINE
AMINOTRANSFERASE
(Mus
musculus) 		4 / 7 TYR A 260
ASN A 215
PRO A 165
TYR A 172
 None
LLP  A 280 ( 3.5A)
None
None
 1.30A 3ugrA-3pdxA:
undetectable		 3ugrA-3pdxA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3pdx TYROSINE
AMINOTRANSFERASE
(Mus
musculus) 		5 / 12 ASN A 349
ALA A 356
GLY A 355
ASP A 351
ILE A 360
 None
 0.99A 4obwB-3pdxA:
3.1		 4obwB-3pdxA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_2
(HIV-1 PROTEASE)		 3pdx TYROSINE
AMINOTRANSFERASE
(Mus
musculus) 		5 / 9 LEU A 331
GLY A 325
ALA A 326
VAL A  93
ILE A 330
 None
 0.93A 4rvjB-3pdxA:
undetectable		 4rvjB-3pdxA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_2
(HIV-1 PROTEASE)		 3pdx TYROSINE
AMINOTRANSFERASE
(Mus
musculus) 		5 / 9 LEU A 331
GLY A 325
ALA A 326
VAL A  93
ILE A 330
 None
 0.92A 4rvjD-3pdxA:
undetectable		 4rvjD-3pdxA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3pdx TYROSINE
AMINOTRANSFERASE
(Mus
musculus) 		4 / 7 ILE A 305
GLY A 302
CYH A 151
ASP A 137
 None
 0.87A 5hieB-3pdxA:
undetectable		 5hieB-3pdxA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3pdx TYROSINE
AMINOTRANSFERASE
(Mus
musculus) 		4 / 8 ILE A 305
GLY A 302
CYH A 151
ASP A 137
 None
 0.88A 5hieD-3pdxA:
undetectable		 5hieD-3pdxA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 3pdx TYROSINE
AMINOTRANSFERASE
(Mus
musculus) 		4 / 7 PHE A 255
LEU A 346
ALA A 350
GLN A 340
 None
 1.06A 6b89A-3pdxA:
undetectable		 6b89A-3pdxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_1
(PROTEASE)		 3pdx TYROSINE
AMINOTRANSFERASE
(Mus
musculus) 		5 / 12 LEU A 331
GLY A 325
ALA A 326
VAL A  93
ILE A 330
 None
 0.85A 6dh3B-3pdxA:
undetectable		 6dh3B-3pdxA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_1
(PROTEASE)		 3pdx TYROSINE
AMINOTRANSFERASE
(Mus
musculus) 		5 / 12 LEU A 331
GLY A 325
ALA A 326
VAL A  93
ILE A 330
 None
 0.82A 6dh6B-3pdxA:
undetectable		 6dh6B-3pdxA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_1
(HIV-1 PROTEASE)		 3pdx TYROSINE
AMINOTRANSFERASE
(Mus
musculus) 		5 / 12 LEU A 331
GLY A 325
ALA A 326
VAL A  93
ILE A 330
 None
 0.85A 6difB-3pdxA:
undetectable		 6difB-3pdxA:
13.03