SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pen'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 3pen TRANSLATION
INITIATION FACTOR 2
SUBUNIT GAMMA
(Sulfolobus
solfataricus) 		6 / 12 THR A 365
ILE A 138
ALA A 108
GLY A 107
ALA A 109
ILE A 139
 None
 1.42A 1bx4A-3penA:
undetectable		 1bx4A-3penA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3pen TRANSLATION
INITIATION FACTOR 2
SUBUNIT GAMMA
(Sulfolobus
solfataricus) 		4 / 6 VAL A 118
VAL A 178
ILE A 115
ARG A 130
 None
 1.05A 1iepA-3penA:
undetectable		 1iepA-3penA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_B_CHDB500_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3pen TRANSLATION
INITIATION FACTOR 2
SUBUNIT GAMMA
(Sulfolobus
solfataricus) 		4 / 4 LEU A 412
VAL A 413
ILE A 331
TRP A 410
 None
 1.31A 1s9qB-3penA:
undetectable		 1s9qB-3penA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 3pen TRANSLATION
INITIATION FACTOR 2
SUBUNIT GAMMA
(Sulfolobus
solfataricus) 		5 / 10 ILE A 191
ALA A  28
VAL A 117
ILE A 115
VAL A  14
 None
 1.01A 2nnjA-3penA:
undetectable		 2nnjA-3penA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 3pen TRANSLATION
INITIATION FACTOR 2
SUBUNIT GAMMA
(Sulfolobus
solfataricus) 		5 / 12 ILE A 315
LEU A 256
GLY A 258
ALA A 387
VAL A 388
 None
 0.95A 2oc8A-3penA:
undetectable		 2oc8A-3penA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3pen TRANSLATION
INITIATION FACTOR 2
SUBUNIT GAMMA
(Sulfolobus
solfataricus) 		4 / 8 LEU A 194
LEU A 144
VAL A  15
GLY A  16
 None
 0.93A 2po5B-3penA:
4.8		 2po5B-3penA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 3pen TRANSLATION
INITIATION FACTOR 2
SUBUNIT GAMMA
(Sulfolobus
solfataricus) 		5 / 12 ILE A 139
GLY A 362
ALA A 108
ALA A 387
VAL A 386
 None
 1.01A 2yvlB-3penA:
2.6		 2yvlB-3penA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 3pen TRANSLATION
INITIATION FACTOR 2
SUBUNIT GAMMA
(Sulfolobus
solfataricus) 		5 / 12 ASN A  55
ILE A  12
ALA A 114
VAL A 147
LEU A 194
 None
 1.21A 3a51E-3penA:
undetectable		 3a51E-3penA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3pen TRANSLATION
INITIATION FACTOR 2
SUBUNIT GAMMA
(Sulfolobus
solfataricus) 		5 / 12 ILE A 272
THR A 274
ILE A 316
ILE A 238
SER A 220
 None
 1.26A 3kpbC-3penA:
undetectable		 3kpbC-3penA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3pen TRANSLATION
INITIATION FACTOR 2
SUBUNIT GAMMA
(Sulfolobus
solfataricus) 		5 / 10 ILE A 272
THR A 274
ILE A 316
ILE A 238
SER A 220
 None
 1.22A 3kpbD-3penA:
undetectable		 3kpbD-3penA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3pen TRANSLATION
INITIATION FACTOR 2
SUBUNIT GAMMA
(Sulfolobus
solfataricus) 		5 / 11 ILE A 272
THR A 274
ILE A 316
ILE A 238
SER A 220
 None
 1.20A 3kpcA-3penA:
undetectable		 3kpcA-3penA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3pen TRANSLATION
INITIATION FACTOR 2
SUBUNIT GAMMA
(Sulfolobus
solfataricus) 		4 / 7 VAL A 118
VAL A 178
ILE A 115
ARG A 130
 None
 1.05A 3mssB-3penA:
undetectable		 3mssB-3penA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3pen TRANSLATION
INITIATION FACTOR 2
SUBUNIT GAMMA
(Sulfolobus
solfataricus) 		3 / 3 VAL A 396
SER A 398
LEU A 105
 None
 0.70A 3n8xA-3penA:
undetectable		 3n8xA-3penA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3pen TRANSLATION
INITIATION FACTOR 2
SUBUNIT GAMMA
(Sulfolobus
solfataricus) 		5 / 11 PRO A 350
ARG A 352
ILE A 351
VAL A 373
VAL A 370
 None
 1.38A 3rf4A-3penA:
undetectable
3rf4C-3penA:
undetectable		 3rf4A-3penA:
16.24
3rf4C-3penA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3pen TRANSLATION
INITIATION FACTOR 2
SUBUNIT GAMMA
(Sulfolobus
solfataricus) 		5 / 11 PRO A 350
ARG A 352
ILE A 351
VAL A 373
VAL A 370
 None
 1.33A 3rf4A-3penA:
undetectable
3rf4B-3penA:
undetectable		 3rf4A-3penA:
16.24
3rf4B-3penA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3pen TRANSLATION
INITIATION FACTOR 2
SUBUNIT GAMMA
(Sulfolobus
solfataricus) 		5 / 11 PRO A 350
ARG A 352
ILE A 351
VAL A 373
VAL A 370
 None
 1.35A 3rf4B-3penA:
undetectable
3rf4C-3penA:
undetectable		 3rf4B-3penA:
16.24
3rf4C-3penA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3pen TRANSLATION
INITIATION FACTOR 2
SUBUNIT GAMMA
(Sulfolobus
solfataricus) 		5 / 12 MET A 215
LEU A 246
ALA A 289
GLU A 288
GLY A 298
 None
None
None
None
5GP  A   1 (-3.7A)
 1.12A 5gtrA-3penA:
undetectable		 5gtrA-3penA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 3pen TRANSLATION
INITIATION FACTOR 2
SUBUNIT GAMMA
(Sulfolobus
solfataricus) 		3 / 3 GLY A 293
ASN A  11
ARG A 207
 None
 0.57A 5w7bD-3penA:
3.5		 5w7bD-3penA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 3pen TRANSLATION
INITIATION FACTOR 2
SUBUNIT GAMMA
(Sulfolobus
solfataricus) 		5 / 12 ALA A  94
PRO A  95
GLY A  96
ASP A 112
GLY A 113
 None
 1.26A 5wwsB-3penA:
undetectable		 5wwsB-3penA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3pen TRANSLATION
INITIATION FACTOR 2
SUBUNIT GAMMA
(Sulfolobus
solfataricus) 		5 / 12 LEU A  25
PHE A  91
THR A  70
ILE A 195
THR A  34
 None
None
MG  A 417 (-4.3A)
None
None
 1.27A 5z6fA-3penA:
undetectable		 5z6fA-3penA:
18.48