SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pet'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 3pet PUTATIVE ADHESIN
(Bacteroides
fragilis) 		5 / 12 LEU A 189
ASN A 207
ALA A 191
ALA A 174
LEU A 176
 None
 0.94A 1fk6A-3petA:
undetectable		 1fk6A-3petA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 3pet PUTATIVE ADHESIN
(Bacteroides
fragilis) 		5 / 11 LEU A 176
LEU A 150
ALA A 171
LEU A 135
VAL A 194
 None
 1.20A 1ictA-3petA:
undetectable
1ictC-3petA:
undetectable		 1ictA-3petA:
22.62
1ictC-3petA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 3pet PUTATIVE ADHESIN
(Bacteroides
fragilis) 		5 / 12 GLY A  50
ALA A  49
ASP A  48
ILE A 116
ILE A  55
 PG4  A 251 ( 4.2A)
None
None
None
None
 0.87A 1sdtB-3petA:
undetectable		 1sdtB-3petA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 3pet PUTATIVE ADHESIN
(Bacteroides
fragilis) 		5 / 11 GLY A  50
ALA A  49
ASP A  48
ILE A 116
ILE A  55
 PG4  A 251 ( 4.2A)
None
None
None
None
 0.87A 1sdvB-3petA:
undetectable		 1sdvB-3petA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)		 3pet PUTATIVE ADHESIN
(Bacteroides
fragilis) 		5 / 12 GLY A  50
ALA A  49
ASP A  48
ILE A 116
ILE A  55
 PG4  A 251 ( 4.2A)
None
None
None
None
 0.87A 2avsB-3petA:
undetectable		 2avsB-3petA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_3
(POL POLYPROTEIN)		 3pet PUTATIVE ADHESIN
(Bacteroides
fragilis) 		5 / 12 GLY A  50
ALA A  49
ASP A  48
ILE A 116
ILE A  55
 PG4  A 251 ( 4.2A)
None
None
None
None
 0.87A 2avvE-3petA:
undetectable		 2avvE-3petA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_2
(POL PROTEIN)		 3pet PUTATIVE ADHESIN
(Bacteroides
fragilis) 		5 / 11 GLY A  50
ALA A  49
ASP A  48
ILE A 116
ILE A  55
 PG4  A 251 ( 4.2A)
None
None
None
None
 0.89A 2fxeB-3petA:
undetectable		 2fxeB-3petA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_2
(PROTEASE)		 3pet PUTATIVE ADHESIN
(Bacteroides
fragilis) 		5 / 12 GLY A  50
ALA A  49
ASP A  48
ILE A 116
ILE A  55
 PG4  A 251 ( 4.2A)
None
None
None
None
 0.83A 2o4kB-3petA:
undetectable		 2o4kB-3petA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 3pet PUTATIVE ADHESIN
(Bacteroides
fragilis) 		5 / 11 LEU A 113
LEU A 135
LEU A 155
ILE A  47
VAL A 145
 None
 1.21A 2qd3A-3petA:
undetectable		 2qd3A-3petA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_2
(PROTEASE)		 3pet PUTATIVE ADHESIN
(Bacteroides
fragilis) 		5 / 12 GLY A  50
ALA A  49
ASP A  48
ILE A 116
ILE A  55
 PG4  A 251 ( 4.2A)
None
None
None
None
 0.86A 2r5pB-3petA:
undetectable		 2r5pB-3petA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_2
(PROTEASE)		 3pet PUTATIVE ADHESIN
(Bacteroides
fragilis) 		5 / 12 GLY A  50
ALA A  49
ASP A  48
ILE A 116
ILE A  55
 PG4  A 251 ( 4.2A)
None
None
None
None
 0.86A 2r5pD-3petA:
undetectable		 2r5pD-3petA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 3pet PUTATIVE ADHESIN
(Bacteroides
fragilis) 		4 / 7 PHE A 118
PHE A 101
ILE A  75
GLY A  50
 None
ACT  A 247 (-4.4A)
ACT  A 247 (-4.9A)
PG4  A 251 ( 4.2A)
 0.82A 2v0mB-3petA:
undetectable		 2v0mB-3petA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 3pet PUTATIVE ADHESIN
(Bacteroides
fragilis) 		4 / 8 GLY A  50
ALA A  49
ASP A  48
ILE A  55
 PG4  A 251 ( 4.2A)
None
None
None
 0.64A 3el0A-3petA:
undetectable		 3el0A-3petA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)		 3pet PUTATIVE ADHESIN
(Bacteroides
fragilis) 		5 / 11 GLY A  50
ALA A  49
ASP A  48
ILE A 116
ILE A  55
 PG4  A 251 ( 4.2A)
None
None
None
None
 0.88A 3em4A-3petA:
undetectable		 3em4A-3petA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 3pet PUTATIVE ADHESIN
(Bacteroides
fragilis) 		5 / 11 GLY A  50
ALA A  49
ASP A  48
ILE A 116
ILE A  55
 PG4  A 251 ( 4.2A)
None
None
None
None
 0.94A 3em4U-3petA:
undetectable		 3em4U-3petA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 3pet PUTATIVE ADHESIN
(Bacteroides
fragilis) 		4 / 7 ILE A 116
SER A 159
LEU A 167
VAL A 165
 None
 0.80A 3ua5B-3petA:
undetectable		 3ua5B-3petA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3pet PUTATIVE ADHESIN
(Bacteroides
fragilis) 		5 / 12 LEU A 113
LEU A 135
LEU A 155
ILE A  47
VAL A 145
 None
 1.21A 4f4dA-3petA:
undetectable		 4f4dA-3petA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 3pet PUTATIVE ADHESIN
(Bacteroides
fragilis) 		5 / 12 ASP A 123
GLN A 148
ILE A 137
ASN A 144
VAL A 165
 None
 1.06A 4fr0A-3petA:
undetectable		 4fr0A-3petA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 3pet PUTATIVE ADHESIN
(Bacteroides
fragilis) 		5 / 11 LEU A 189
LEU A 176
LEU A 130
LEU A 150
LEU A 113
 None
 0.94A 4zowA-3petA:
undetectable		 4zowA-3petA:
22.67