SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pfi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 3pfi HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVB
(Campylobacter
jejuni) 		4 / 4 GLY A 278
LEU A 279
GLY A 313
ARG A 314
 None
 0.70A 1j7kA-3pfiA:
12.6		 1j7kA-3pfiA:
46.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 3pfi HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVB
(Campylobacter
jejuni) 		5 / 12 LEU A 248
ASN A 249
LEU A 251
GLY A 252
ARG A 222
 None
 0.95A 1p93A-3pfiA:
undetectable		 1p93A-3pfiA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 3pfi HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVB
(Campylobacter
jejuni) 		5 / 12 ALA A 157
LEU A 178
LEU A  38
ILE A  55
THR A 158
 None
 1.17A 1re7B-3pfiA:
undetectable		 1re7B-3pfiA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9A_A_BEZA306_0
(CHLOROCATECHOL
1,2-DIOXYGENASE)		 3pfi HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVB
(Campylobacter
jejuni) 		5 / 11 ASP A 105
ILE A 106
TYR A 130
HIS A  54
CYH A  51
 None
 1.29A 1s9aA-3pfiA:
undetectable		 1s9aA-3pfiA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9A_B_BEZB307_0
(CHLOROCATECHOL
1,2-DIOXYGENASE)		 3pfi HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVB
(Campylobacter
jejuni) 		5 / 12 ASP A 105
ILE A 106
TYR A 130
HIS A  54
CYH A  51
 None
 1.29A 1s9aB-3pfiA:
undetectable		 1s9aB-3pfiA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3pfi HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVB
(Campylobacter
jejuni) 		3 / 3 LYS A  65
ASP A 295
ASP A 289
 ADP  A 336 (-2.7A)
None
None
 1.02A 2br4A-3pfiA:
undetectable		 2br4A-3pfiA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 3pfi HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVB
(Campylobacter
jejuni) 		3 / 3 ASP A 295
THR A 216
PRO A 217
 None
None
ADP  A 336 (-4.3A)
 0.55A 2pynB-3pfiA:
undetectable		 2pynB-3pfiA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 3pfi HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVB
(Campylobacter
jejuni) 		5 / 12 LEU A 248
ASN A 249
LEU A 251
GLY A 252
ARG A 222
 None
 0.98A 2q7lA-3pfiA:
undetectable		 2q7lA-3pfiA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 3pfi HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVB
(Campylobacter
jejuni) 		3 / 3 ASP A 295
THR A 216
PRO A 217
 None
None
ADP  A 336 (-4.3A)
 0.57A 2qakB-3pfiA:
undetectable		 2qakB-3pfiA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3pfi HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVB
(Campylobacter
jejuni) 		5 / 11 ILE A 155
ILE A  72
ILE A  34
PHE A  57
THR A 153
 None
 1.02A 2w9sA-3pfiA:
undetectable		 2w9sA-3pfiA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3pfi HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVB
(Campylobacter
jejuni) 		5 / 11 ILE A 155
ILE A  72
ILE A  34
PHE A  57
THR A 153
 None
 1.02A 2w9sB-3pfiA:
undetectable		 2w9sB-3pfiA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3pfi HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVB
(Campylobacter
jejuni) 		5 / 10 ILE A 155
ILE A  72
ILE A  34
PHE A  57
THR A 153
 None
 1.05A 2w9sC-3pfiA:
undetectable		 2w9sC-3pfiA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 3pfi HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVB
(Campylobacter
jejuni) 		5 / 12 LEU A  98
ASP A  93
THR A  83
ILE A 109
LEU A 115
 None
 1.18A 4o5fA-3pfiA:
undetectable
4o5fB-3pfiA:
undetectable		 4o5fA-3pfiA:
22.29
4o5fB-3pfiA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 3pfi HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVB
(Campylobacter
jejuni) 		5 / 12 LEU A 115
LEU A  98
ASP A  93
THR A  83
ILE A 109
 None
 1.18A 4o5fA-3pfiA:
undetectable
4o5fB-3pfiA:
undetectable		 4o5fA-3pfiA:
22.29
4o5fB-3pfiA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 3pfi HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVB
(Campylobacter
jejuni) 		3 / 3 PRO A 125
MET A 127
TYR A 124
 None
 1.01A 4qa2B-3pfiA:
undetectable		 4qa2B-3pfiA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 3pfi HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVB
(Campylobacter
jejuni) 		5 / 12 LEU A  98
ASP A  93
THR A  83
ILE A 109
LEU A 115
 None
 1.21A 5b8hA-3pfiA:
undetectable
5b8hB-3pfiA:
undetectable		 5b8hA-3pfiA:
22.90
5b8hB-3pfiA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 3pfi HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVB
(Campylobacter
jejuni) 		5 / 12 LEU A 115
LEU A  98
ASP A  93
THR A  83
ILE A 109
 None
 1.17A 5b8hA-3pfiA:
undetectable
5b8hB-3pfiA:
undetectable		 5b8hA-3pfiA:
22.90
5b8hB-3pfiA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 3pfi HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVB
(Campylobacter
jejuni) 		5 / 9 LEU A 115
LEU A  94
LEU A 164
PRO A 125
ALA A 126
 None
 1.08A 5og9A-3pfiA:
undetectable		 5og9A-3pfiA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 3pfi HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVB
(Campylobacter
jejuni) 		5 / 12 LEU A 248
ASN A 249
LEU A 251
GLY A 252
ARG A 222
 None
 1.01A 5uc1B-3pfiA:
undetectable		 5uc1B-3pfiA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3pfi HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVB
(Campylobacter
jejuni) 		3 / 3 MET A 163
ASP A 289
ARG A 314
 None
 1.13A 5z6kA-3pfiA:
undetectable		 5z6kA-3pfiA:
18.26