SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pei'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		4 / 6 ALA A 389
LEU A 382
LEU A 447
LEU A 247
 EDO  A 510 (-4.0A)
EDO  A 502 (-4.1A)
None
None
 0.87A 1mt1D-3peiA:
undetectable
1mt1E-3peiA:
undetectable		 1mt1D-3peiA:
13.54
1mt1E-3peiA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		4 / 8 ASP A 418
ASN A 419
ARG A 422
ALA A 333
 None
None
None
CL  A 496 ( 4.3A)
 1.18A 1rqpC-3peiA:
undetectable		 1rqpC-3peiA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		4 / 8 ALA A 288
ILE A 287
CYH A 164
GLY A 165
 None
None
CL  A 505 ( 4.4A)
None
 0.84A 1sv9A-3peiA:
undetectable		 1sv9A-3peiA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		5 / 12 LEU A 139
LEU A  88
ILE A   3
LEU A  64
VAL A  51
 EDO  A 507 (-4.1A)
None
None
None
None
 1.20A 2po5A-3peiA:
3.1		 2po5A-3peiA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		5 / 12 LEU A 139
LEU A  88
ILE A   3
LEU A  64
VAL A  51
 EDO  A 507 (-4.1A)
None
None
None
None
 1.26A 2po7B-3peiA:
3.4		 2po7B-3peiA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		4 / 6 LEU A 290
ALA A 286
LEU A 292
THR A 283
 EDO  A 491 (-4.2A)
None
None
None
 1.09A 2roxB-3peiA:
undetectable		 2roxB-3peiA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		4 / 6 ASP A 101
ILE A 100
LEU A 144
GLU A  14
 PEG  A 492 (-4.4A)
None
None
None
 1.00A 2ya7A-3peiA:
undetectable		 2ya7A-3peiA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		4 / 6 ASP A 101
ILE A 100
LEU A 144
GLU A  14
 PEG  A 492 (-4.4A)
None
None
None
 0.99A 2ya7B-3peiA:
undetectable		 2ya7B-3peiA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		4 / 6 ASP A 101
ILE A 100
LEU A 144
GLU A  14
 PEG  A 492 (-4.4A)
None
None
None
 0.96A 2ya7D-3peiA:
undetectable		 2ya7D-3peiA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		5 / 12 ILE A 365
LEU A 360
ALA A 333
ASP A 332
ALA A 431
 None
CL  A 496 (-4.4A)
CL  A 496 ( 4.3A)
None
None
 0.93A 2yqzA-3peiA:
undetectable		 2yqzA-3peiA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		4 / 7 LEU A 290
ALA A 286
LEU A 292
THR A 283
 EDO  A 491 (-4.2A)
None
None
None
 0.93A 3cfqA-3peiA:
undetectable
3cfqB-3peiA:
undetectable		 3cfqA-3peiA:
13.33
3cfqB-3peiA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		5 / 12 ILE A 397
ALA A 389
LEU A 386
LEU A 247
ILE A 245
 None
EDO  A 510 (-4.0A)
None
None
None
 1.00A 3gwsX-3peiA:
undetectable		 3gwsX-3peiA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		3 / 3 SER A 452
ASP A 395
ASP A 448
 None
FMT  A 501 (-3.8A)
None
 0.80A 3iv6A-3peiA:
undetectable		 3iv6A-3peiA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		5 / 12 TYR A 372
GLY A 374
GLY A 451
SER A 452
ASP A 456
 None
 1.17A 3ou7A-3peiA:
undetectable		 3ou7A-3peiA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		5 / 12 TYR A 372
GLY A 374
GLY A 451
SER A 452
ASP A 456
 None
 1.16A 3ou7D-3peiA:
undetectable		 3ou7D-3peiA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_A_T44A128_1
(TRANSTHYRETIN)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		5 / 9 LEU A 290
ALA A 286
LEU A 292
THR A 283
VAL A 467
 EDO  A 491 (-4.2A)
None
None
None
None
 1.47A 3ozkA-3peiA:
undetectable		 3ozkA-3peiA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		4 / 7 VAL A 296
LEU A 474
TYR A 473
LEU A 357
 None
 1.04A 3qeoB-3peiA:
undetectable		 3qeoB-3peiA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		5 / 12 ASN A 256
GLY A 335
GLY A 257
ASP A 341
CYH A 340
 None
CL  A 496 ( 3.9A)
None
None
None
 1.37A 3r24A-3peiA:
undetectable		 3r24A-3peiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_2
(HIV-1 PROTEASE)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		6 / 12 LEU A 470
ASP A  78
GLY A 159
ILE A 158
THR A 283
VAL A 467
 None
FMT  A 501 ( 4.8A)
None
None
None
None
 1.43A 3so9B-3peiA:
undetectable		 3so9B-3peiA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		3 / 3 LYS A  59
VAL A  61
HIS A  56
 None
 1.18A 3tj7A-3peiA:
undetectable		 3tj7A-3peiA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		3 / 3 TYR A 345
ASP A 202
ASP A 205
 None
 0.86A 4a6eA-3peiA:
undetectable		 4a6eA-3peiA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		4 / 7 LEU A 290
ALA A 286
LEU A 292
THR A 283
 EDO  A 491 (-4.2A)
None
None
None
 0.93A 4d7bA-3peiA:
undetectable		 4d7bA-3peiA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		5 / 11 ILE A 142
ALA A  85
ALA A  84
ILE A  17
VAL A  98
 None
 1.20A 4h1nA-3peiA:
undetectable		 4h1nA-3peiA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		4 / 6 LEU A 290
ALA A 286
LEU A 292
THR A 283
 EDO  A 491 (-4.2A)
None
None
None
 1.02A 4i89A-3peiA:
undetectable		 4i89A-3peiA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		4 / 6 LEU A 290
ALA A 286
LEU A 292
THR A 283
 EDO  A 491 (-4.2A)
None
None
None
 0.99A 4ikiB-3peiA:
undetectable		 4ikiB-3peiA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		4 / 7 LEU A 290
ALA A 286
LEU A 292
THR A 283
 EDO  A 491 (-4.2A)
None
None
None
 1.00A 4ikjA-3peiA:
undetectable
4ikjB-3peiA:
undetectable		 4ikjA-3peiA:
13.07
4ikjB-3peiA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		4 / 7 LEU A 290
ALA A 286
LEU A 292
THR A 283
 EDO  A 491 (-4.2A)
None
None
None
 0.97A 4ikkA-3peiA:
undetectable
4ikkB-3peiA:
undetectable		 4ikkA-3peiA:
13.07
4ikkB-3peiA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		3 / 3 HIS A 472
GLY A 159
ILE A 162
 None
 0.53A 4k50A-3peiA:
undetectable		 4k50A-3peiA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		3 / 3 HIS A 472
GLY A 159
ILE A 162
 None
 0.52A 4k50I-3peiA:
undetectable		 4k50I-3peiA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		5 / 12 ILE A 100
PHE A 112
ILE A  80
LEU A  66
ILE A  17
 None
 1.08A 4kjkA-3peiA:
undetectable		 4kjkA-3peiA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJQ_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		5 / 11 SER A 452
LEU A 337
ASP A 273
GLY A 275
MET A 274
 None
None
EDO  A 503 (-3.9A)
None
None
 1.40A 4zjqA-3peiA:
undetectable		 4zjqA-3peiA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		4 / 6 LEU A 290
ALA A 286
LEU A 292
THR A 283
 EDO  A 491 (-4.2A)
None
None
None
 1.00A 5l4iA-3peiA:
undetectable		 5l4iA-3peiA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		5 / 12 GLY A 213
VAL A 248
LEU A 204
THR A 230
GLY A 301
 PEG  A 508 (-3.5A)
None
None
None
None
 1.01A 5tuiB-3peiA:
undetectable		 5tuiB-3peiA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		4 / 4 GLY A 335
LEU A 252
VAL A 220
GLU A 334
 CL  A 496 ( 3.9A)
None
None
None
 1.35A 5yw0A-3peiA:
undetectable		 5yw0A-3peiA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		5 / 12 ILE A  81
ALA A  85
GLN A  87
ILE A  96
LEU A  64
 None
None
EDO  A 512 (-3.2A)
None
None
 1.15A 6a5zD-3peiA:
undetectable		 6a5zD-3peiA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		5 / 12 LEU A 172
GLY A 249
GLY A 251
ILE A 449
VAL A 280
 None
 0.95A 6ecxA-3peiA:
undetectable		 6ecxA-3peiA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		4 / 6 MET A 300
GLY A 276
ALA A 169
LEU A 172
 None
 1.02A 6fosA-3peiA:
undetectable		 6fosA-3peiA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		4 / 5 VAL A 296
PHE A 376
MET A 375
GLY A 374
 None
 1.10A 6hd4A-3peiA:
undetectable		 6hd4A-3peiA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3pei CYTOSOL
AMINOPEPTIDASE
(Francisella
tularensis) 		4 / 5 VAL A 297
PHE A 376
MET A 375
GLY A 374
 SO4  A 513 ( 4.9A)
None
None
None
 1.31A 6hd4A-3peiA:
undetectable		 6hd4A-3peiA:
10.32