SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pfe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		5 / 10 LEU A 121
ALA A 128
ASP A 130
ASP A 129
GLY A 192
 None
None
ZN  A 501 ( 4.6A)
ZN  A 502 ( 2.3A)
ZN  A 504 ( 3.9A)
 1.14A 1d4yA-3pfeA:
undetectable		 1d4yA-3pfeA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		5 / 12 PRO A 415
GLY A 192
SER A 166
ASP A 129
MET A 452
 GOL  A 520 ( 4.8A)
ZN  A 504 ( 3.9A)
None
ZN  A 502 ( 2.3A)
None
 1.08A 1ffyA-3pfeA:
undetectable		 1ffyA-3pfeA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		3 / 3 PHE A   2
TYR A 400
PRO A   4
 None
 0.73A 1mcnA-3pfeA:
undetectable
1mcnB-3pfeA:
undetectable
1mcnP-3pfeA:
undetectable		 1mcnA-3pfeA:
20.04
1mcnB-3pfeA:
20.04
1mcnP-3pfeA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		6 / 12 GLY A 126
GLY A 127
VAL A 434
LEU A  23
LEU A 448
HIS A  96
 None
None
None
None
None
ZN  A 501 (-3.3A)
 1.14A 1mx1D-3pfeA:
undetectable		 1mx1D-3pfeA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		6 / 12 GLY A 126
GLY A 127
VAL A 434
LEU A  23
LEU A 448
HIS A  96
 None
None
None
None
None
ZN  A 501 (-3.3A)
 1.11A 1mx1F-3pfeA:
undetectable		 1mx1F-3pfeA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		4 / 7 LEU A 311
LEU A 358
ILE A 372
MET A 339
 None
 1.01A 1n13I-3pfeA:
undetectable
1n13L-3pfeA:
undetectable		 1n13I-3pfeA:
7.26
1n13L-3pfeA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		4 / 7 GLY A 211
ILE A 372
ALA A 357
ILE A 245
 None
 0.79A 1n49A-3pfeA:
undetectable		 1n49A-3pfeA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_E_RTLE1_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		5 / 11 LEU A  78
VAL A  70
MET A 419
LEU A 175
TYR A  94
 None
None
GOL  A 520 ( 3.8A)
None
None
 1.49A 1qabE-3pfeA:
undetectable		 1qabE-3pfeA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		5 / 12 PRO A 415
GLY A 192
SER A 166
ASP A 129
MET A 452
 GOL  A 520 ( 4.8A)
ZN  A 504 ( 3.9A)
None
ZN  A 502 ( 2.3A)
None
 1.08A 1qu2A-3pfeA:
undetectable		 1qu2A-3pfeA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		5 / 12 ILE A  29
ASP A  98
ALA A 160
GLY A 131
LEU A  23
 None
 1.07A 1rjdB-3pfeA:
undetectable		 1rjdB-3pfeA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		5 / 12 ILE A  29
ASP A  98
ALA A 160
GLY A 131
LEU A  23
 None
 1.07A 1rjdC-3pfeA:
undetectable		 1rjdC-3pfeA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		4 / 6 ALA A 128
GLU A 446
TYR A  26
ILE A  27
 None
 0.98A 1xvaA-3pfeA:
undetectable
1xvaB-3pfeA:
undetectable		 1xvaA-3pfeA:
20.13
1xvaB-3pfeA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		6 / 12 GLY A 126
GLY A 127
VAL A 434
LEU A  23
LEU A 448
HIS A  96
 None
None
None
None
None
ZN  A 501 (-3.3A)
 1.17A 1ya4C-3pfeA:
2.2		 1ya4C-3pfeA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		3 / 3 ASN A  51
ILE A 158
MET A  81
 None
 0.72A 2h42C-3pfeA:
undetectable		 2h42C-3pfeA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_1
(PROTEASE)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		5 / 11 LEU A 255
GLY A 211
ILE A 372
ALA A 357
ILE A 245
 None
 1.06A 2idwA-3pfeA:
undetectable		 2idwA-3pfeA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA503_0
(CHORISMATE SYNTHASE)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		4 / 5 GLN A  14
THR A 139
ARG A 142
ALA A 143
 None
 1.40A 2qhfA-3pfeA:
undetectable		 2qhfA-3pfeA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		4 / 7 ILE A 372
MET A 339
LEU A 311
LEU A 358
 None
 0.97A 2qqcB-3pfeA:
undetectable
2qqcC-3pfeA:
undetectable		 2qqcB-3pfeA:
11.86
2qqcC-3pfeA:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		4 / 7 LEU A 311
LEU A 358
ILE A 372
MET A 339
 None
 1.00A 2qqcA-3pfeA:
undetectable
2qqcF-3pfeA:
undetectable		 2qqcA-3pfeA:
7.25
2qqcF-3pfeA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		4 / 7 LEU A 311
LEU A 358
ILE A 372
MET A 339
 None
 1.04A 2qqcG-3pfeA:
undetectable
2qqcJ-3pfeA:
undetectable		 2qqcG-3pfeA:
7.25
2qqcJ-3pfeA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		4 / 7 LEU A 311
LEU A 358
ILE A 372
MET A 339
 None
 1.00A 2qqcI-3pfeA:
undetectable
2qqcL-3pfeA:
undetectable		 2qqcI-3pfeA:
7.25
2qqcL-3pfeA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		4 / 7 LEU A 311
LEU A 358
ILE A 372
MET A 339
 None
 1.03A 2qqdA-3pfeA:
undetectable
2qqdE-3pfeA:
undetectable		 2qqdA-3pfeA:
8.59
2qqdE-3pfeA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		4 / 8 ILE A 158
VAL A  50
TYR A 135
CYH A  57
 None
 1.16A 2xz5A-3pfeA:
undetectable
2xz5C-3pfeA:
undetectable		 2xz5A-3pfeA:
18.22
2xz5C-3pfeA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		4 / 8 ILE A 158
VAL A  50
TYR A 135
CYH A  57
 None
 1.13A 2xz5C-3pfeA:
undetectable
2xz5D-3pfeA:
undetectable		 2xz5C-3pfeA:
18.22
2xz5D-3pfeA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		4 / 7 ILE A 158
VAL A  50
TYR A 135
CYH A  57
 None
 1.14A 2xz5D-3pfeA:
undetectable
2xz5E-3pfeA:
undetectable		 2xz5D-3pfeA:
18.22
2xz5E-3pfeA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		5 / 9 ILE A 431
LEU A 189
SER A 133
GLU A 162
CYH A 188
 None
None
None
ZN  A 501 (-3.9A)
None
 1.12A 3ai9X-3pfeA:
undetectable		 3ai9X-3pfeA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		5 / 12 ILE A 141
ALA A 143
GLN A  14
VAL A  91
ILE A 187
 None
 1.01A 3e00A-3pfeA:
undetectable		 3e00A-3pfeA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		5 / 10 ILE A 141
ALA A 143
GLN A  14
VAL A  91
ILE A 187
 None
 1.01A 3falA-3pfeA:
undetectable		 3falA-3pfeA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		5 / 12 TYR A 196
ILE A  53
GLY A 127
ALA A 128
LEU A 189
 GOL  A 522 ( 4.8A)
None
None
None
None
 0.96A 3hs6B-3pfeA:
undetectable		 3hs6B-3pfeA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		3 / 3 SER A 164
ASP A  98
ASN A  31
 GOL  A 523 (-4.2A)
None
None
 1.02A 3lsfB-3pfeA:
undetectable
3lsfE-3pfeA:
undetectable		 3lsfB-3pfeA:
20.77
3lsfE-3pfeA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		5 / 11 TRP A  56
LEU A 189
VAL A 460
LEU A 464
VAL A  91
 None
 1.16A 3w67A-3pfeA:
0.3		 3w67A-3pfeA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_A_QMRA1214_1
(CAPITELLA TELETA
ACHBP)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		5 / 9 VAL A  50
TYR A 135
CYH A  57
ILE A  69
ILE A 158
 None
None
None
GOL  A 517 (-4.2A)
None
 1.21A 4afgA-3pfeA:
0.0
4afgB-3pfeA:
0.0		 4afgA-3pfeA:
17.99
4afgB-3pfeA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		5 / 8 VAL A  50
TYR A 135
CYH A  57
ILE A  69
ILE A 158
 None
None
None
GOL  A 517 (-4.2A)
None
 1.12A 4afgD-3pfeA:
undetectable
4afgE-3pfeA:
undetectable		 4afgD-3pfeA:
17.99
4afgE-3pfeA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		5 / 9 THR A 333
LEU A 337
LEU A 335
VAL A 368
VAL A 215
 None
 1.45A 4c9kB-3pfeA:
undetectable		 4c9kB-3pfeA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		5 / 11 VAL A 434
LEU A 435
ALA A 128
HIS A 449
VAL A 453
 None
IMD  A 513 ( 4.0A)
None
GOL  A 522 (-4.4A)
None
 1.18A 4e0fA-3pfeA:
undetectable		 4e0fA-3pfeA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		5 / 12 TYR A 196
ILE A  53
GLY A 127
ALA A 128
LEU A 189
 GOL  A 522 ( 4.8A)
None
None
None
None
 1.05A 4e1gB-3pfeA:
undetectable		 4e1gB-3pfeA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		5 / 12 LEU A 337
VAL A 313
PHE A 319
PHE A 235
THR A 333
 None
 1.38A 4iaqA-3pfeA:
undetectable		 4iaqA-3pfeA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		5 / 12 LEU A 337
VAL A 313
PHE A 319
PHE A 235
THR A 333
 None
 1.35A 4iarA-3pfeA:
undetectable		 4iarA-3pfeA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		7 / 11 HIS A  96
ASP A 129
GLU A 162
GLU A 163
GLY A 411
GLY A 412
HIS A 442
 ZN  A 501 (-3.3A)
ZN  A 502 ( 2.3A)
ZN  A 501 (-3.9A)
ZN  A 502 (-2.0A)
CL  A 505 (-3.8A)
GOL  A 518 (-3.3A)
ZN  A 502 (-3.2A)
 0.52A 4pqaA-3pfeA:
30.1		 4pqaA-3pfeA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		3 / 3 ASP A 129
HIS A  96
LYS A  99
 ZN  A 502 ( 2.3A)
ZN  A 501 (-3.3A)
None
 0.99A 4qzuD-3pfeA:
undetectable		 4qzuD-3pfeA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		5 / 12 ALA A  49
GLU A 446
ALA A 128
GLY A 131
TYR A  26
 None
 1.21A 4r29B-3pfeA:
undetectable		 4r29B-3pfeA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		5 / 12 LEU A 258
PHE A 370
LEU A 358
GLY A 211
LEU A 311
 None
 1.13A 4zbrA-3pfeA:
undetectable		 4zbrA-3pfeA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		4 / 6 ASP A  98
TYR A 132
TYR A  26
LEU A  23
 None
 1.21A 5bmvB-3pfeA:
3.8		 5bmvB-3pfeA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		4 / 8 LEU A 448
LEU A 456
THR A 139
GLN A  13
 None
 1.05A 5hbsA-3pfeA:
undetectable		 5hbsA-3pfeA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		4 / 6 VAL A 463
LEU A 389
CYH A 459
LEU A 199
 None
 1.16A 5hrqB-3pfeA:
undetectable
5hrqI-3pfeA:
undetectable
5hrqJ-3pfeA:
undetectable		 5hrqB-3pfeA:
4.47
5hrqI-3pfeA:
4.97
5hrqJ-3pfeA:
4.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		5 / 12 GLY A 194
ASP A 451
HIS A 449
ALA A 128
SER A 458
 None
None
GOL  A 522 (-4.4A)
None
None
 1.17A 5igvA-3pfeA:
undetectable		 5igvA-3pfeA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		5 / 12 ILE A 431
LEU A 420
GLU A 162
GLY A 131
TYR A 132
 None
None
ZN  A 501 (-3.9A)
None
None
 1.04A 5uxdB-3pfeA:
undetectable		 5uxdB-3pfeA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		6 / 12 LEU A 448
GLY A 131
GLU A 162
SER A 439
GLY A 126
GLY A 127
 None
None
ZN  A 501 (-3.9A)
IMD  A 513 ( 4.6A)
None
None
 1.26A 5zhmB-3pfeA:
undetectable		 5zhmB-3pfeA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		5 / 12 ASP A 190
ASP A 168
LEU A 176
GLN A 423
LEU A  92
 ZN  A 501 ( 1.9A)
None
None
GOL  A 519 (-4.7A)
None
 1.24A 6ew0F-3pfeA:
undetectable		 6ew0F-3pfeA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		 3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Legionella
pneumophila) 		5 / 11 TYR A 401
ASN A 195
THR A 432
GLY A 433
GLU A 410
 None
None
None
None
ZN  A 504 ( 2.1A)
 1.41A 6mb5A-3pfeA:
undetectable		 6mb5A-3pfeA:
10.32