SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pfr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Actinobacillus
succinogenes) 		5 / 10 TYR A 154
PHE A 212
VAL A 446
PRO A 237
GLY A 214
 None
 1.34A 13gsA-3pfrA:
undetectable		 13gsA-3pfrA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Actinobacillus
succinogenes) 		4 / 8 LEU A 192
SER A 196
GLY A 201
TRP A 175
 None
 0.78A 1fapB-3pfrA:
undetectable		 1fapB-3pfrA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Actinobacillus
succinogenes) 		5 / 12 GLY A 210
GLY A 209
VAL A 221
LEU A 235
LEU A 207
 None
 1.07A 1mx1F-3pfrA:
undetectable		 1mx1F-3pfrA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Actinobacillus
succinogenes) 		5 / 12 LEU A 257
LEU A 224
ALA A 194
ALA A 193
VAL A 221
 None
 1.14A 1rbpA-3pfrA:
undetectable		 1rbpA-3pfrA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Actinobacillus
succinogenes) 		4 / 5 LEU A 235
LEU A 207
LEU A  26
MET A 184
 None
 1.12A 2oaxF-3pfrA:
undetectable		 2oaxF-3pfrA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Actinobacillus
succinogenes) 		5 / 12 ALA A 313
ASP A 314
ALA A 327
HIS A 354
LEU A 320
 None
 0.81A 2yqzA-3pfrA:
undetectable		 2yqzA-3pfrA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Actinobacillus
succinogenes) 		5 / 12 ALA A 313
ASP A 314
ALA A 327
HIS A 354
LEU A 320
 None
 0.82A 2yqzB-3pfrA:
undetectable		 2yqzB-3pfrA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Actinobacillus
succinogenes) 		4 / 6 VAL A  42
LEU A 349
ILE A  11
ILE A  43
 None
 0.94A 3gcsA-3pfrA:
undetectable		 3gcsA-3pfrA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Actinobacillus
succinogenes) 		6 / 11 VAL A 326
ILE A 310
ALA A 313
ALA A 293
ALA A 288
THR A 289
 None
 1.25A 3mdtB-3pfrA:
undetectable		 3mdtB-3pfrA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Actinobacillus
succinogenes) 		4 / 6 ALA A 113
ILE A  62
VAL A  16
ASN A  40
 None
 1.10A 3nneG-3pfrA:
undetectable		 3nneG-3pfrA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Actinobacillus
succinogenes) 		4 / 8 ASN A 290
HIS A 369
ASP A 367
GLU A 217
 MG  A 456 ( 2.6A)
GKR  A 457 (-3.8A)
None
None
 1.05A 3sg9B-3pfrA:
undetectable		 3sg9B-3pfrA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Actinobacillus
succinogenes) 		5 / 12 LEU A 257
ASN A 254
LYS A 251
ALA A 246
ILE A 218
 None
 1.19A 3ut5D-3pfrA:
undetectable		 3ut5D-3pfrA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		 3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Actinobacillus
succinogenes) 		3 / 3 ARG A 179
ARG A 199
TRP A 175
 None
 1.39A 4b7nA-3pfrA:
undetectable		 4b7nA-3pfrA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Actinobacillus
succinogenes) 		3 / 3 ARG A 179
ARG A 199
TRP A 175
 None
 1.38A 4cpzC-3pfrA:
undetectable		 4cpzC-3pfrA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Actinobacillus
succinogenes) 		3 / 3 ARG A 179
ARG A 199
TRP A 175
 None
 1.35A 4cpzE-3pfrA:
undetectable		 4cpzE-3pfrA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		 3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Actinobacillus
succinogenes) 		3 / 3 ARG A 179
ARG A 199
TRP A 175
 None
 1.32A 4cpzF-3pfrA:
undetectable		 4cpzF-3pfrA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		 3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Actinobacillus
succinogenes) 		3 / 3 ARG A 179
ARG A 199
TRP A 175
 None
 1.32A 4cpzG-3pfrA:
undetectable		 4cpzG-3pfrA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		 3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Actinobacillus
succinogenes) 		3 / 3 ARG A 179
ARG A 199
TRP A 175
 None
 1.39A 4cpzH-3pfrA:
undetectable		 4cpzH-3pfrA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_1
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Actinobacillus
succinogenes) 		4 / 4 THR A 321
GLU A 118
ARG A 325
HIS A  89
 None
 1.01A 4hvcA-3pfrA:
undetectable		 4hvcA-3pfrA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_1
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Actinobacillus
succinogenes) 		4 / 5 THR A 321
GLU A 118
ARG A 325
HIS A  89
 None
 1.04A 4hvcB-3pfrA:
undetectable		 4hvcB-3pfrA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Actinobacillus
succinogenes) 		3 / 3 ASP A 123
LEU A  81
VAL A  74
 None
 0.70A 4jecB-3pfrA:
undetectable		 4jecB-3pfrA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Actinobacillus
succinogenes) 		6 / 12 ALA A 350
GLY A 398
GLY A 400
LEU A 129
ILE A  78
LEU A  81
 None
 1.10A 4n49A-3pfrA:
undetectable		 4n49A-3pfrA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Actinobacillus
succinogenes) 		4 / 6 LEU A 207
LEU A 192
VAL A 189
PHE A 153
 None
None
None
GKR  A 457 (-4.7A)
 1.12A 4uswA-3pfrA:
undetectable		 4uswA-3pfrA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Actinobacillus
succinogenes) 		5 / 12 GLY A 209
LEU A 207
ASP A 219
VAL A 189
VAL A 256
 None
 1.19A 4wnwA-3pfrA:
undetectable		 4wnwA-3pfrA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Actinobacillus
succinogenes) 		4 / 6 SER A 242
LEU A 243
ASP A 244
TYR A 270
 None
 0.98A 4wozA-3pfrA:
7.5
4wozB-3pfrA:
11.9		 4wozA-3pfrA:
19.56
4wozB-3pfrA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Actinobacillus
succinogenes) 		4 / 6 LEU A 384
ASN A 382
PRO A 383
ARG A  39
 None
 1.26A 4yv5B-3pfrA:
undetectable		 4yv5B-3pfrA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Actinobacillus
succinogenes) 		4 / 6 LEU A 384
ASN A 382
PRO A 383
ARG A  39
 None
 1.28A 4yv5A-3pfrA:
undetectable		 4yv5A-3pfrA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)		 3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Actinobacillus
succinogenes) 		3 / 3 TRP A 241
GLU A 217
ASP A 236
 None
None
MG  A 456 ( 2.7A)
 0.47A 5gqbA-3pfrA:
5.5		 5gqbA-3pfrA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Actinobacillus
succinogenes) 		5 / 12 ILE A 218
LEU A 249
PRO A 237
VAL A 221
GLY A 209
 None
 1.11A 5nnaC-3pfrA:
undetectable		 5nnaC-3pfrA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Actinobacillus
succinogenes) 		5 / 9 LEU A 349
ALA A 350
PHE A 352
VAL A 148
ILE A 386
 None
 1.12A 5om2A-3pfrA:
undetectable
5om2B-3pfrA:
undetectable		 5om2A-3pfrA:
10.33
5om2B-3pfrA:
6.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Actinobacillus
succinogenes) 		4 / 5 HIS A  33
ASP A 236
GLY A 209
ASN A  28
 GKR  A 457 (-3.8A)
MG  A 456 ( 2.7A)
None
GKR  A 457 (-3.4A)
 1.15A 5x7pB-3pfrA:
undetectable		 5x7pB-3pfrA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Actinobacillus
succinogenes) 		5 / 12 ALA A 358
ALA A 359
GLN A 328
LEU A 137
LEU A 366
 None
 0.99A 5z12C-3pfrA:
undetectable		 5z12C-3pfrA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_1
(UNCHARACTERIZED
PROTEIN)		 3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Actinobacillus
succinogenes) 		4 / 4 THR A 321
GLU A 118
ARG A 325
HIS A  89
 None
 1.14A 6mn8A-3pfrA:
0.0		 6mn8A-3pfrA:
21.04