SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pf0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 3pf0 IMELYSIN-LIKE
PROTEIN
(Psychrobacter
arcticus) 		4 / 7 LEU A 275
ALA A 281
LEU A 277
SER A 278
 None
 1.07A 1dvxA-3pf0A:
undetectable		 1dvxA-3pf0A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3pf0 IMELYSIN-LIKE
PROTEIN
(Psychrobacter
arcticus) 		5 / 12 ILE A 172
GLY A 167
GLY A 195
LEU A 152
TYR A 213
 None
 0.95A 1kiaC-3pf0A:
undetectable		 1kiaC-3pf0A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3pf0 IMELYSIN-LIKE
PROTEIN
(Psychrobacter
arcticus) 		5 / 12 ILE A 172
GLY A 167
GLY A 195
LEU A 152
TYR A 213
 None
 0.95A 1nbhB-3pf0A:
undetectable		 1nbhB-3pf0A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3pf0 IMELYSIN-LIKE
PROTEIN
(Psychrobacter
arcticus) 		4 / 8 TYR A  79
THR A 314
LEU A 329
MET A 308
 None
 1.36A 1uw6A-3pf0A:
undetectable
1uw6B-3pf0A:
undetectable		 1uw6A-3pf0A:
19.62
1uw6B-3pf0A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3pf0 IMELYSIN-LIKE
PROTEIN
(Psychrobacter
arcticus) 		4 / 8 TYR A  79
THR A 314
LEU A 329
MET A 308
 None
 1.37A 1uw6D-3pf0A:
undetectable
1uw6E-3pf0A:
undetectable		 1uw6D-3pf0A:
19.62
1uw6E-3pf0A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3pf0 IMELYSIN-LIKE
PROTEIN
(Psychrobacter
arcticus) 		4 / 8 TYR A  79
THR A 314
LEU A 329
MET A 308
 None
 1.38A 1uw6G-3pf0A:
undetectable
1uw6H-3pf0A:
undetectable		 1uw6G-3pf0A:
19.62
1uw6H-3pf0A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3pf0 IMELYSIN-LIKE
PROTEIN
(Psychrobacter
arcticus) 		4 / 8 TYR A  79
THR A 314
LEU A 329
MET A 308
 None
 1.37A 1uw6P-3pf0A:
undetectable
1uw6Q-3pf0A:
undetectable		 1uw6P-3pf0A:
19.62
1uw6Q-3pf0A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3pf0 IMELYSIN-LIKE
PROTEIN
(Psychrobacter
arcticus) 		4 / 8 LEU A 329
MET A 308
TYR A  79
THR A 314
 None
 1.37A 1uw6P-3pf0A:
undetectable
1uw6T-3pf0A:
undetectable		 1uw6P-3pf0A:
19.62
1uw6T-3pf0A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 3pf0 IMELYSIN-LIKE
PROTEIN
(Psychrobacter
arcticus) 		4 / 8 ALA A 212
GLY A 195
SER A 216
ALA A 217
 None
 0.74A 2vh3B-3pf0A:
1.3		 2vh3B-3pf0A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3pf0 IMELYSIN-LIKE
PROTEIN
(Psychrobacter
arcticus) 		4 / 8 HIS A 165
ASP A 204
TYR A 201
LEU A 120
 None
 1.18A 3abmA-3pf0A:
3.0
3abmC-3pf0A:
5.1
3abmP-3pf0A:
5.1		 3abmA-3pf0A:
19.96
3abmC-3pf0A:
20.17
3abmP-3pf0A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 3pf0 IMELYSIN-LIKE
PROTEIN
(Psychrobacter
arcticus) 		5 / 9 VAL A 164
GLY A 167
ILE A 172
TYR A 213
GLY A 195
 None
 1.21A 3csjB-3pf0A:
undetectable		 3csjB-3pf0A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAI_A_AZMA263_1
(CARBONIC ANHYDRASE 9)		 3pf0 IMELYSIN-LIKE
PROTEIN
(Psychrobacter
arcticus) 		5 / 11 GLN A 191
GLU A 181
VAL A 168
LEU A 178
THR A 179
 None
 1.21A 3iaiA-3pf0A:
undetectable		 3iaiA-3pf0A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAI_B_AZMB263_1
(CARBONIC ANHYDRASE 9)		 3pf0 IMELYSIN-LIKE
PROTEIN
(Psychrobacter
arcticus) 		5 / 11 GLN A 191
GLU A 181
VAL A 168
LEU A 178
THR A 179
 None
 1.20A 3iaiB-3pf0A:
undetectable		 3iaiB-3pf0A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAI_C_AZMC263_1
(CARBONIC ANHYDRASE 9)		 3pf0 IMELYSIN-LIKE
PROTEIN
(Psychrobacter
arcticus) 		5 / 11 GLN A 191
GLU A 181
VAL A 168
LEU A 178
THR A 179
 None
 1.20A 3iaiC-3pf0A:
undetectable		 3iaiC-3pf0A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAI_D_AZMD263_1
(CARBONIC ANHYDRASE 9)		 3pf0 IMELYSIN-LIKE
PROTEIN
(Psychrobacter
arcticus) 		5 / 11 GLN A 191
GLU A 181
VAL A 168
LEU A 178
THR A 179
 None
 1.21A 3iaiD-3pf0A:
undetectable		 3iaiD-3pf0A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 3pf0 IMELYSIN-LIKE
PROTEIN
(Psychrobacter
arcticus) 		4 / 7 LEU A 347
LEU A 358
SER A 268
THR A 366
 None
 1.00A 3lm8B-3pf0A:
undetectable
3lm8D-3pf0A:
undetectable		 3lm8B-3pf0A:
21.10
3lm8D-3pf0A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 3pf0 IMELYSIN-LIKE
PROTEIN
(Psychrobacter
arcticus) 		5 / 9 ALA A 220
GLY A 222
LEU A 196
LEU A 225
ILE A 193
 None
 1.20A 3wdmC-3pf0A:
undetectable		 3wdmC-3pf0A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3pf0 IMELYSIN-LIKE
PROTEIN
(Psychrobacter
arcticus) 		4 / 8 HIS A 165
ASP A 204
TYR A 201
LEU A 120
 None
 1.17A 3x2qA-3pf0A:
2.8
3x2qC-3pf0A:
5.2
3x2qP-3pf0A:
5.1		 3x2qA-3pf0A:
19.96
3x2qC-3pf0A:
20.17
3x2qP-3pf0A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 3pf0 IMELYSIN-LIKE
PROTEIN
(Psychrobacter
arcticus) 		4 / 7 GLN A 356
THR A 354
LEU A 339
THR A 331
 None
 1.11A 4mbsA-3pf0A:
1.5		 4mbsA-3pf0A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3pf0 IMELYSIN-LIKE
PROTEIN
(Psychrobacter
arcticus) 		5 / 11 GLU A 181
ALA A 184
LEU A 183
LEU A 178
LEU A 171
 None
 0.98A 4wg0C-3pf0A:
undetectable
4wg0D-3pf0A:
undetectable
4wg0E-3pf0A:
undetectable		 4wg0C-3pf0A:
5.91
4wg0D-3pf0A:
5.91
4wg0E-3pf0A:
5.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3pf0 IMELYSIN-LIKE
PROTEIN
(Psychrobacter
arcticus) 		5 / 11 GLU A 181
ALA A 184
LEU A 183
LEU A 178
LEU A 171
 None
 1.00A 4wg0E-3pf0A:
undetectable
4wg0F-3pf0A:
undetectable
4wg0G-3pf0A:
undetectable		 4wg0E-3pf0A:
5.91
4wg0F-3pf0A:
5.91
4wg0G-3pf0A:
5.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3pf0 IMELYSIN-LIKE
PROTEIN
(Psychrobacter
arcticus) 		5 / 7 LEU A 373
THR A 328
LEU A 329
THR A 324
THR A 376
 None
 1.49A 4z90A-3pf0A:
2.0
4z90B-3pf0A:
1.7
4z90C-3pf0A:
undetectable
4z90D-3pf0A:
undetectable
4z90E-3pf0A:
undetectable		 4z90A-3pf0A:
20.21
4z90B-3pf0A:
20.21
4z90C-3pf0A:
20.21
4z90D-3pf0A:
20.21
4z90E-3pf0A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 3pf0 IMELYSIN-LIKE
PROTEIN
(Psychrobacter
arcticus) 		4 / 6 LEU A 275
ALA A 281
LEU A 277
SER A 278
 None
 1.10A 5a6iA-3pf0A:
undetectable		 5a6iA-3pf0A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3pf0 IMELYSIN-LIKE
PROTEIN
(Psychrobacter
arcticus) 		5 / 10 MET A 215
LEU A 130
SER A  99
ILE A 193
GLY A 192
 None
 1.46A 6dlzA-3pf0A:
undetectable
6dlzD-3pf0A:
3.0		 6dlzA-3pf0A:
14.02
6dlzD-3pf0A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3pf0 IMELYSIN-LIKE
PROTEIN
(Psychrobacter
arcticus) 		5 / 10 ILE A 193
GLY A 192
MET A 215
LEU A 130
SER A  99
 None
 1.46A 6dlzB-3pf0A:
2.9
6dlzC-3pf0A:
undetectable		 6dlzB-3pf0A:
14.02
6dlzC-3pf0A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3pf0 IMELYSIN-LIKE
PROTEIN
(Psychrobacter
arcticus) 		5 / 10 MET A 215
LEU A 130
SER A  99
ILE A 193
GLY A 192
 None
 1.46A 6dm1A-3pf0A:
undetectable
6dm1D-3pf0A:
3.0		 6dm1A-3pf0A:
14.02
6dm1D-3pf0A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3pf0 IMELYSIN-LIKE
PROTEIN
(Psychrobacter
arcticus) 		5 / 10 ILE A 193
GLY A 192
MET A 215
LEU A 130
SER A  99
 None
 1.46A 6dm1B-3pf0A:
3.0
6dm1C-3pf0A:
undetectable		 6dm1B-3pf0A:
14.02
6dm1C-3pf0A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 3pf0 IMELYSIN-LIKE
PROTEIN
(Psychrobacter
arcticus) 		5 / 12 GLY A 195
GLY A 192
VAL A 168
LEU A 171
ILE A 172
 None
 1.00A 6ectA-3pf0A:
undetectable		 6ectA-3pf0A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 3pf0 IMELYSIN-LIKE
PROTEIN
(Psychrobacter
arcticus) 		5 / 12 GLY A 195
GLY A 192
VAL A 168
LEU A 171
ILE A 172
 None
 0.93A 6ecxA-3pf0A:
undetectable		 6ecxA-3pf0A:
23.00